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All rights reserved."],["topImageUrl",null],["error",null]]}]}],["text","https://payment.ecpay.com.tw/Cashier/AioCheckOut/V5"],["replyRequests",{"__iterable":"List","data":[{"__iterable":"Map","data":[["id","xd87bsqbxhb1__j4S8C_c0HakM7S3ZY8cZfBUA9UYhPJc40n0ZEXpXCF_98Rlu8__RUMORS_LINE_BOT"],["reason",""],["positiveFeedbackCount",0],["negativeFeedbackCount",0]]}]}],["id","xd87bsqbxhb1"],["createdAt","2024-07-31T22:28:56.043Z"]]}],["replyConnections",{"__iterable":"List","data":[]}],["relatedArticles",{"__iterable":"List","data":[{"__iterable":"Map","data":[["replyCount",4],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_xKGo3g-HTVqTBBpOjChzkhT4lx_Fry5Dd_aZvLNrEUk"],["name","可靠的楠西桃樂斯"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","ACE王牌數位貨幣交易"],["url","https://www.ace.io/activity/invite-register?invite_code=00025776"],["summary","Copyright © 2018-2019 Ace Digital Innovations Co., Ltd. 王牌數位創新股份有限公司 All Rights Reserved."],["topImageUrl","https://www.ace.io/dda5fd010bfa0160e8edbd6dc90212e6.png"],["error",null]]}]}],["text","台灣唯一完全合法落地交易所，更榮獲經濟部核准補助，嚴守KYC.AML規格，ABA x ACE x ABF=ABE虛擬貨幣實體交易所，打造台灣最大最完整區塊鏈技術，並提供法規.財稅.技術.產品.業務.行銷全方面輔導。\n\n現在註冊ACE完成實名B級認證\n就送超多獎勵回饋金！\n\n盡快把握時間參與活動，並且將此消息分享給親朋好友吧！\n\n註冊邀請碼\nhttps://www.ace.io/activity/invite-register?invite_code=00025776\n心存善念，絕不詐騙"],["id","2y4yg1kklj78c"],["createdAt","2019-12-07T03:10:06.555Z"]]},{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",3],["user",{"__iterable":"Map","data":[["id","j4S8C_KBTd9Mn5Jo1sbkIl-yNV90jK1iaYnhabtSK15zNCJ6w"],["name","激勵性的五峰瑪麗"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","桃園振興觀光義勇軍"],["url","http://tourcash.tycg.gov.tw/"],["summary","桃園振興觀光義勇軍\n \n \n \n 活動介紹\n 立即申領消費者中獎專區 \n 業者專區\n 可兌換店家\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n coming soon ...\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n 謝謝你好朋友股份有限公司 | LINE@ ID:@3qmf-tycg | 客服時間：週一至週五 09:00~18:00\nCopyright ©2020 by Thankyoumyfriends Co., Ltd. All Rights reserved."],["topImageUrl",null],["error",null]]}]}],["text","限桃園市民\nhttp://tourcash.tycg.gov.tw/ 記得6/22(一)上午九時，去登錄。"],["id","249dbbggfj44r"],["createdAt","2020-06-21T13:39:54.183Z"]]},{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",2],["user",{"__iterable":"Map","data":[["id","j4S8C_ITHM5Z0AewWmcMUHMt9bmYIGkqR4Ym9bwRzCN-nYE5E"],["name","貫徹始終的桃源史丹佛"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","加入meellove - 在這裏結識朋友"],["url","https://meellove.com/index.html#/m/home/trend/list"],["summary","關於我們 | 服務條款 | 隱私政策 | 退款協議 | 幫助中心 | 聯係我們 Copyright ©2024 HONGKONG JIHONGYUN TRADE DEVELOPMENT CO., LIMITED(UNIT D 16/F ONE CAPITAL PLACE 18 LUARD ROAD WAN CHAI HK) All Rights Reserved."],["topImageUrl",null],["error",null]]}]}],["text","https://meellove.com/index.html#/m/home/trend/list"],["id","4hmw8tjmsw6a"],["createdAt","2024-04-04T11:39:09.659Z"]]},{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_mI3eOi52-Ww8Qq5y5k_tJ3CWNHrGzRuHzrVl8C-IC94"],["name","老練的新莊傑森"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","早安健康｜抗氧化物質比綠茶多137倍！抗疲勞7大強食"],["url","https://bit.ly/2EEIf1w"],["summary","【早安健康／曾大容報導】在市場、超市採買時，選擇越多越茫然，如何在有限的預算下，買到最多對健康有益處的食材呢？謹記以下由國外多個知名營養師提出的七個最強食材，讓你的餐桌成為消解全家人疲勞的最強補給站吧！\n抹茶，多酚是綠茶的137倍！\n美國知名營養師弗朗西絲·拉吉曼-羅斯認為，抹茶即將作為一種營養豐富的食品，在歐美地區大流行！將茶葉乾燥之後再研磨成粉的抹茶，這樣的特殊製法讓它的抗氧化物質－多酚，比綠茶還要多137倍！\n\n而且咖啡因是一般咖啡的一半，特別推薦給在下午容易感到疲勞、想睡，但攝取過多的咖啡因晚上又會睡不著的人。不過要注意到的是，小心別攝取過多糖分，盡量選擇無糖或減糖的粉末來飲用。\n香蕉\n英國暢銷書作家、同時也是營養師的瑪莉蓮格連威利的醫師認為，接近傍晚或天氣陰暗時，容易情緒低落、感到疲勞，但自己可能沒有發覺，所以適時的補充血清素、也就是提升「快樂荷爾蒙」來說　再搭配糙米全麥燕麥等未精緻過的碳水化合物一起食用的話，可以促進胰島素的分泌、幫助色胺酸的傳達，為體內製造出更好的血清素。\n藍莓\n藍莓含有大量的花色素苷，也含有比其他的水果更豐富的抗氧化物質，英國營養學專家蓋塔羅布認為，抗氧化物質能夠修復自由基等有害物質對人體造成的不好影響、舒緩眼睛疲勞、守護泌尿器官的健康、維持強健的體力。\n青甜椒\n蓋塔羅布認為，維生素C可以強化免疫力、減輕疲勞，一般我們可能認為柑橘類維生素C含量高，但青甜椒的維生素C是柑橘類的3倍！尤其紅色的甜椒含有更多的β-胡蘿蔔素、植化素，具有的抗氧化和抗發炎的效用更強。\n\n\n更多能夠消除疲勞的好食物，下一頁與您分享！"],["topImageUrl","https://c1.staticflickr.com/1/883/26258353237_9d1b855bdc_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康｜腸道水腫讓你便祕、腰圍粗！這樣做腰瘦5公分"],["url","http://bit.ly/29suxCa"],["summary","【早安健康／周舒涵編譯】您是否老是覺得肚子脹脹的，又有惱人的便祕症狀呢？快跟著下面的自我檢查表，來看看自己是不是屬於腸道水腫的患者，以及就算因為腸道水腫導致便祕的話也不用太過擔心，日本腸道名醫小林弘幸指出，「每消除腸道水腫5毫米，腰圍就可減5公分！」跟著吃他所推薦的蜂蜜蘿蔔泥優格，再加上簡單的解便祕按摩體操，就可以輕鬆解決您的便祕煩惱。\n\n \n腸道水腫造成的便祕，導致身體發胖腸道水腫是因為大腸環境惡化，吸收了多餘的水分造成水腫所導致的發炎反應，只要有長時間便祕的現象，罹患腸道水腫的可能性就會提高。罹患腸道水腫的話，大腸的蠕動會惡化，吸收能力也會下降，吃下去的食物可能會堆積成為皮下脂肪或內臟脂肪，導致身材肥胖。如果想要瘦下來的話，改善便祕症狀是最重要的第一件事。\n\n \n跟著以下五點，確認自己有沒有腸道水腫的症狀！ \n ○一個月中有數次3天以上沒有排便的狀態。 \n ○使用5年以上的助排泄藥物。 \n ○肚子感覺起來硬硬的很結實。 \n ○常常會有脹脹的感覺。 \n ○雖然會定期排便但每次都會有排不乾淨的感覺。 \n \n 以上5點，只要有符合超過1項，就必須要注意可能患有腸道水腫的症狀。如果發現自己有腸道水腫或者便秘症狀的話，快跟著小林弘幸醫師的建議，從飲食與按摩體操著手，雙管齊下消除惱人的排毒問題。\n\n \n吃蜂蜜蘿蔔泥優格，有效改善症狀小林弘幸醫師推薦，如果有腸道水腫與便祕症狀，可以食用蜂蜜蘿蔔泥優格改善，其中蜂蜜所含的寡糖可以促進腸道中比菲德氏菌的增加。另外攝取大豆、薯類或穀類，會增加糞便體積的非水溶性膳食纖維相比，若想排除腸道囤積已久的廢物，搭配白蘿蔔中可以使糞便軟化的水溶性膳食纖維較為適合。\n\n \n每天10分鐘超簡單按摩體操，告別腸道水腫與便祕 \n步驟１雙腳張開與肩同寬站立。 \n \n ２右手緊緊捏住位於右側的恥骨上方腰部。\n \n \n ３左手捏住位於左側的肋骨下方腰部。\n\n \n \n ４順時針慢慢的大幅轉腰5圈，可以的話最好搭配兩隻手的搓揉。 \n \n ５再逆時針慢慢的大幅轉腰5圈。（換方向轉動的時候兩隻手抓住的位置不用改變） \n \n ６一天進行5～10次，時間總計大約10分鐘。 \n \n \n \n 【延伸閱讀】\n\n一日瘦身飲食表，點心3點吃不發胖、睡前吃優格清腸消便秘！\n\n保溫杯煮黑豆茶！3帖減肥茶消水腫、不便秘\n\n早上3分鐘排毒操！喚醒腸道，如廁好順暢"],["topImageUrl","https://farm6.staticflickr.com/5617/20334358055_8c0d8ba091_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康嚴選"],["url","https://shop.everydayhealth.com.tw/l.php?1c8exz&openExternalBrowser=1"],["summary","【九月慶中秋】親友相聚送禮表心意，滿額再加贈超值好禮\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\t\t●●●●●●●●●●●●●●●●\t\t\t\t\t\n\n\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\n\t\t\n\n\n\n\n\n個資安全加密\nSSL憑證安全付款 \n\n\n\n \n\n購物滿1200元\n整筆訂單免運費 \n\n\n\n \n\n加入LINE好友\n立即現折100元 \n\n\n\n \n\n立即來電訂購 \n02-5596-7262\n\t\n\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\n\t\t\t\t\n\t\t\n\n\t\t\t\n\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tAmericanTraveler 20吋超輕量抗刮行李箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\n\t\n\t\t\n\t夏養三伏，冬補三九\n\t\n\t\t\n\t\t\n\t\t\t一年之中最熱的三伏即將到來\n是中醫預防醫學中「冬病夏治」的好時機\n分別是夏至後的第三個庚日「初伏」\n第四個庚日「中伏」、立秋後第一個庚日「末伏」\t\t\n\t\n\t\n\t\t\t\n\n\t\t\t\n\n\t\t\t「夏季要一天洗幾次頭才夠呢？頭髮多只要一流汗頭皮癢，洗完還是悶悶的！」\n「每天都要戴著安全帽騎車通...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t一年四季都適合端上桌的快手料理。備料迅速、不會花太多時間，滋味香醇潤口，忙碌的時候也能好好上菜，可說...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t8more老客人梓瑩Janet：「隨著人生一路轉折，我認識到生命就是能量的流動，心胸越開放不執著，就...\n\t\t\n\t\t\t\n\n\t\n\t\n\t\n\t\n\n\t\n\n\n\n\n\n\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t客服專線 02-5596-7262 ｜服務時間週一至週五 9:30-12:30/13:30-18:00\n\n\t\t\t©2018 早安健康股份有限公司版權所有，轉載必究 Copyright Everyday Health Co,Ltd All Rights Reserved"],["topImageUrl","https://ftp.pic.everydayhealth.com.tw/edh_upload/website_info/pic_logo_1.png?1475814226"],["error",null]]}]}],["text","(cocktail)贏綠茶137倍這杯最抗疲勞\nhttps://bit.ly/2EEIf1w\n\n(drop)【便祕、腰圍粗】這樣做消腸道水腫，還能腰瘦5公分\nhttp://bit.ly/29suxCa\n\n(no)拒絕脂溶性農藥下肚！天然食材萃取的蔬果清潔劑，友善環境安心推薦2件9折\nhttps://shop.everydayhealth.com.tw/l.php?1c8exz&openExternalBrowser=1"],["id","ymcxsh2sw50j"],["createdAt","2018-04-12T04:47:31.785Z"]]},{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_iwVjDjINyiDpn7RbTFqTWf6CzdOxSJbasBOvvyiFAaM"],["name","令人信服的竹北南茜"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","早安健康｜致死率比癌症高！預防更年期骨質疏鬆飲食對策"],["url","https://bit.ly/2rYuN4b"],["summary","【早安健康／余雅雯（中醫師）】\n更年期的骨質疏鬆問題\n\n更年期還有一個需要特別注意的問題就是骨質疏鬆，上了年紀的人，因髖關節骨折而致死的機率甚至比癌症還高。\n\n女性過了三十五歲，骨本會隨著年齡慢慢的減少，所以鼓勵女性在三十五歲前一定要存夠骨本。骨質疏鬆一開始是不會有感覺的，直到常常感到腰痠背痛，背越來越駝，而且每次量身高都變得越來越矮，才會開始意識到這個問題。骨質疏鬆嚴重的話，有可能打個噴嚏、輕微跌倒，就會造成不小的意外，所以上了年紀的女性一定要特別小心，尤其居家安全措施必須做好。\n\n女性隨著更年期的報到，動情激素減少，會造成骨骼中鈣質的析出，而且降低維生素D的活性。偏偏這個年齡腸胃道吸收並不如年輕，即使吃一樣的食物，對於鈣的吸收也沒有那麼好，導致骨質密度減少，就會越來越疏鬆，造成腰痠背痛等現象。如果用影像學去看骨質疏鬆的骨頭，會發現中空而且疏鬆，就跟海砂屋一樣，其實是骨頭因疏鬆而變薄、變脆弱，並且容易造成骨折。\n中醫治療骨質疏鬆對策\n\n中醫稱骨質疏鬆為「骨萎」，由於腎主骨，因此骨萎除了與腎氣衰竭有關，也與任督二脈衰竭相關。一般人往往有個錯誤的迷思，以為面對骨質疏鬆問題，只要不斷補鈣就好，許多老人家也會吃維骨力來避免骨本流失。事實上如果腎氣沒有調節好，那麼再好的保健食品都吸收不了，所以腎氣一定要充足。\n\n腎為先天之本，補強之後，後天的氣血循環才會好，並且發揮真正的功能。中醫對於骨萎的治療重點就是補腎，藥材上常常會使用補腎的左歸丸、右歸丸、龜鹿二仙膠，補脾胃氣血的八珍湯、六君子湯。保健食品當然可以吃，但同時調節腎氣，才能讓吸收更好。\n\n因此除了葡萄糖胺或維骨力等保健食品外，建議從補充腎氣著手，例如龜鹿二仙膠、杜仲、獨活、肉蓯蓉、熟地、大補精髓，可促進成骨細胞增殖，抑制破骨細胞活性，並且經由腎氣系統的提升，補充全身的骨本。\n骨質疏鬆飲食對策\n\n骨質疏鬆，可以透過X光骨質吸收儀來測量骨質密度，其結果會與正常成人最高密度相比較，若標準差低於二點五即為骨質疏鬆症。\n\n根據衛生福利部食品藥物管理署資料指出，國人鈣質建議攝取量如下：\n\n \n \n 一至三歲\n 五百毫克\n \n \n 四至六歲\n 六百毫克\n \n \n 七至九歲\n 八百毫克\n \n \n 十至十二歲\n 一千毫克\n \n \n 十三至十八歲\n 一千兩百毫克\n \n \n 十九歲以上成人、銀髮族\n 一千毫克\n \n \n\n\n\n35歲前是存骨本黃金期！下一頁中醫師介紹骨質疏鬆預防食療"],["topImageUrl","https://c1.staticflickr.com/1/954/42118070562_e6548e00d7_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康｜水果飯前吃還是飯後吃才對？聽聽專家怎麼說"],["url","http://bit.ly/28IfypE"],["summary","【早安健康／Hero祖雄（FISAF國際體育有氧體適能聯盟認證專業基礎核心訓練師和體適能指導員）】主張飯前吃水果的人，認為方便腸胃吸收，有助於維他命的吸收。而且這樣做還能控制食量，減少正餐攝取精緻澱粉的機會。甚至還有一種危言聳聽的說法是認為，飯後吃水果會讓水果在腸胃中滯留太久，產生發酵、有機酸，引起腹脹、腹瀉等問題。 \n \n而主張飯後吃水果的人，則是認為飯前吃水果容易造成熱量過高，與血糖快速升高的問題。因為刺激胰島素大量分泌，長久下來會導致胰島素產生抗阻性的問題，進一步引起血糖過高與脂肪囤積的疾病。 \n \n以上兩種說法是截然不同的理念，對於一般民眾來說，選擇相信任何一邊都是有可能的！我們先一一來看看箇中原因。 \n \n \n飯前吃水果有助於腸胃吸收嗎？ \n答：會，單獨吃下水果，比起與眾多食物一起吃，更方便吸收利用，也有助於維他命的吸收。但正是因為吸收快，血糖升高得也快，糖分在血液中份量比例越來越高，會提高血液的酸性而開始破壞血管！此時身體會分泌胰島素來快速將糖分帶入細胞中利用，過多的糖分會馬上被轉換成三酸甘油脂，再透過血液帶到全身各處，形成脂肪囤積起來。 \n \n血糖快速升高對於健康絕對沒有任何好處，而健康養生的第一個觀念，就是要盡量控制血糖不讓它快速升高。維持血糖的穩定正是維持健康一輩子的課題，所以單從這一點就能清楚知道，飯前吃水果帶來的壞處了吧？"],["topImageUrl","https://farm8.staticflickr.com/7453/27028229084_4fd7961427_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康嚴選"],["url","https://shop.everydayhealth.com.tw/l.php?1cg50p"],["summary","【九月慶中秋】親友相聚送禮表心意，滿額再加贈超值好禮\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\t\t●●●●●●●●●●●●●●●●\t\t\t\t\t\n\n\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\n\t\t\n\n\n\n\n\n個資安全加密\nSSL憑證安全付款 \n\n\n\n \n\n購物滿1200元\n整筆訂單免運費 \n\n\n\n \n\n加入LINE好友\n立即現折100元 \n\n\n\n \n\n立即來電訂購 \n02-5596-7262\n\t\n\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\n\t\t\t\t\n\t\t\n\n\t\t\t\n\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tAmericanTraveler 20吋超輕量抗刮行李箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\n\t\n\t\t\n\t夏養三伏，冬補三九\n\t\n\t\t\n\t\t\n\t\t\t一年之中最熱的三伏即將到來\n是中醫預防醫學中「冬病夏治」的好時機\n分別是夏至後的第三個庚日「初伏」\n第四個庚日「中伏」、立秋後第一個庚日「末伏」\t\t\n\t\n\t\n\t\t\t\n\n\t\t\t\n\n\t\t\t「秋分」這天，太陽直射達到180度，使晝夜各12小時，此後，北半球晝短夜長，天氣漸漸轉涼，此時是調整...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t8more老客人梓瑩Janet：「隨著人生一路轉折，我認識到生命就是能量的流動，心胸越開放不執著，就...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t走進市場，白木耳與黑木耳除了名字「黑白」不同，外觀看起來非常相似。你分得清楚兩者有什麼差異呢？...\n\t\t\n\t\t\t\n\n\t\n\t\n\t\n\t\n\n\t\n\n\n\n\n\n\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t客服專線 02-5596-7262 ｜服務時間週一至週五 9:30-12:30/13:30-18:00\n\n\t\t\t©2018 早安健康股份有限公司版權所有，轉載必究 Copyright Everyday Health Co,Ltd All Rights Reserved"],["topImageUrl","https://ftp.pic.everydayhealth.com.tw/edh_upload/website_info/pic_logo_1.png?1475814226"],["error",null]]}]}],["text","(exasperated)比癌更致死！女醫吃1盤保命\nhttps://bit.ly/2rYuN4b\n\n(pencil)飯前吃或飯後吃？水果何時吃，聽聽專家怎麼說\nhttp://bit.ly/28IfypE\n\n(ok)吃好油助代謝！第一道冷壓初榨椰子油可烹飪/油漱/護髮/護膚/護唇安心好用！2件再送椰油皂\nhttps://shop.everydayhealth.com.tw/l.php?1cg50p"],["id","nwroasjharnb"],["createdAt","2018-05-21T04:11:55.016Z"]]},{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_iwVjDjINyiDpn7RbTFqTWf6CzdOxSJbasBOvvyiFAaM"],["name","令人信服的竹北南茜"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","早安健康｜黑木耳4大養生功效！超級食材黑木耳助減肥抗癌"],["url","http://bit.ly/2aXlVTW"],["summary","【早安健康／林姿彣整理編輯】黑木耳有「養生萬靈丹」美稱，有鈣質、鐵質、維生素等豐富營養，其實也是超級減肥食材！到底黑木耳的功效有哪些？富含哪些營養帶來養生效果呢？\n黑木耳營養價值\n\n\n 維生素B2\n 鈣質\n 鐵質\n\n「人不可貌相」這句話很適合用在黑木耳上，黑木耳雖然沒有吸引人的外表，但是內在卻富含各種驚人的營養素，像是它的維生素B2含量，是米、麵和大白菜的10倍，鈣含量也是肉類的30～70倍，鐵質更是肉類的100倍之多！\n黑木耳是減肥好食材！\n\n 低熱量\n 富含纖維質\n 容易有飽足感\n 植物性膠質\n黑木耳最大的特色是可以作為減肥的天然食品！因為黑木耳熱量低、富含纖維質，可減少食物攝取量，吃下去容易有飽足感，能達到減重效果；此外，黑木耳是植物性膠質，所以能夠隨著腸胃蠕動，附著在胃壁和腸道上，減緩胃腸酵素分泌到腸胃中，進而降低飢餓感。\n黑木耳富含膳食纖維改善便秘\n\n對於外食族而言，黑木耳有一個很重要的好處，那就是它含有豐富的膳食纖維！根據長庚醫院營養治療科團隊合著的《營養師教你跟著四季吃健康》，每100克黑木耳就含有6.5克的膳食纖維，與我們耳熟能詳高營養價值的蔬菜相比（如高麗菜1.3克、空心菜2.1克、花椰菜2.2克、菠菜2.4克、地瓜葉3.1克），黑木耳顯然是大富翁！因此，多吃黑木耳，非常有益於腸胃蠕動、消解便秘。食材膳食纖維比一比：黑木耳膳食纖維多\n\n \n \n 食材\n 膳食纖維(每100克)\n \n \n 黑木耳\n 6.5克\n \n \n 地瓜葉\n 3.1克\n \n \n 花椰菜\n 2.2克\n \n \n 空心菜\n 2.1克\n \n \n 高麗菜\n 1.3克\n \n \n 菠菜\n 2.4克\n \n \n\n養生食材：黑木耳，鐵鈣雙全，清血管清腸道！\n\n \n\n\n研究：黑木耳入中藥改善肥胖\n事實上，黑木耳的減重效果，蠻早就被發現。長期研究黑木耳的南台科大生技所教授陳啟楨，在2005年的實驗中，發現將黑木耳加入中藥裡，可以有效改善肥胖者的神經、內分泌、消化等系統，進而降低肥胖者食慾，達到減重效果。所以，趕快多吃一點黑木耳吧！ \n黑木耳養顏美容\n \n要是因為木耳黑黑的，就認為它不具有養顏美容的效果的話，那你可就大錯特錯了！在2009年時就已經有研究顯示，如果連續4週，塗抹含0.5％的黑木耳萃取物乳霜，能夠有效提高皮膚含水率，而且相較於未使用者，有使用的人皮膚較白，這表示黑木耳可以降低黑色素沉澱。 \n \n【延伸閱讀】\n\n 黑木耳好處多！料理達人教你用電鍋自製黑木耳露\n 不花大錢買補品！抗癌美食家教你用木耳養生\n 補充膠原蛋白！電鍋就能做出水果白木耳甜湯\n 在家自製天然補品！用電鍋就能煮出超營養黑木耳露\n 4大黃金排毒食材！黑木耳富含纖維、地瓜葉促糖代謝"],["topImageUrl","https://farm9.staticflickr.com/8788/28471575220_4ff8ae2c4a_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康｜腰痛快躺平、穿護腰？日醫：反而拖更久，這樣最快好"],["url","https://bit.ly/2kaEPfi"],["summary","【早安健康／張承宇報導】多數人都曾受到腰痛的困擾，原因卻常常「無知影」，問街坊鄰居，他們總是說：閃到腰？穿護腰、多多休息、貼個撒隆巴斯幾天仔就好啊啦！」，但其實，東京大學醫學部附屬醫院特任教授松平浩指出：我們以往應對腰痛的方式其實都錯了！這樣只會讓我們腰痛好得更慢，甚至更加嚴重。\n \n其實，腰痛的真正原因很難判斷，透過MRI核磁共振攝影、X光攝影可以診斷出的腰痛大約只有15％，剩下的85％原因較難釐清。\n腰痛的原因\n\n腰痛的原因有很多，松平醫師概略將腰痛的原因分成三種，並表示：腰痛先不用太過擔心，剩下的85％只要正確應對，通常不會造成太大的危害。\n\n 紅色燈號骨折、重大疾病或是神經症狀（脊柱管狹窄症、椎間盤突出症等），務必第一時間接受治療。\n 黃色燈號以為馬上會好卻持續很久的腰痛，此類腰痛其實可以快速痊癒，會造成較大影響的原因通常是患者對腰痛的不安、恐懼、壓力等心理因素，導致無法迅速恢復健康。\n 綠色燈號閃到腰等一般常見的腰痛。\n\n其中只有紅色燈號是因為明確原因造成腰痛，黃色及綠色燈號都是屬於不會造成太大危害的其他85％。\n腰痛難以痊癒？恐是心理因素導致\n \n日本針對腰痛者進行調查，結果顯示：\n\n 在腰痛後完全休息靜養的患者，腰痛時間持續3個月以上的約28.6%。\n 在腰痛後，進行和緩而可以忍受的腰部運動的人，腰痛持續3個月以上的，是0。\n\n換言之，腰痛後完全不動，竟然讓腰痛持續的時間更長。松平醫師指出，這是因為我們腰痛時產生「怎麼辦」、「腰痛怎麼還沒好啊？」諸如此類不安、恐懼的心理，會讓大腦過度反應，變得害怕疼痛而只敢安靜休養，腰部卻也因此分泌疼痛物質，造成惡性循環。\n\n\n正確抗腰痛的方式下一頁告訴您！"],["topImageUrl","https://c1.staticflickr.com/1/945/41818624942_92074e2ba2_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康嚴選"],["url","https://shop.everydayhealth.com.tw/l.php?1cfpkq"],["summary","【九月慶中秋】親友相聚送禮表心意，滿額再加贈超值好禮\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\t\t●●●●●●●●●●●●●●●●\t\t\t\t\t\n\n\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\n\t\t\n\n\n\n\n\n個資安全加密\nSSL憑證安全付款 \n\n\n\n \n\n購物滿1200元\n整筆訂單免運費 \n\n\n\n \n\n加入LINE好友\n立即現折100元 \n\n\n\n \n\n立即來電訂購 \n02-5596-7262\n\t\n\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\n\t\t\t\t\n\t\t\n\n\t\t\t\n\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tAmericanTraveler 20吋超輕量抗刮行李箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\n\t\n\t\t\n\t頭皮護理手札：為什麼洗頭髮要洗兩次？\n\t\n\t\t\n\t\t\n\t\t\t「夏季要一天洗幾次頭才夠呢？頭髮多只要一流汗頭皮癢，洗完還是悶悶的！」\n「每天都要戴著安全帽騎車通勤，長久下來頭皮長痘痘了，該怎辦呢？」\t\t\n\t\n\t\n\t\t\t\n\n\t\t\t\n\n\t\t\t「秋分」這天，太陽直射達到180度，使晝夜各12小時，此後，北半球晝短夜長，天氣漸漸轉涼，此時是調整...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t🌝【全館慶中秋9/1~9/30】月圓不圓圓，雙重獻禮送健康🌛全館消費滿額免費送鬆筋按摩器(市價399...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t8more老客人梓瑩Janet：「隨著人生一路轉折，我認識到生命就是能量的流動，心胸越開放不執著，就...\n\t\t\n\t\t\t\n\n\t\n\t\n\t\n\t\n\n\t\n\n\n\n\n\n\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t客服專線 02-5596-7262 ｜服務時間週一至週五 9:30-12:30/13:30-18:00\n\n\t\t\t©2018 早安健康股份有限公司版權所有，轉載必究 Copyright Everyday Health Co,Ltd All Rights Reserved"],["topImageUrl","https://ftp.pic.everydayhealth.com.tw/edh_upload/website_info/pic_logo_1.png?1475814226"],["error",null]]}]}],["text","(crown)比菠菜地瓜葉厲害！抗癌減重的超級食物不能錯過它\nhttp://bit.ly/2aXlVTW\n\n(frozen)腰痛躺平、穿護腰？日醫：反而拖更久，這樣最快好\nhttps://bit.ly/2kaEPfi\n\n(3 hearts)吃好油身體最知道，嚴選台灣苦茶油含茶多酚、維生素A、E、不飽和脂肪酸，烹飪直接飲用皆宜！2瓶限時9折\nhttps://shop.everydayhealth.com.tw/l.php?1cfpkq"],["id","1pwywvl7ymqxo"],["createdAt","2018-05-19T14:06:43.775Z"]]},{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_3030n4skqr0Wh7bQkJbP8gSoRVyvOsNfLVGQo4zWrbs"],["name","一本正經的琉球芝妮雅"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","不再是老年人才會罹患！如何預防突發的心肌梗塞？｜周孫立醫師｜健康連線｜早安健康"],["url","https://bit.ly/2Dz1bSs"],["summary","被稱作無形殺手的「心肌梗塞」一發作，彷彿在跟死神拔河！資深藝人馬如風、戎祥、茂伯、馬兆駿、小北百貨創辦人黃卜文、親民黨前立委馮定國等，皆因心肌梗塞而離世。最近季節交替，因溫差大，像近日早晚較有涼意，中午較高溫，有時不注意，也可能會有心肌梗塞的風險。究竟為什麼會發生心肌梗塞？又該注意什麼呢？周孫立醫師說明，通常造成心肌梗塞的原因是不會突然發生、出現的，大部分人都是因為長期不良的先天條件、不良的後天環境及不良的個人習慣造成。心肌梗塞的高危險群？\n\n有高血脂、高血壓家族病史周孫立醫師說，由於現今外在環境汙染等問題很多，就容易讓原來先天存在不良的體質，提早誘發問題，所以才會有漸趨年輕化的現象。若是發現自己的家族有相關心血管疾病的遺傳因子，就要特別注意。\n三高（高血糖、高血脂、高血壓）患者代謝及血管功能失調也是導致心肌梗塞的危險因子。\n慢性腎臟病\n先天心臟功能不全\n心臟傳導異常\n腦血管疾病，或身體其他各處血管疾病\n\n\n心肌梗塞有前兆嗎？\n周孫立醫師指出，心肌梗塞從過去至今的死亡率都很高，原因就是表現出來的症狀都不太明顯或不太專一，最常見的症狀為「胸痛」，但也有很多患者是出現其他症狀，導致錯失警訊，因此延誤就醫。此外，在某些神經功能退化的人，尤其是老人家，甚至沒有症狀。心肌梗塞症狀\n\n胸痛（大部分）\n肩膀痠痛\n牙齒痛\n胃痛\n脖子痠痛\n背痛\n呼吸短促\n未出現症狀\n\n突發心肌梗塞怎麼辦？如何治療？下一頁看醫師詳解"],["topImageUrl","https://c1.staticflickr.com/5/4821/31009133877_d75822c48c_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康｜運動前喝一杯，多減17％內臟脂肪！"],["url","https://bit.ly/2byK1YY"],["summary","【早安健康／健談】茶飲是非常常見的飲品種類之一，健爺爺每天飯後都要喝杯茶才滿足！你知道\n喝綠茶的好處有哪些嗎？快來看看吧～ \n \n \n \n1. 綠茶有助減少體脂肪 \n綠茶中含有茶多酚、兒茶素、維生素C等，有助脂肪氧化，配合飲食與運動可有效達到降脂減肥的效果。研究指出，運動前喝綠茶，能多消耗17%的體脂肪，增加運動燃脂的效果。 \n \n \n2. 綠茶能抗氧化、延緩老化 \n茶葉中的抗氧化物質EGCG可中和身體內的自由基，達到延緩老化的作用。 \n \n \n3. 綠茶有助防癌 \n綠茶中高含量的多酚可以幫助清除自由基，預防癌症。 \n \n \n4. 綠茶能抵抗輻射傷害 \n綠茶中的維生素C、兒茶素有助降低紫外線或3C用品的輻射傷害，且綠茶中的維生素A也可保護視力，預防眼睛傷害。 \n \n \n5. 綠茶有提神效果 \n綠茶中的多酚與兒茶素，有助快速恢復精神，達到提神醒腦的效果。 \n \n \n6. 綠茶能延緩骨質流失 \n研究發現，停經婦女每日攝取4~6杯茶有助延緩骨質流失，尤其喝茶時間長達10年以上者，骨質密度明顯比不喝茶者來得高。 \n \n \n7. 綠茶能降低蛀牙機率 \n茶葉中含氟、兒茶素，可減少細菌附著在齒面或停留於口腔中，降低蛀牙的機會。 \n \n茶對健康有益，但應適量攝取才能發揮最大效果，建議可在飯後喝避免刺激腸胃。另外，有特殊疾病者建議先詢問醫師或營養師適當的飲用方式。 \n \n圖文創作：健談 \n專家諮詢：高雄市立鳳山醫院營養治療科廖嘉音營養師 \n \n作者簡介：\n健談用健康漫畫方式，帶你簡單瞭解正確健康概念與疾病，讓大家一起漫漫健康～想看每日最新健康資訊嗎？請上 \n健談粉絲團\n\n綠茶還有更多健康好處，下一頁繼續看更多！"],["topImageUrl","https://farm9.staticflickr.com/8440/28395715994_80e30138d6_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康嚴選"],["url","https://shop.everydayhealth.com.tw/l-fe4cw8"],["summary","●●●●●●●●●●●●●●●●\t\t\t\t\t\n\n\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\n\t\t\n\n\n\n\n\n個資安全加密\nSSL憑證安全付款 \n\n\n\n \n\n購物滿1200元\n整筆訂單免運費 \n\n\n\n \n\n加入LINE好友\n立即現折100元 \n\n\n\n \n\n立即來電訂購 \n02-5596-7262\n\t\n\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\n\t\t\t\t\n\t\t\n\n\t\t\t\t\n\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【淨毒五郎】洗衣槽抗菌清潔劑3盒★抗菌防黴、深層去汙、天然環保\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tAmerican Traveler輕量20吋行李箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【強生】全能訓練椅CS-8606 (期間限定送訓練海報+電鍍啞鈴2kg/組)\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【Muva】美姿骨盤枕★限時加購【Muva】超彈力瑜珈墊(魅力桃)\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tFun Sport協調鍛鍊免運組-美肌塑體神拉器+Q彈有氧啞鈴\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\n\t\n\t\t\n\t金平風味椰子油炒鮮菇～省時美味料理\n\t\n\t\t\n\t\t\n\t\t\t一年四季都適合端上桌的快手料理。備料迅速、不會花太多時間，滋味香醇潤口，忙碌的時候也能好好上菜，可說是煮婦的超級好隊友。\t\t\n\t\n\t\n\t\t\t\n\n\t\t\t\n\n\t\t\t「鹽麴」是米麴、鹽、水發酵熟成的調味料，發酵的過程令鹽麴的味道多了像清酒的香氣，卻沒有酒精成份。三百...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t髮質好不好除了遺傳因素和營養因素等等的原因之外，後期的頭皮養護也是關鍵！你的日常頭皮養護做對了嗎?　...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t國曆10月23-24日是秋天的最後一個節氣─霜降。在台灣可以明顯看見樹葉轉黃，也是賞菊的好時機；氣溫...\n\t\t\n\t\t\t\n\n\t\n\t\n\t\n\t\n\n\t\n\n\n\n\n\n\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t客服專線 02-5596-7262 ｜服務時間週一至週五 9:30-18:00(12:30午休1h)\n\n\t\t\t©2019 早安健康股份有限公司版權所有，轉載必究 Copyright Everyday Health Co,Ltd All Rights Reserved"],["topImageUrl","https://ftp.pic.everydayhealth.com.tw/edh_upload/website_info/pic_logo_1.png?1475814226"],["error",null]]}]}],["text","(oh no!)4位藝人這病走了！名醫：3種食物少吃... \nhttps://bit.ly/2Dz1bSs\n\n(love)運動前喝一杯，多減17％內臟脂肪！\nhttps://bit.ly/2byK1YY\n\n(tulip)財富自由、健康到老，打造無憂人生下半場！一天不到10元，訂早安健康一年12期+今周刊一年52期加送雙好禮超值合購熱賣中！\nhttps://shop.everydayhealth.com.tw/l-fe4cw8"],["id","1fn23e8mzk1rs"],["createdAt","2019-11-07T02:26:41.996Z"]]},{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_6X-TIb4UI-5haLAzcNp68YXmc2ZZXbeYHt79kLVtuUQ"],["name","正直無私的東引李維"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","早安健康｜老是睡不飽？試試這個姿勢，10分鐘等於休息3小時！"],["url","https://bit.ly/2fyQdir"],["summary","【早安健康編輯部／編譯】每天忙碌的生活中，許多人給自己唯一的休息時間就是睡眠，最常見的是以睡眠時間為指標，希望每天可以睡滿6～8小時，讓身體得到充足休息。 \n然而你可能也發現，在加班、應酬和其他活動瓜分之下，要睡滿8小時實在太困難了！即便做到，也不見得隔天醒來就精神飽滿。我們經常掛在嘴邊的「怎麼睡都睡不飽」，指的其實就是這種睡眠時間不等於休息品質的情形。 \n日本睡眠醫學博士坪田聰於著作中指出，一旦睡眠品質不佳，體內的生長荷爾蒙就無法成功修復細胞、消除疲勞，例如100個受損細胞裡面，只成功修復或再生其中50個細胞，久而久之不僅會提早老化，生病的風險也會提高。 \n \n日本Lapure瑜伽中心指導講師森初世以自身經驗指出，現代人生活忙碌，尤其是30～40歲女性想要維持美麗與健康，更要把握僅存的夜晚時間，最有效率地達到放鬆與休息的目的，擺脫睡眠不足、睡眠品質不佳的困擾。 \n想要在有限的時間裡完全放鬆，不妨嘗試瑜伽姿勢「大休息」（SAVASANA，又名「攤屍式」）。森初世表示，只要維持整個人平躺的「大休息」姿勢10分鐘，就能達到平常休息2～3小時的效果，是短時間內迅速恢復體力的首選！ \n森初世也建議，進行「大休息」時要盡量讓頭部、眼睛、肩膀、指尖等身體各部位放鬆，同時想像全身不斷往下沉，直到緊貼地面。另外，事先將室內燈光調暗，有助於放鬆心情，也可以準備薄毛毯保暖，避免感冒。 \n瑜伽「大休息」姿勢這樣做＞＞ \n1. 仰躺，雙手置於身體兩側，手心朝上，雙腳打開與骨盆同寬。2. 閉上眼、緩緩呼吸，維持10分鐘。 \n森初世認為，進行「大休息」時，最理想的是維持在快要睡著卻沒有睡著的朦朧狀態，但是太舒服而睡著了也沒有關係。因為瑜伽「大休息」姿勢不僅能消除一整天的疲勞，也有助於進入熟睡狀態、增進睡眠品質。 \n下回覺得睡不飽時，無論是想要短時間恢復精神，或是睡前助眠，都不妨試試這個簡單的姿勢，短短10分鐘就可以睡得健康又美麗。【同場加映】老是睡不飽、常脹氣都是肝臟求救訊號！多吃4類食物養好肝早上起不來？白天曬太陽、傍晚動一動，3招讓睡眠更有效率練核心！只要一個動作，擺脫小腹粗大腿"],["topImageUrl","https://farm6.staticflickr.com/5718/22717634527_ff87853145_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康嚴選"],["url","https://shop.everydayhealth.com.tw/l-1dnp8g"],["summary","關於早安健康嚴選\t\t \n\t\t常見問題聯繫我們登入/註冊\t\n\n\n\n\n\t\n\t\t\n\t\t\t\t\t\n\t\t\n\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t免運防蚊拉筋板\n\n\t\t\t\n\t\t\n\t\t\t\t\n\t\t\t 0 個商品\t\t\t\n\t\t\n\t\n\n\n\n\n\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t嚴選推薦運動塑身健康飲食生活良品雜誌熱門專欄\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\n\t\t\t\t\t\n\n\n\n\n\n\n\n\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\n\t\t\n\t\t\t\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t【挑戰年底最低價】花蓮立閣人文旅店超值住宿優惠再送早安健康一年份\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\t\t●●●●●●●●●●●●●●●●\t\t\t\t\t\n\n\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t購物金改制\n\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tLINE好友獨享\n\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\n\t\t\n\t\t\n\n\n\n\n\n個資安全加密\nSSL憑證安全付款 \n\n\n\n \n\n購物滿1200元\n整筆訂單免運費 \n\n\n\n \n\n加入LINE好友\n立即現折100元 \n\n\n\n \n\n立即來電訂購 \n02-5596-7262\n\t\n\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【昌豐】日本原裝唐辛子保健貼布(2入)\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$89 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【muva】美姿骨盤枕★日本骨盤瘦身達人推薦！\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$1,380 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【萃綠】檸檬果膠代謝酵素750ml\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$1,580 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t金笛柚子醋醬油150ml\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$200\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【順天堂】溫心好薑★原薑切片真材實料\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$150\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【順天堂】珍品枸杞王★市售唯一入藥典品種，品質超群\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$240 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【薌園】黑芝麻粉350g\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$180\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【Fun Sport】纖腰扭扭盤-足按摩款 (轉盤/腰扭盤/扭腰盤/妞妞盤)\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$699 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【萃綠】檸檬酵素精萃液(20mlx12瓶)\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$1,200 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【果物配】台灣酪梨-友善農法(濃郁滑順．超大顆/3公斤)★CP值超高，好大一顆梨！\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$749 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【超值免運組】金笛再釀造生醬油+柚子醋醬油\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$800\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【薌園】燕麥糙米豆漿32g x 12入\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$145\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【特級草莓禮盒】有機(轉)《送禮最大器．每箱40入》\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$899 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【居家檢測】水保鏢–水質檢測2入\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$1,500 組合價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【生態綠】100%純可可粉*1+純黑巧克力片*5\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$1,200 組合價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【薌園】紅豆紅薏仁粉500g\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$380\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【智利櫻桃】空運直送《深紅大顆超過癮 /1公斤》\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$899 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【食在加分】Brown Sweetie手工柴燒黑糖立袋(3袋組)\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$576 組合價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t《早安健康》一年12期 + Pockeat大食袋(3L)\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$1,480 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t可可威達初榨椰子油443ml+生態綠純黑即溶咖啡30入\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$820 組合價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\n\t\t\t\t\t\n\t\t\t\t\n\n\t\t\t\t\n\t\t\n\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t\n\n\t\t\n\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【muva】美姿骨盤枕\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t日本三合一美型舒筋板\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【強生】Cozy肩頸6D按摩\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【muva】健康趾力鞋\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t草本防蚊液*3＋防蚊包*10/箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t台灣在地養生特A級黑蒜\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【菇王】有機鹽麴\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【生態綠】可可組合\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t品諾14吋全方位DC直流馬達四季循環扇\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\ttokuyo型男美女提臀健腹機\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t檸檬白木耳淨透雙享組\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tMCT防彈咖啡隨身包入手組\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tcity traveler可加大18吋行李箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t勳風加熱式氣泡按摩足浴機\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tAmericanTraveler 20吋超輕量抗刮行李箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t鍋寶養生燉鍋1.8L +1元送友半年雜誌\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t《逆轉脂肪肝》\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t《有氧治百病：呼吸》\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t《排腸毒，不失智不罹癌》\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t《膝關節自癒術》\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t日本三合一美型舒筋板\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【Fun Sport】纖腰扭扭盤\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【muva】美姿骨盤枕\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tFun Sport美肌塑體神拉器\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【origins foodist】近江糯麥\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【薌園】堅果糙米脆果\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【薌園】高纖豆漿\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【生態綠OKO】綠咖啡\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\n\t\t\n\t清涼迎夏三部曲\n\t\n\t\t\n\t\t\n\t\t\t清涼迎夏三步曲\n簡單三步驟炎夏輕鬆擁有蓬鬆清爽的秀髮\t\t\n\t\n\t\n\t\t\t\n\n\t\t\t\n\n\t\t\t一年四季都適合端上桌的快手料理。備料迅速、不會花太多時間，滋味香醇潤口，忙碌的時候也能好好上菜，可說...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t國曆10月23-24日是秋天的最後一個節氣─霜降。在台灣可以明顯看見樹葉轉黃，也是賞菊的好時機；氣溫...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t人體為維持正常機能，除了五大營養素之外，還增加了膳食纖維與植化素；綠原酸即是植化素之一。綠原酸（Ch...\n\t\t\n\t\t\t\n\n\t\n\t\n\t\n\t\t\t\t大家最愛搜\n\t\t\n\t\t\t冷離心初榨暖暖包防蚊牛蒡茶【曼髮妮】天然染髮粉有機系列c5拉筋版，拉筋板，拉筋，拉筋板哪裡買，拉筋板推薦韃靼蕎麥燉鍋堅果泡腳機染髮綠藤亞麻籽油檸檬片高纖豆漿智利櫻桃【muva】3D蝶型纖體機瘦小腹口罩甜菊芝麻除體濕紅薑黃黑糖椰子油純可可粉哪裡買紅棗預防乳房籤維仁三樂事酪梨油維他命天然維他命高鈣黑芝麻美姿骨盤枕曼髮妮可可粉失智隨行杯豆漿助眠正髖關節苦茶油薑更年期消水腫tokuyo茶Sastty】染髮不過敏日本利尻昆布白髮染髮劑200g 黑色骨盆枕蝶豆花甜菜根洛神花紅茶清爽運動組防彈咖啡手工柴燒純黑巧克力亞麻仁油wp3922脊椎AS 快眠止鼾枕富含Omega-3十段活絡拉筋板瘦生酮飲食鬆筋按摩器黑巧克力鬆筋按摩可可純可可 100％純可可大輝可可無糖巧可力無糖可可拉筋板發現茶無花果天然染髮排腸毒艾草純可可粉咖啡順天堂肉桂黑豆蝶豆花茶枸杞薑黃益生菌堅果樂園熱敷墊紅薑黃冷壓亞麻籽鬆筋膜救疼痛鞋墊健腹器蝴蝶圈鴻參橄欖油南非國寶茶森林蜜脂肪肝排毒腳底按摩可可菇王鹽麴哪裡買，鹽麴，鹽渠，菇王染髮劑菊花茶、杭菊、茶包\t\t\n\t\n\t\n\n\n\t\n\t\t\n\n\t\t訂閱\n\t\t\t \n\t\t\t取消\n\t\t\n\t\n\t\n\t\t「早安健康嚴選」將定期透過電子報發送新品通知及最新優惠訊息，\n想要得到本站的第一手資訊嗎 ?\n快點留下信箱訂閱我們的電子報吧 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Reserved"],["topImageUrl","https://ftp.pic.everydayhealth.com.tw/edh_upload/website_info/pic_logo_1.png?1475814226"],["error",null]]}]}],["text","(dozing)老是睡不飽？試試這個姿勢，10分鐘等於休息3小時！\nhttps://bit.ly/2fyQdir\n\n(ok)骨盆正了就會瘦！日本骨盤瘦身達人福辻鋭記推薦骨盤枕，輕鬆找回迷人腰線！雙12特價1212免運最後一天\nhttps://shop.everydayhealth.com.tw/l-1dnp8g"],["id","2ssg9fuzt61bx"],["createdAt","2018-12-14T06:05:40.999Z"]]},{"__iterable":"Map","data":[["replyCount",2],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_FxFJOU0PYt-POeEuxROBISc5mmlqOB1LN_rl2wHWgKY"],["name","理智的萬榮納特"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","全球最大纪录片节送福利，300余部影片免费在线观看"],["url","https://mp.weixin.qq.com/s/_uP9xUg0hV_JhkVgLuExVQ?fbclid=IwAR0FX3JExpQPd9Wzpuq5FTo4VAzUeyNkOLdj3oWgN_Gkav5sVugCa7g9Jmw"],["summary","今天要为大家推荐一份属于影迷的福利，全球最大的纪录片影展阿姆斯特丹纪录片节（idfa）在其官网放出300部以上全球纪录片供在线观看，如果你注册为会员还可以增加至500多部，可按国家，类型进行选择。链接直达：https://www.idfa.nl/en/info/watch-films-online-1?from=timeline&isappinstalled=0作为idfa的主办国，荷兰也遭受新冠疫情打击，目前荷兰已经有804例确诊患者，累计死亡10人。荷兰也严重缺乏医疗物资，目前已有大量医护人员感染，荷兰南部医护人员接受了检测，结果显示大约有4%的医护人员感染了新冠病毒。idfa放出数百部纪录片，也似乎是效仿欧洲部分美术馆，博物馆开放在线浏览的形式，意在鼓励民众留在家中，减少外出，而真正喜欢纪录片的影迷也可通过流媒体观看，规避电影院或影展观影的潜在疫情风险。2020年阿姆斯特丹纪录片节原定11月18日至29日进行，暂未宣布延期。位于荷兰阿姆斯特丹的IDFA创立于1988年，是迄今为止世界上最大的纪录片节。每年，IDFA都会展示全世界范围内挑选出的纪录片佳作。中国自1996开始便有作品入选IDFA，到2017年，总计有近百部纪录片被影展收录，包括周浩，杜海滨，徐童，顾桃，范俭等众多如今仍活跃在影坛的纪录片导演都曾有作品在IDFA入选，IDFA参与见证了新千年以来中国纪录片，尤其是中国独立纪录片的发展与成长。下文按年份整理出全部以“中国大陆”为制片国入选IDFA的纪录片，部分中国导演的作品以海外及港台报名影展（如王兵的《孤独》（2013）代表香港参展），本文未做收录。1996～2019，中国百部入围阿姆斯特丹纪录片节作品盘点2019年度2019年度入围作品为今日刚刚公布，多部华语纪录片入选各单元IDFA主竞赛单元：First Appearance竞赛单元韩萌《Smog Town》80分钟IDFA展映类单元：Frontlight 展映单元贾玉川《The Two Lives of Li Ermao》87分钟孙扬，江松长《时光机》81分钟张侨勇（加拿大华裔）《这不是一部电影》107分钟Luminous 展映单元《游神考》81分钟IDFA DocLab Spotlight单元Chien HuangVR实验纪录短片《失身记》31分钟官网完整入围片单：http://t.cn/Ai1PqG9j2018年度世外桃源The Land of Peach Blossoms周铭影Mingying Zhou | China | 2018 | 99minFirst Appearance竞赛单元火山Up the Mountain张杨Yang Zhang | China | 2018 | 126min长片竞赛单元红毛皇帝Dancing in the wind岳廷Ting Yue | China | 2018 | 89min学生竞赛单元死灵魂Dead Souls王兵Bing Wang | China／France／Switzerland | 2018 | 496min大师展映单元我的镜头Chinese Portrait王小帅Xiaoshuai Wang | China | 2018 | 90min大师展映单元安妮AnniRikun Zhu | China | 2018 | 78min佳片展映单元大字Big Characters雎安奇Anqi Ju | China | 2015 | 15min艺术展映单元Trapped in the City of a Thousand Mountains戴霍 DavidVerbeek短片竞赛单元IDFACompetitionforShortDocumentary2017年度二十四号大街 24th Street 潘志琪 Zhiqi Pan| China | 2017 | 88 min长片竞赛单元惊蛰 Awaken 宁佳伟｜中国｜2017｜63min中片竞赛单元行走敦煌 The Cave 赵琦｜中国｜2017｜13min纪录片实验竞赛单元芳舟 Lady of the Harbour 王申｜荷兰、中国｜2017｜95min荷兰竞赛单元团鱼岩 Turtle Rock 萧潇｜中国｜2017｜101min新人竞赛单元2016年度中国梵高 China's Van Goghs余海波 Haibo Yu, 余天琦 Kiki Tianqi Yu 2016 81 minA Chinese replica painter feels a deep affinity with Van Gogh and travelsto Amsterdam to find the spirit of his own work.俺爹俺娘 My Father and My Mother焦波 Bo Jiao 2016 88 minThe life of a simple Chinese couple, documented in thousands ofphotographs and many hours of video footage taken over a 30-yearperiod by their son, a well-known photographer.塑·料·王·国 Plastic China王久良 Jiu-liang Wang 2016 81 minYi Jie and her family live next to a primitive recycling plant. Her worldconsists of mountains of plastic waste from Europe, the United States andAsia.摇摇晃晃的人间 Still Tomorrow范俭 Jian Fan 2016 88 minDisabled by cerebral palsy and unhappily married, the painfully frankXiuhua Yu makes a dramatic breakthrough as a poet. Will fame solve herproblems?欢迎 Welcome朱日坤 Rikun Zhu 2016 63 minA raw and disturbing document that exposes the methods of the Chineseauthorities by allowing them to speak uncensored.2015年度大同 The Chinese Mayor周浩 Hao Zhou2015 87 minThe mayor of the Chinese city of Datong embarks on an immensedemolition and building project to transform his city into a touristattraction.我的诗篇 Chinese Verses吴飞跃 Feiyue Wu, 秦晓宇 Xiaoyu Qin2015 96 minChinese factory workers use poetry to break with their anonymity incandid expressions of their feelings and their hardships.对看 Look Love叶云 Yun Ye2015 146 minTwo Chinese children, one dirt poor, the other filthy rich. They both longfor affection, but neither have parents who can offer it. 我只认识你 Please Remember Me赵青 Qing Zhao2015 78 minAn elderly couple in Shanghai gracefully struggles with age, illness andmemory loss.大路朝天 The Road张赞波 Zanbo Zhang2015 95 minThe construction of a gigantic highway in China puts three parties at oddswith each other: local residents, the construction company and thelaborers.少年小赵 A Young Patriot杜海滨 Du Haibin2015 106 minAn intriguing portrait of a young Chinese nationalist who sees many of hisideals dashed over time.2014年度棉花 Cotton周浩 Zhou Hao2014 83 minMillions of Chinese farm laborers work in the cotton industry. The factoryprovides regular jobs, but is having to live so far from home really worthit?我就是我 I Am Here范立欣 Lixin Fan2014 88 minIDFA Award winner Lixin Fan follows the rite of passage of contestants inSuperboy, a Chinese talent competition for boys.铁西区 Tie Xi Qu: West of the Tracks王兵 Wang Bing2002 554 minA nine-hour meditative masterpiece about the decline of China’s biggestand oldest industrial area, and the consequences for the remainingworkers.2013年度四哥 The Fourth Brother徐童 Tong Xu2013 86 minAn intimate black-and-white portrait of an ex-con getting back to his oldtricks after spending half his life in jail.妈妈的村庄 Mothers许慧晶 Huijing Xu2013 70 minWoman's Care, the birth control center in a small Chinese village, startscracking down on women required to undergo sterilization.梦与影 Playing with Shadows牛小雨 Xiaoyu Niu2013 52 minIn a final attempt to turn his hobby into a job, passionate shadowpuppeteer Li Zi signs up for a TV talent pageant.查房 The Questioning朱日坤 Rikun Zhu2013 21 minThe human rights activist Rikun Zhu opens his door and is confronted bya horde of policemen – luckily he has a camera running, which they don’tnotice.Tiger MountainJie Wu2013 60 minThis moving film gives a voice to the residents of a village in the Chinesecountryside that has been polluted by the coal mining industry and nowreceives no attention whatsoever from the authorities.2012年度千锤百炼 China Heavyweight张侨勇 Yung Chang2012 93 minAn observational documentary on the rise of the Western sport of boxingin China. Will the young talents fight for their country, or themselves?出路 Education, Education陈为军 Weijun Chen2012 58 minDirector Chen Weijun uses three stories of young Chinese people to tell abigger story about the country's failing education system.殇城 Fallen City赵琦 Qi Zhao2012 88 minThree damaged families live in great sadness following an earthquake thathit the Chinese city of Beichuan, while a few miles from the rubble, a newcity is being built.革命是可以被原谅的 Fidaï丹米阳 Damien Ounouri2012 83 minA personal tale of an Algerian revolutionary, this is a story about fightingfor independence - both now and 50 years ago.归途列车 Last Train HomeLixin Fan2009 85 minKeeping the family together is the toughest job of all for the workers ofthe factories of a changing China, who only see their children on NewYear.2011年度死囚其言 Dead Men TalkingRobin Newell2011 52 minEvery year, about a thousand condemned prisoners are executed inChina. Just before their execution, journalist Ding Yu interviews some ofthem for her popular TV show.活着 The Next Life范俭 Fan Jian2011 54 minA Chinese couple whose only child died in the 2008 earthquake turn tomedicine to get pregnant again.最后的春光 The Vanishing Spring Light餘迅 Xun Yu2011 112 minThe lives of the inhabitants of West Street in Dujiangyan City, and inparticular Grandma Jiang, on the eve of radical urban renewal.2010年度2008·纪 Beijing 2008雷建军 Lei Jianjun2010 90 min2008 turns out to be a special year not only for the city of Beijing, wherethe Olympic Games are being held, but also for a resident of the citynamed Ji.殻 Crust黄文海 Wenhai Huang2010 13 minThe story behind the industrialization of China remains as mysterious asthe ghostly figures at the shipyard on the Yangtze River, working to aclaustrophobic soundtrack.海上传奇 I Wish I Knew贾樟柯 Jia Zhang Ke2010 138 minA poetic portrait of Shanghai that captures the present in images and thepast in the personal stories of its inhabitants.2009年度世界最大的中国餐馆The Biggest Chinese Restaurant in the World陈为军 Weijun Chen2008 80 minA film portrait of modern China as viewed through the prism of staff andguests at the largest Chinese restaurant in the world.采花大道 Gipsy in the Flower雎安奇 Anqi Ju2009 60 minA bittersweet portrait of a couple of Chinese beekeepers, who travel10,000 kilometers each year to places where the flowers bloom.贾医生的100个病人 A Hundred Patients of Dr. Jia王洪军 Wang Hongjun2009 105 minHectic scenes in Dr Jia's office. The comings and goings of patients and thepeople they bring along evolve into a charming group portrait.灯塔 Lighthouse殷子静 Chi-Jang Yin2009 16 minA portrait of the nocturnal existence of anonymous Chinese laborers whofight, smoke, play cards, and work, often without knowing that the camerais rolling.上言方 Petition赵亮 Zhao Liang2009 124 minThe inhabitants of Petition Village in Beijing and their daily struggle forjustice against the indifference of the Chinese totalitarian state.2008年度淹没2 Before the Flood II鄢雨 Yu Yan2008 60 minThe residents of a 1,700-year-old Chinese village are dumbfounded whenthey learn that the construction of a reservoir will put their homesunderwater.马夫 Horsemen吴慕清 Nancy Muqing Wu2008 98 minDaily life in the historic Chinese town of Songpan, where tourists makebreath-taking horse treks while the inhabitants are toiling away.老安 The Love of Mr An杨荔钠 Lina Yang2007 79 minAn elderly Chinese man falls in love with his dance partner, who is 30years his junior, but in the meantime has a furious wife waiting for him athome.2007年度红日风暴 Storm under the SunXiaolian Peng, S. Louisa Wei2007 170 minChairman Mao Zedong's deity status was achieved by destroying theautonomy of Chinese intellectuals through a series of political \"storms.\"木帮 Timber Gang于广义 Guangyi Yu2006 90 minLumberjacks in a mountainous area of China use a lumbering method thathas not changed for centuries. This film follows them during their lastwinter on the mountain.伞 Umbrella...杜海滨 Du Haibin2007 93 minIn five chapters, we see socially-defined Chinese groups of people duringtheir labour-intensive attempts to join in with the growing prosperity inChina.龙哥 Using周浩 Zhou Hao2007 145 minA hard-boiled portrait of a Chinese junkie; in Ah Long's mind, everyoneuses everyone else, albeit for different purposes.2006年度Amphibious (Login-Logout)Jennifer Allora, Guillermo Calzadilla2005 6 minA group of turtles rides atop a log as it drifts slowly along the fastamphibious network of import and export activities on the Pearl River inChina.The Big FamilyHuang Lingping2005 82 minA harrowing documentary soap about a rural family that is ruinedbecause of the patriarch's narrow-mindedness and incapacity.Change of ChoiceChen Ling2005 53 minAn account of the onerous, but sorely needed establishment of anagricultural co-op in a farming community dominated by different familyclans.村民影像计划 China Villagers Documentary Project张焕财、贾之坦等 Nong Ke, Zhang Huancai, Wang Wei, Zhou Cengjia, Shao Yuzhen, Ni Lianghui, Sqrolma Tshe Ring, Jia Zhitan, Fu Jiachong, Chujian Yi2006 95 minTen Chinese villagers make short films to document how the Chinesecountryside is struggling with democratic reforms.城市场景 City Scene赵亮 Zhao Liang2005 23 minA string of bizarre scenes from daily life in Beijing, a city in a state ofconfusion.达官营 Daguanying汤晓亮 Tang Xiaoliang, 刘珏欣 Liu Juexin2006 75 minThe elderly residents of an exclusive neighbourhood in Beijing are drivenout of their homes by the excavating machines of project developers.在城市里跳跃 Dancing in the City范俭 Fan Jian2006 118 minA portrait of four young Chinese people who leave their dead-end lives inthe countryside to build a new identity in Beijing.靖大爷和他的老主顾们 Grandpa Jing and His Old Customers施润玖 Shi Runjiu2003 55 minAn atmospheric homage to an 87-year-old barber named Jing. In an oldneighbourhood of Beijing, he reflects on life with the elderly customers hevisits.I Want a New HomeWang Dafei2005 24 minTingting is 10 years old. She resides on a small fishing boat, but wouldrather live in a real house.董家渡 Lotus Ferry周洪波 Zhou Hongbo2006 60 minA light-hearted and agile exploration of a busy old district of Shanghaisings of small, everyday worries and pleasures.在江边 Return to the Border赵亮 Zhao Liang2005 56 minChinese director returns to the Ya Lu River that separates China fromNorth Korea to see what is left of socialism in the two countries.高三 Senior Year周浩 Zhou Hao2005 95 minA detailed account of the pressures that high school seniors and theirteachers must cope with in the ruthless and conservative Chinese schoolsystem.石山 Stone Mountain杜海滨 Du Haibin2006 123 minThis visually stunning documentary on the struggle of miners in theBeijing province provides us with dramatic insight into the lives ofworkers in today's China.TransformationYang Gancai, Wang Yi2006 120 minAn enchanting portrait of a primitive agrarian community in the Chineserainforest. What happens when these lively, self-mocking people meetmodern civilisation?2005年度A Day to RememberLiu Wei2005 13 minWith one simple question, the filmmaker demonstrates that the studentuprising at Tiananmen Square is still a taboo subject in China.Growing UpChang Yu, Wang Dongdong2004 58 minAccount of the rigorous training of underprivileged Chinese children tobecome professional acrobats in a 2000-year-old tradition.Try to Remember钟键 Jian Zhong2005 90 minA son films his mother in the village where she grew up and hears storiesabout her childhood, which was dominated by poverty and the CulturalRevolution.2004年度嵌入肉体的城市 The Concrete Revolution郭小橹 Xiaolu Guo2004 60 minChinese writer and director comments in word and image on the price thenew China pays for joining the outside world.喧哗的尘土 Floating Dust黄文海 Wenhai Huang2004 111 minThe trials and tribulations of young unemployed adults in the Chinese cityof Yaoyang.碧色车站 Jade Green Station于坚 Yu Jian2003 122 minIn very little time, the sleepy village of Bise in China became a livelymeeting place after the construction of a railroad there.七月 July张虹 Tammy Cheung2004 80 minMassive protest march in Hong Kong against proposed new legislationthat would limit freedom.Separation and ReunionZhou Yu2004 41 minThe marriage registration office of the Dalian Xigang District in China. Asa hidden witness, the camera records the intimate stories of differentcouples in the midst of divorces and reunions.Travels by TricycleWang Dongdong2003 39 minA man takes his 98-year-old mother on a journey across China in atricycle trailer.2003年度被子 Quilts雎安奇 Ju An Qi2003 92 minThe filmmaker travels through China in search for intriguing quilts andthe stories of the people sleeping under them.好死不如赖活着 To Live Is Better than to Die陈为军 Weijun Chen2003 90 minSaddening portrait of a Chinese farmer’s family that tries to live with HIV– a result of the trade in blood in the nineties.2002年度Floating MemoryLiu Wei2001 10 minFormer revolutionary loses grip on memories of the Chinese uprising of1989.当兵 Interesting Times - Shao's Long March康健宁 Y. Gong2002 39 minShao Zhenning’s first three months in the Chinese People's LiberationArmy, transform him from a useless dropout into a spirited soldier.拎起大舌头 Interesting Times - The Secret of My Success段锦川 Jinchuan Duan2002 59 minIn Fanshen village, China - birth control policy leads to an unusual turn ofevents in the upcoming village council elections.爱情战争 Interesting Times - The War of Love段锦川 Jinchuan Duan, 蒋樾 Yue Jiang2002 39 minLove in China, depicted by scenes from the life of an amateurmatchmaker-cum-divorce lawyer-cum-unhappy wife.幸福生活 Interesting Times - This Happy Life蒋樾 Yue Jiang2002 94 minAn atmospheric and absurd film about Zhengzhou, China’s busiest trainstation, and two of it it’s employees - Mr. Fu and Mr. Liu.希望之旅 Railroad of Hope宁瀛 Ning Ying2001 52 minFor meagre wages, poor wretches travel across China for three days,meanwhile dreaming of a little money, a little happiness and a decent life.2001年度A Man With HIVTong Li1999 49 minAfter volunteering as a blood donor, the HIV virus is found in 31-year-oldLi Ziliang. He is immediately fired by his boss for fear of infection. Everytime he walks on the street, he is surrounded by groups of people thatstare at him. ‘One touch and you’re finished’, one of them thinks. ‘Peopl…居委会 Neighbourhood Committee张同道Tongdao Zhang2001 49 minIn China, neighbourhood committees play an important role in everydaylife. The committees arrange things for the local residents, they areintermediaries for government plans and they solve neighbourhoodquarrels. They also maintain order and monitor family planning. Since …纸飞机 Paper Airplane赵亮 Zhao Liang, Fan Jun Yi2001 90 minThey play in punk bands with names like Brain Failure Band and AnarchyJerks Band, and regularly stick needles in their arms. Once, rebellionspurred a group of Chinese youngsters who call themselves the HundredFlowers Club to start making music (‘Ignore taboos and rules!’), but no…RevengeMa Jia, Naotomo Umewaka2009 63 minTaking the form of a detective story, this documentary reveals the facts ofthe case of the kidnapping of a young mother, whose age is kept vague fora long time. On 1 April 2000, her brother reported the abduction ofMing’e, who was being forced to marry a farmer. The police liberated h…挣扎 Struggle舒浩仑 Shu Haolun2001 50 minThe city of Shenzhen, close to Hong Kong, was designated a SpecialEconomic Zone in the 1980s, a measure aimed at stimulating the localeconomy through reduced labour costs. This growth is taking its toll,however: every year, ten thousand migrant workers are injured perfor…城乡结合部 Where City and Country Meet张战庆 Zhang Zhanqing2001 90 minAround Beijing, some one million labourers from the Chinese countrysidelive in appalling conditions. Taking one family as an example, directorZhang Zhanqing shows the hopes and problems of living on the fringes ofprosperity. His film is not a social indictment; indeed, by following a frie…2000年度My GrasslandNing Cao1999 23 minOne year in the life of a family that lives on the Mongolian steppes.北京的风很大 There's a Strong Wind in Beijing雎安奇 Ju An Qi1999 48 minCamera crew asks passers-by in Beijing the nonsensical question, ‘Do youthink Beijing’s wind is strong?’1999年度疯狂英语 Crazy English张元 Zhang Yuan1999 90 minHilarious portrait of Li Yang, a Chinese teacher who teaches English tolarge groups of fellow-countrymen.江湖 Jiang Hu: Life on the Road吴文光 Wu Wenguang1999 149 minAccording to the ‘health inspection’, a travelling Chinese show smudgesthe streets of Beijing.婚事 Jiehun梁碧波 Bibo Liang1999 80 minIn China, the marriage ritual consists of six stages that must be completedaccording to the rules.The Elders季丹 Dan Ji, 苏青 Su Qing1999 60 minTibetan village elders pray, converse and resign themselves to theapproaching death.1998年度三节草 Home-coming in Granddaughter梁碧波 Bibo Liang1997 58 minElder woman returns to her native city Chengdu after 53 years.回到凤凰桥 Out of Phoenix Bridge李红 Hong Li1997 110 minFour girls who live and work together in Beijing talk about dreams, fearsand expectations with regard to their marital future.1996年度往事歌谣 Wang shi ge yao郑鸣 Zheng Ming1995 90 minFilm about the life and artistic career of old Wang Luobin, whose whole lifewas dedicated to collecting and performing folk songs from NorthwestChina. SONGS OF THE PAST takes the legendary musician to the place ofhis youth, where he brings back memories of the past and talks about hi…纪录片在荷兰一直是广受欢迎的艺术形式，一年一度的阿姆斯特丹国际纪录片电影节吸引了全球杰出纪录片电影人参展，将世界上每个角落的真实影像展现在银幕前，让观众无法再继续对长久被他们忽略的问题视而不见。无论是春运赶回家过年的中国民工，还是现代都会里饱受恐慌症之苦的阿姆斯特丹居民，纪录片导演们借由影像呈现现代生活的焦虑与无奈，讲述人们在逆境中找到光明与希望的真实故事。深秋的阿姆斯特丹阴雨绵绵，街头难得地显得冷清，顶着雨缩着颈项的行人面目严峻，然而一走到阿姆斯特丹著名的娱乐休闲区伦勃朗广场，一股来自异国的新鲜空气扑面而来。阿姆斯特丹国际纪录片电影节的宣传旗飘扬在各个街角，3000多名来自世界各地的电影爱好者、电影人和媒体记者用不同的语言表达他们对影片的观感，交换在不同国家和文化中拍片的心得。电影节创立于1988年的阿姆斯特丹国际纪录片电影节（IDFA，International Documentary Film Festival Amsterdam，19-29 Nov.）原本只是一个小型的电影活动，21年来逐渐演变成国际上最大型的纪录片盛会之一，今年更有近2500部纪录片参展。强调原创性与创意，阿姆斯特丹国际纪录片电影节在选片时特别注重影像工作者的个人观点与特殊的摄影与制作形式，虽然展出影片相当国际化，阿姆斯特丹纪录片电影节也开始重视本土的视野，在今年首度推出以荷兰纪录片为主的“低地”电影节大赛（Lowland），电影节主席Ally Derks表示：“我们希望这能够为维持荷兰丰富的纪录片传统做出一点贡献！”除此，阿姆斯特丹国际纪录片电影节也担负起推广纪录片艺术形式的重责，刚推出的“纪录片市场”（Docs for Sale）计划帮助纪录片导演寻找买主与展映机会，而有17年历史的the FORUM则是国际纪录片制片人与导演交流讨论、寻求财务支援的最佳场所；另外，成立于1998年的Jan Vrijman Fond更帮助了数百位发展中国家的电影人实现拍片梦想，中国导演范立欣就是获得Jan Vrijman基金奖助的幸运儿之一。纪录片节征片时间及费用以2019年为例2019.5.1（2018.8.1至2019.4.30完成的作品）2019.8.1（2019.4.30后完成的作品）费用：50欧元（不含增值税）征片要求1.非英语影片需有英文字幕。2.若作品的粗剪版本被拒绝，则不能在本届或下届电影节再次投递其更新版本。3.参选者应防止作品外泄。4.报名费用不予退还。5.长片作品在70分钟以上，中长片在40-70分钟内，短片不超过40分钟。学生纪录片单元无时长限制。6.需为世界/国际/欧洲首映作品，优先考虑世界首映。投递学生纪录片单元的作品可为荷兰首映。7.新人单元需提交导演的第一部作品。8.报名前至多在两个电影节或电影市场进行过放映。欧洲内进行市场放映需要得到电影节许可。9.允许在本国院线或电视进行放映，但曾经以互联网、流媒体、DVD等形式传播过的作品不可投递。投递方式在电影节官网https://www.idfa.nl/en/注册账号，填写申请表格，上传screener试看文件。投递单元及奖项设置纪录长片纪录中长片纪录短片新人纪录片学生纪录片最佳纪录长片纪录长片评审团特别奖最佳新人奖新人评审团特别奖最佳纪录中长片纪录中长片评审团特别奖最佳纪录短片纪录短片评审团特别奖最佳学生纪录片学生纪录片评审团特别奖观众选择奖Mediafonds基金纪录片奖IDFA最佳女性导演奖DocLab多媒体叙事奖DocLab浸入式纪实纪录片奖联系方式官网：https://www.idfa.nl/en/邮箱：info@idfa.nl电话：+31 20 6273329地址：International Documentary Film Festival AmsterdamFrederiksplein 52 1017 XN Amsterdam The Netherlands阿姆斯特丹国际纪录片影展也提供一个独立、激发灵感的交流平台，让观众与业界人士可以欣赏多元化及优质的影片。从纪录片形式、内容与导演的文化背景即可看出影展丰富多元的特质。除了主流娱乐、单一电影类型之外，IDFA 提供另一种影片选择以因应观众对于优质、发人省思的电影逐渐增加的需求。从2007 年开始，IDFA 的新媒体单元和纪录片实验室展示极佳的互动式、非剧情类的故事叙述，并探讨数位革命如何重塑纪录片的美学。除了影展之外，IDFA 已发展多样专业活动，协助处于各个发展阶段中的导演及其影片成长萌芽。在跨国跨资制片市场展上，参展导演与制作人向赞助商竭力推销自己的拍片计画；而在纪录片买卖市场展，许多刚出炉的纪录片供节目买家和片商挑选。伯莎基金为资助开发中国家的导演和纪录片拍片计画，IDFA 学院则专门训练全球新锐纪录片导演。📎过去10年，全球最佳纪录片110部交易担保实验影像中心实验影像中心·策展单元 Mini Program 「导筒」微信号 directube2016 📎庆祝“举报问题”被广泛讨论，导筒手机壳买一赠一📎异业合作 | 导筒2020年文末广告位招募推广/合作/活动加微信号：directubeee"],["topImageUrl",null],["error",null]]}]}],["text","新冠疫情期間的最大享受😄\n\n一份屬於影迷的福利，全球最大的纪录片影展阿姆斯特丹纪录片节（idfa）在其官网放出300部以上全球纪录片供在线观看！\n如果你注册为会员还可以增加至500多部，可按国家，类型进行选择。\n\nhttps://mp.weixin.qq.com/s/_uP9xUg0hV_JhkVgLuExVQ?fbclid=IwAR0FX3JExpQPd9Wzpuq5FTo4VAzUeyNkOLdj3oWgN_Gkav5sVugCa7g9Jmw"],["id","25ypo7x9o4nkv"],["createdAt","2020-03-20T15:32:08.879Z"]]},{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_8SU6w_lKU8142Pd-hyVJRULJNF7mjehuE3om7Vc6i8c"],["name","滿足的✖東勢✖艾薇拉"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","Diabetes drug is promising Alzheimer's treatment after 'significantly reversing' memory loss"],["url","http://www.independent.co.uk/news/health/alzheimers-diabetes-drug-memory-loss-reverse-disease-treatment-degenerative-a8133681.html"],["summary","A drug developed for type 2 diabetes significantly reverses memory loss and could have potential as a new treatment for Alzheimer’s disease and other neurodegenerative diseases, scientists say.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n The study, by UK and Chinese universities, is the first to look at a new combined diabetes drug and found improvements in several characteristic symptoms of Alzheimer’s.\n \n\n \n \n \n \n \n\n\n\n \n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n Lead researcher Professor Christian Holscher, from Lancaster University, said these “very promising outcomes” show multi-action drugs developed for type 2 diabetes “consistently show neurological protective effects”.\n \n\n \n \n \n \n \n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n Independent academics said a reduction in nerve-cell-killing protein molecules was particularly interesting and this was likely to be another avenue in the search for an elusive drug to combat dementia.\n \n\n \n \n \n \n \n\n\n\n\n\n \n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n He has previously reported optimistic findings from an older diabetes drug, liraglutide, and clinical trials in humans are currently under way.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n This latest study, published in the journal Brain Research, looked at a “triple action” treatment that combine three different drugs for type 2 diabetes, acting on biological pathways that could also have an impact on dementia.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n \n \n\n\n\n\n\n \n \n \n \n \n \n \n\n \n \n \n Type 2 diabetes is a known risk factor for Alzhemier’s disease and impaired production of insulin – the hormone that people with diabetes don’t produce sufficiently to control their blood sugar – is linked to brain degeneration.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n The identification of this link had a twofold benefit, according to charities.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n It opened up new research and drug development opportunities, such as this study.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n But it also means that by making lifestyle changes, like eating healthily and exercising, patients can avoid developing type-2 diabetes and lower their risk of Alzheimer’s disease as well.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n There are currently half a million people living with Alzheimer’s disease in the UK and more than five million people with diabetes, both conditions pose a major cost to the NHS, and health systems worldwide.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n \n\n \n\n \n \n \n The treatment in this study combined; GLP-1, GIP and glucagon, which, like insulin protect against neurological deterioration, and tested them in mice with genetic mutations that cause Alzheimer’s disease.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n After two months of daily injections the mice were shown to significantly improve their performance in a maze designed to test memory.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n \n \n\n \n\n\n\n\n\n \n \n \n \n \n Treated mice also had lower levels of proteins which clump together and form plaques in the brains of people with Alzheimer’s disease, inhibiting nerve cells’ ability to communicate and causing them to die.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n The study also found these mice lost nerve cells to the disease at a slower rate and had lower levels of nerve inflammation.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n It concludes that the triple treatment “holds clear promise of being developed into a new treatment for chronic neurodegenerative disorders such as Alzheimer’s disease”.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n \n \n\n \n\n\n\n\n\n \n \n \n \n \n \n \nThe seven Alzheimer's risk factors\n\n\n\n\n \n\n\n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n\n\n \n\n \n \n \n The Alzheimer’s Society, a charity which part-funded the latest study research, said that after 15 years without a new drug for Alzheimer’s disease the promising results from these crossover treatments, which are already known to be safe for humans, are likely to bring earliest benefits.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n Professor Holscher added that further tests to compare its benefits against other potential treatments, and its effects in humans were needed.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n But Professor John Hardy, a professor of neuroscience, at University College London who was not involved in the trial, said the study was “a first step, at best” towards a Alzheimer’s drug for humans.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n \n \n\n \n\n\n\n\n\n \n \n \n \n \n “The results showing less amyloid deposition of amyloid in mice treated with glucagon receptor stimulating drugs is interesting,” he said.\n \n\n \n \n \n \n \n \n “However, it should be noted that several other drugs have shown positive results in mice models of Alzheimer’s disease and then failed in human trials.”\n \n\n \n \n \n \n \n \n Dr David Reynolds, chief scientific officer at Alzheimer’s Research UK, echoed this, but added: “There is a long road between studies that show an effect in animals and treatments in the hands of patients, and scientists will only be able to realise the potential of promising findings like these if we continue to invest in research.”"],["topImageUrl","https://static.independent.co.uk/s3fs-public/thumbnails/image/2015/04/14/21/web-alzheimers-2-alamy.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease"],["url","https://www.sciencedirect.com/science/article/pii/S0006899317304596"],["summary","AbstractType 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD). Previous studies have shown that the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) that have anti-diabetic properties show very promising effects in animal models of AD. Glucagon (Gcg) is a hormone and growth-factor, and the Gcg receptor is expressed in the brain. Here we test the effects of a triple receptor agonist (TA), which activates GIP-1, GIP and glucagon receptors at the same time. In the present study, the effects of the TA were evaluated in the APP/PS1 transgenic mouse model of AD. The TA was injected once-daily (10 nmol/kg i.p.) for two months. The results showed that treatment with TA significantly reversed the memory deficit in the APP/PS1 mice in a spatial water maze test. Moreover, the drug reduced levels of the mitochondrial pro-apoptotic signaling molecule BAX, increased the anti-apoptotic signaling molecule Bcl-2 and enhanced the levels of BDNF, a key growth factor that protects synaptic function. Levels of synaptophysin were enhanced, demonstrating protection from synaptic loss that is observed in AD. Neurogenesis in the dentate gyrus was furthermore enhanced as shown in the increase of doublecortin positive cells. Furthermore, TA treatment reduced the total amount of β-amyloid, reduced neuroinflammation (activated microglia and astrocytes), and oxidative stress in the cortex and hippocampus. Thus, these findings show that novel TAs are a promising lead for the design of future treatment strategies in AD.Previous Next KeywordsInflammationGrowth factorBDNFBrainInsulinNeurodegeneration1. IntroductionAlzheimer’s disease (AD), is a progressive neurodegenerative disease, characterized clinically by progressive memory loss, cognitive decline, and aberrant behavior [1]. Currently, there is no treatment can improve this condition. Epidemiological studies have shown that type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD) (Luchsinger et al., 2004, Ohara et al., 2011). The underlying mechanism is most likely that insulin signaling is impaired in the brains of AD patients (Moloney et al., 2010, Talbot et al., 2012). This motivated research in drugs that have shown good effects in treating diabetes to investigate if they could be helpful in treating AD as well. Previous studies have shown that the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) can play a neuroprotective role in the brain and show very promising effects in animal models of AD (Duffy and Holscher, 2013, Faivre and Holscher, 2013b, Li et al., 2010, McClean et al., 2011, McClean and Holscher, 2014). Glucagon (Gcg) is a hormone and growth-factor, and the Gcg receptor is expressed in the brain (Hoosein and Gurd, 1984, Mayo et al., 2003). Activation of the receptor can activate neuronal activity and cellular Ca2+ signaling and may have neuroprotective properties (Ayush et al., 2015). Here we test the effects of a triple receptor agonist (TA), which activates GIP-1, GIP and glucagon receptors at the same time. This novel drug has been developed as a potential treatment for diabetes (Finan et al., 2015). No studies have been published that test the neuroprotective effects of this novel drug. We therefore tested this promising TA in the APPSWE/PS1dE9 mouse model of AD. This mouse model recapitulates some of the hallmarks of AD, such as memory loss, synaptic loss, reduction of synaptic plasticity, reduction of neurogenesis in the dentate gyrus, chronic inflammation in the brain, and formation of amyloid plaques in the brain (Duffy and Holscher, 2013, Goto et al., 2008, Hamilton et al., 2011, Hamilton and Holscher, 2012, McClean et al., 2011). We tested the effects of TA in this transgenic mouse model and evaluated the neuroprotective effects. We analyzed memory formation, hippocampal neurogenesis, the expression levels of Brain Derived Neurotrophic Factor (BDNF) (Blurton-Jones et al., 2009), mitochondrial apoptosis signaling proteins, neuroinflammation and oxidative stress levels.2. Results2.1. TA-treatment improved the learning and memory impairment of APP/PS1 mice in the water mazeA two-way ANOVA found a significant difference between groups (p < 0.0001) and over time (p < 0.001). In the Morris water test, it was observed that the control mice, APP/PS1 mice and TA-treated APP/PS1 mice had a similar escape latency (P > 0.05). On day 5, the average escape distance in searching for the hidden platform in the APP/PS1 mice was significantly longer than that in the control mice (P < 0.05). Compared to the APP/PS1 group, the TA-treated APP/PS1 group’s average escape distance was decreased (P < 0.01). There was no difference in swimming speed among these three groups in training days (P > 0.05).Then on day 6, the platform was removed and the probe trail test was conducted. A one way ANOVA analysis showed an overall difference between groups. The APP/PS1 mice spent less time in the target quadrant (P < 0.01) and had fewer times passing through the original position of the hidden platform (P < 0.01), compared with control mice. In the TA-treated APP/PS1 group, the time spent in target quadrant (P < 0.05) and the frequencies to cross the platform significantly increased (P < 0.05), compared to the APP/PS1 group Fig. 1.Download high-res image (302KB)Download full-size imageFig. 1. The novel TA improved the learning ability of APP/PS1 mice in the spatial water maze task. (A) The escape latency and swimming speed in the training trails. (B) The percentage of time in target quadrant and crossing platform times in the probe trials. The circle indicates the position of the platform during acquisition (C) Representative swimming tracks of the probe trial. * = P < .05, ** = P < .01 compared to the control group, ## = P < .01, # = P < .05 compared to the APP/PS1 group; Two-way ANOVA with Bonferroni repeated measures post hoc tests.2.2. TA-treatment ameliorated amyloid plaques in the brains of APP/PS1 miceIn the immunohistochemical analysis, we analyzed the amount of amyloid plaques present in the brains of APP-PS1 mice. A one-way ANOVA found an overall difference on the amyloid deposits in the cortex (F = 31.10, P < 0.0001) and the hippocampus (F = 30.38, P < 0.0001) of mice between groups. The Aβ1-42 depositions in the cortex and hippocampus of the APP/PS1 mice were significantly higher than that in the control mice (P < 0.001), while TA-treatment group significantly decreased the deposition (P < 0.001) compared to the APP/PS1 group. N = 6 per group. See Fig. 2.Download high-res image (211KB)Download full-size imageFig. 2. TA treatment reduced amyloid deposits in the cortex and hippocampus of APP/PS1 mice. A, D: control group; B, E: APP/PS1 group; C, F: APP/PS1+TA group. Scale bar in image D: 100 μm. *** = P < .001 compared to the control group; ### = P < .001 compared to the APP/PS1 group. One-way ANOVA with Bonferroni repeated measures post hoc tests. N = 6 per group.2.3. TA-treatment reduced the chronic inflammation response in the cortex and hippocampus of the APP/PS1 miceIn the immunohistochemical analysis, an anti-GFAP antibody was used as an indication of activated astrocytes. A one-way ANOVA found an overall difference on the GFAP expression in the cortex (F = 77.03, P < 0.0001) and the hippocampus (F = 86.51, P < 0.0001) of mice between groups. The levels of GFAP in the cortex and hippocampus of the APP/PS1 mice were significantly higher than that in the control mice (P < 0.001), while TA-treatment group significantly decreased (P < 0.001) compared to the APP/PS1 group. N = 6 per group. See Fig. 3.Download high-res image (362KB)Download full-size imageFig. 3. TA-treatment reduced the number of GFAP positive cells in the cortex and hippocampus of APP/PS1 mice. A, D: control group; B, E: APP/PS1 group; C, F: APP/PS1+TA. Scale bar in image D: 50μm. A higher magnification image has been added to show stained astroglia. *** = P < .001 compared with the control group; ### = P < .001 compared with the APP/PS1 group. One-way ANOVA with Bonferroni repeated measures post hoc tests. N = 6 per group.In the immunohistochemical analysis, an anti-IBA1 antibody was used as an indication of microglia activation. A one-way ANOVA found an overall difference on the IBA-1 expression in the cortex (F = 28.71, P < 0.0001) and the hippocampus (F = 66.42, P < 0.0001) of mice between groups. The levels of IBA-1 in the cortex and hippocampus of the APP/PS1 mice were significantly higher than that in the control mice (P < 0.001), while TA-treatment group significantly decreased (P < 0.001, P < 0.01) compared to the APP/PS1 group. N = 6 per group. See Fig. 4.Download high-res image (347KB)Download full-size imageFig. 4. TA treatment reversed the increase of IBA-1 positive cells in the cortex and hippocampus of APP/PS1 mice. A, D: control group; B, E: APP/PS1 group; C, F: APP/PS1+TA group. Scale bar in image D: 100 μm. A higher magnification image has been added to show stained microglia. *** = P < .001 compared to the control group; ## = P < .01, ### = P < .001 compared to the APP/PS1 group. One-way ANOVA with Bonferroni repeated measures post hoc tests. N = 6 per group.2.4. TA-treatment suppressed oxidative stress in the cortex and hippocampus of APP /PS1 miceIn the immunohistochemical analysis, 4-HNE was measured as an indicator of lipid peroxidation. A one-way ANOVA found an overall difference on the 4-HNE expression in the cortex (F = 60.60, P < 0.0001) and the hippocampus (F = 35.22, P < 0.0001) of mice between groups. The expressions of 4-HNE in the cortex and hippocampus of the APP/PS1 mice were significantly higher than that in the control mice (P < 0.001), while TA-treatment group significantly decreased (P < 0.001) compared to the APP/PS1 group. N = 6 per group, see Fig. 5a.Download high-res image (397KB)Download full-size imageFig. 5. Oxidative stress was reduced by the TA. 5A. TA-treatment reduced the increase of 4-HNE levels in the cortex and hippocampus in APP/PS1 mice. A, D: control group; B, E: APP/PS1 group; C, F: APP/PS1+TA group. Scale bar in image D: 100 μm. *** = P < .001 compared with controls; ###=P < .001 compared to the APP/PS1 group. 5B. TA treatment reduced the increase of 8-OHdG levels in the cortex and hippocampus of APP/PS1 mice. A, D: control group; B, E: APP/PS1 group; C, F: APP/PS1+TA group. Scale bar in image D: 100 μm. *** = P < .001 compared to the control group; ## = P < .01, ### = P < .001 compared with the APP/PS1 group. One-way ANOVA with Bonferroni repeated measures ***post hoc tests. N = 6 per group.In the immunohistochemical analysis, 8-OHdG was measured as an indicator of DNA oxidation. A one-way ANOVN found an overall difference on the 8-OHdG expression in the cortex (F = 38.72, P < 0.0001) and the hippocampus (F = 56.60, P < 0.0001) of mice between groups. The expressions of 8-OHdG in the cortex and hippocampus of the APP/PS1 mice were significantly higher than that in the control mice (P < 0.001), while TA-treatment group significantly decreased (P < 0.01, P < 0.001) compared to the APP/PS1 group. N = 6 per group, see Fig. 5b.2.5. TA-treatment increased immature neurons in the dentate gyrus of APP/PS1 miceIn the immunohistochemical analysis, numbers of neurogenesis, assessed by doublecortin (DCX). A one-way ANOVN found an overall difference on the DCX positive cell in the dentate gyrus (F = 43.61, P < 0.0001) of mice between groups. The numbers of DCX were much reduced in the APP/PS1 mice (P < 0.001) compared to the control mice. While TA-treatment partially prevented the reduction (P < 0.001) compared to the APP/PS1 mice. N = 6 per group. See Fig. 6.Download high-res image (169KB)Download full-size imageFig. 6. TA-treatment enhanced neurogenesis and increased numbers of DCX positive cell numbers in the dentate gyrus of APP/PS1 mice. A: control group; B: APP/PS1 group; C: APP/PS1+TA group. Scale bar in image A: 100 μm. *** = P < .001 compared with the control group; ### = P < .001 compared with the APP/PS1 group. One-way ANOVA with Bonferroni repeated measures post hoc tests. N = 6 per group.2.6. TA-treatment reversed the decrease of BDNF levels in the hippocampus of APP/PS1 miceBDNF, a key neurotrophic factor in the brain, was detected by Western blot analysis. A one-way ANOVA found an overall difference between groups (F = 20.01, P < 0.001). The expression of BDNF in hippocampus was reduced in APP/PS1 group (P < 0.001) compared to the control group. TA-treatment reversed the decreased (P < 0.05) compared to the APP/PS1 group. N = 6 per group. See Fig. 7a.Download high-res image (304KB)Download full-size imageFig. 7. A) TA-treatment increased levels of BDNF in the hippocampus of APP/PS1 mice. *** = P < .001compared with the control group; # = P < .05 compared with the APP/PS1 group. N = 6 per group. B) TA-treatment increased levels of synaptophysin in the hippocampus of APP/PS1 mice. *** = P < .001 compared with the control group; ## = P < .01 compared with the APP/PS1 group. N = 6 per group. C) TA-treatment increased the ratio of BAX/Bcl-2 in the hippocampus of APP/PS1 mice. *** = P < .001 compared with the control group; ### = P < .001 compared with the APP/PS1 group. One-way ANOVA with Bonferroni repeated measures post hoc tests. N = 6 per group.2.7. TA-treatment reversed the reduction of synaptophysin levelsSynaptophysin (SYN), a synaptic markers, was detected by Western blot analysis. A one-way ANOVA found an overall difference between groups (F = 20.46, P < 0.001). The level of SYN in hippocampus was decreased in the APP/PS1 group (P < 0.001) compared to the control group. While TA-treatment prevent the reduction (P < 0.01) compared to the APP/PS1 group. N = 6 per group. See Fig. 7b.2.8. TA-treatment showed potential anti-apoptotic effects by decreasing the BAX/Bcl-2 ratio in APP/PS1 miceThe expression of apoptotic proteins, including Bcl-2 (that suppress apoptosis) and BAX (that promotes apoptosis), was detected by Western blot analysis. A one-way ANOVA found an overall difference between groups (F = 77.64, P < 0.001). The ratio of BAX/Bcl-2 in hippocampus was increased (P < 0.001) compared to the control group. While TA-treatment partly decreased the ratio of BAX/Bcl-2 (P < 0.001) compared to the APP/PS1 group. N = 6 per group. See Fig. 7c.3. DiscussionThe results demonstrate for the first time that the novel GLP-1/GIP/Gcg receptor agonist has clear neuroprotective effects in the APP/PS1 mouse model of AD. Memory formation in the spatial water maze task was improved by the drug, and the amyloid plaque load in the cortex and hippocampus was reduced. This result confirms our previous findings that single GLP-1 or GIP analogues can protect from memory loss in this mouse model of AD (Faivre and Holscher, 2013a, Faivre and Holscher, 2013b, McClean et al., 2011, McClean and Holscher, 2014). The chronic inflammation response as seen in the activation of microglia and astrocytes is much reduced by the novel TA, similar to single GLP-1 or GIP receptor agonists (Duffy and Holscher, 2013, Ji et al., 2016a, McClean et al., 2011). Levels of the peroxidized lipid 4-HNE that also acts as a pro-apoptotic signal in mitochondria have been reduced by the TA. 4-HNE is one of the markers of membrane lipid peroxidation induced by cytotoxic radicals such as OH. 4-HNE has cytotoxic, mutagenic and genotoxic properties and 4-HNE is reported to stimulate apoptosis via caspase 3 activation and by inducing mitochondrial damage as shown in cytochrome c release (Ji et al., 2001). The levels of the mitochondrial apoptosis signal BAX (Kim et al., 2005) were also reduced. Importantly, the anti-apoptotic signaling molecule B-cell lymphoma 2 (Bcl-2) which is active in functioning mitochondria that have normal inner membrane voltage potentials (Kavitha et al., 2013) is upregulated by the TA, adding to the neuroprotective effect. The level of chronic oxidative stress as measure by the levels of the oxidized nucleotide 8-Hydroxiguanosine (8-OHdG) was also reduced by the drug. Neurogenesis in the dentate gyrus was normalized. Importantly, the levels of the key growth factor BDNF were normalized in the brain. BDNF has shown clear neuroprotective effects in a range of animal models of disease (Allen et al., 2013, Benedetti et al., 2014, Blurton-Jones et al., 2009, Nagahara et al., 2013). An important factor of BNDF activity is that it maintains synaptic activity and protects synapses from stressors (Kuipers and Bramham, 2006). The observation that the synaptic marker synaptophysin was expressed at normal levels after TA treatment also indicates that synaptic numbers and function was improved in the AD mouse. We have shown previously that GLP-1 and GIP analogues protect synapses from amyloid induced stress and keeps them functional (Faivre and Holscher, 2013b, Gault and Holscher, 2008a, Gault and Holscher, 2008b, McClean and Holscher, 2014).Recently, multiple receptor agonists have been developed to treat type II diabetes (Finan et al., 2013, Finan et al., 2015). We have tested novel dual GLP-1/GIP receptor agonists that showed good neuroprotective effects that are superior to single GLP-1 analogues (Cao et al., 2016, Jalewa et al., 2017, Ji et al., 2016b, Yuan et al., 2017). The novel dual agonist DA3-CH was found to be superior to liraglutide in a mouse model of Parkinson’s disease (Yuan et al., 2017), demonstrating that the strategy of activating more than one incretin receptor type offers an advantage over single receptor agonists. Here, we show that a novel triple receptor agonist also shows promise as a potential treatment for AD, but further dose–response tests and direct comparisons with other drugs have to be conducted in order to evaluate if this new drug is superior to previous ones.GLP-1, GIP and glucagon are members of the growth factor family (Hölscher, 2016). Their respective receptors are classic 7-membrane spanning domain, G-protein coupled receptors that activate cAMP synthesis (Campbell and Drucker, 2013, Doyle and Egan, 2007, Holst et al., 2011). The activation of the second messenger cascade cAMP-PKA-CREB induces a number of cytoprotective processes, including the normalization of energy utilization, cell repair and growth-factor related gene expression (Holscher, 2014, Jalewa et al., 2016, Perry and Greig, 2004, Sharma et al., 2013). Importantly, GLP-1 and GIP also have anti-inflammatory properties. Astroglia and microglia express the receptors, and activating these reduce the inflammation response (Duffy and Holscher, 2013, Jalewa et al., 2017, Parthsarathy and Holscher, 2013, Spielman et al., 2017). Chronic inflammation is a main driver of neurodegenerative disorders, and a reduction of the inflammation in the brain shows protective effects (Akiyama et al., 2000, Clark et al., 2012, Lee et al., 2010).Based on the impressive preclinical data that demonstrate neuroprotection of such drugs, clinical trials have started that investigate the neuroprotective effects of the GLP-1 receptor agonists exendin-4 (Byetta, Bydureon®) and liraglutide (Victoza®) in patients with AD or with Parkinson disease (PD). A pilot study testing the GLP-1 analogue liraglutide in AD patients showed promising results. In a double blind, placebo controlled trial, AD patients showed no deterioration in brain activity as measured in the 18FDG-PET scan after 12 months of drug treatment. In contrast, the placebo group showed clear reductions in cortical activity as expected for this progressive neurodegenerative disease (Gejl et al., 2016). A phase II clinical trial is currently ongoing (Hölscher, 2016). A pilot trial testing exendin-4 in PD patients has shown good effects (NCT01174810). This open-label study tested the effects of exendin-4 in 45 patients. There were clear improvements in the motor coordination as shown in the MDS-UPDRS part 3 assessment, and cognition was improved as measured by the Mattis DRS-2 test battery that had been designed to evaluate cognitive impairments in PD patients (Aviles-Olmos et al., 2013). Patients were re-tested 12 months later, and the differences in motor performance and cognitive scores were still visible (Aviles-Olmos et al., 2014). A phase II double-blind, placebo controlled clinical trial that tested the once-weekly formulation of exendin-4, Bydureon®, confirmed the results of the pilot study. The drug group did not deteriorate in the MDS-UPDRS part 3 assessment after 48 weeks of treatment, and after 12 weeks of a wash-out period, the disease-modifying effect was still visible. In contrast, the placebo group deteriorated over time as would be expected in this disease (Athauda et al., 2017). In addition, a phase II trial testing liraglutide in PD patients has started, testing patients in a double blind, placebo controlled trial for one year (NCT02953665). A further clinical trial testing the GLP-1 receptor agonist Lixisenatide in PD patients is in planning.These very promising preclinical and the first clinical outcomes demonstrate the efficacy of these novel multiple receptor agonists that originally were developed to treat type II diabetes, but have shown consistent neuroprotective effects in several studies. In the present study, the novel TA improved learning and memory, reduce amyloid plaque load, chronic inflammation and oxidative stress, as well as mitochondrial stress signaling, and improved BDNF release and synaptic markers while normalising neurogenesis in the dentate gyrus. The novel triple GLP-1/GIP/Gcg receptor agonist holds clear promise of being developed into a new treatment for chronic neurodegenerative disorders such as Alzheimer’s disease.4. Materials and methods4.1. Peptide and chemicalsThe triple GLP-1/GIP/Gcg used in this study was synthesized by China Peptides Co, Ltd. (Shanghai, China) to 95% purity. The identity and purity of the peptide was confirmed by reversed-phase HPLC and characterized using matrix assisted laser resorption/ionization time of flight (MALDI–TOF) mass spectrometry. The peptide was stored in dry form and dissolved in double-distilled water containing 0.9% NaCl2 before experiments. A Bi-cinchoninicacid (BCA) protein assay kit was purchased from Apply gen Technologies Inc. (Beijing, China). 3, 3-diaminobenzidine (DAB) was purchased from ZSGB-BIO Co. (Beijing, China). The primary antibodies recognizing Aβ1-42, IBA-1, BDNF, 4-Hydroxynonenal (4-HNE), 8-Hydroxyguanosine (8-OHdG), synaptophysin (SYN) and β-actin were obtained from Abcam (Cambridge, UK). The primary antibody GFAP, Bcl-2, and BAX were obtained from Boster Biotechnology (Wuhan, China). The primary antibody doublecortin (DCX) buy from Santa Cruz Biotechnology. HRP-labeled goat anti-rabbit immunoglobulin was obtained from Abcam (Cambridge, UK). The biotinylated goat anti-rabbit IgG, biotinylated rabbit anti-goat IgG, avidinbiotin peroxidase complex reagent was purchased from Boster Biotechnology (Wuhan, China). All other reagents used in the research were of analytical grade and of the highest quality commercially available. The peptide sequence was as follows (Finan et al., 2015):HXQGTFTSDKSKYLDERAAQDFVQWLLDGGPSSGAPPPSX = aminoisobutyric acid, K = γE-C16 acylation (with a C16 fatty acid).4.2. Animals and treatmentsAPP/PS1 transgenic mice were purchased from the Academy of Military Medical Sciences (AMMS, China), were maintained in a constant temperature (22 ± 1 °C) and humidity (relative 30%) under a 12 h light/dark cycle in animal house. As well as age-matched non-AD mice, which are wild-type animals as control. When animals were 6 months of age, TA was dissolved in saline. The dose was a once-daily injection of 10 nmol/kg body weight ip. for two months. Injections were given in the morning (8:00 am). Control mice received equal volumes of saline solution. All experimental procedures involving animals were approved by the Institutional Animal Care Committee of Shanxi Medical University and conform to the guidelines of National Institute of Health (NIH) guideline (NIH publication No. 85-23. Revised 1985). They were divided into three different groups (n = 12). (i): control group treated with saline only; (ii): APP/PS1 group treated with saline only; (iii): APP/PS1 group treated with TA. At the end of drug treatments, measurements of behavioral change, neuronal damage, oxidative stress and inflammatory markers were conducted.4.3. Morris water maze testThe water maze test is a standard method for assessing learning and memory in animals. The water maze (WM) task was performed 5 days after two months intraperitoneal injection. The apparatus was a circular, white painted pool (150 cm in diameter and 60 cm in height) which was filled to a depth of 40 cm with warm water at a temperature 23 ± 2 °C to avoid hypothermia, and was surrounded by a white curtain around the pool. The pool was divided into four quadrants with four starting locations, north (N), east (E), south (S) and west (W), the starting quadrant was randomly chosen. A perspex platform (diameter, 10 cm) was located in a specific location during the acquisition trials and submerged approximately 1.0 cm below the surface of the water. A video camera was mounted directly above the pool to record the movement and the trail of the mice. During the acquisition phase, each mouse was subjected to four consecutive training trials on each day. The mouse was gently placed in the water between the quadrants, and allowed 60 s to search the hidden platform. If it failed to find the platform within 60 s, it was guided to the platform and allowed to remain there for 10 s. Training continued for 5 days. On the sixth day, the hidden platform was removed and each mouse was allowed to swim in the pool for 60 s. The mean time spent in all four quadrants and the target area for searching the hidden platform was recorded.4.4. Brain tissue preparationHalf of the animals were decapitated after anesthetization with ethyl carbamate, hippocampus tissues were immediately isolated and stored at −80 °C for further investigations. The second half of each group was used for immunohistochemistry analysis. Animals were perfused intracardially with saline and cold 4% paraformaldehyde. Brains were removed and post-fixed in 4% paraformaldehyde for 24 h.4.5. ImmunohistochemistryFor DAB staining, fixed tissues were embedded in paraffin. Coronal sections (5 μm thick) of the brains were cut on a Leica microtome for immunohistochemistry. Paraffin was removed from the tissue sections with xylene, and the sections were rehydrated in graded ethanol solutions. Endogenous peroxidase activity was blocked with 3% H2O2 for 10 min at room temperature. Antigen retrieval was performed by heating in 10 mmol/L citrate buffer (pH 6.0) for 10 min. After blocked with 5% BSA, sections were incubated with the primary antibody for doublecortin (goat anti-DCX; 1:50), GFAP (rabbit anti-GFAP; 1:100), IBA-1 (goat anti-IBA1; 1:200), 4-Hydroxynonenal antibody (goat anti-4 HNE; 1:200) and anti-8 Hydroxyguanosine antibody (goat anti-8 OHdG; 1:200) at 37 °C for 2 h. For the Anti-8 OHdG histology, enzymatic antigen retrieval with 10 μm/ml proteinase K for 40 min at 37 °C was performed. To detect amyloid deposits, the primary antibody was Aβ1-42 (rabbit anti-Aβ1-42; 1:100), brain sections were pre-incubated with 70% formic acid and incubated at 4 °C for 24 h. They were rinsed in PBS and incubated with biotinylated goat anti-rabbit IgG or biotinylated rabbit anti-goat IgG at 37 °C for 0.5 h and incubated with the avidin-biotin peroxidase complex reagent at 37 °C for 0.5 h. Samples were stained in DAB solution in the presence of H2O2. All stained sections were viewed and photographed under a Zeiss light microscope, and images were captured by Motic Images Plus2.0ML software. The numbers of DCX positive neurons, the areas of Aβ1-42, GFAP, IBA-1, 4-HNE and 8-OHdG positive cells were determined using Image-pro plus6.0 software. The software counts objects that are defined in size and staining threshold by the user. This automated process avoided user bias.4.6. Western blotThe hippocampal tissues from mice was homogenized in ice cold RIPA buffer (containing 1% Triton X-100, 0.1% SDS, 1% deoxycholate) and PMSF (phenyl-methylsulfonyl fluoride). The homogenate was centrifuged 12,000 rpm/min for 5 min at 4 °C before taking the supernatant. Tissue containing 60 μg of protein was separated on 10–12% gradient Bis–Tris gel with molecular marker and electrophoresed in running buffer at 120 mV for 90 min followed by transfer to the PVDF membrane. Following protein transfer, the membrane was washed in TBST (tris buffered saline with 0.05% Tween-20, pH 8) and blocked in 5% skim milk for 1 h. Then incubated overnight at 4 °C with rabbit anti-synaptophysin (SYN) (1:10,000), rabbit anti-Bcl-2 (1:400), rabbit anti-BAX (1:400), rabbit anti-BDNF (1:5000), after three washes in TBS further incubation for 2 h at room temperature with the HRP-labeled goat anti-rabbit immunoglobulin (1:5000). In some cases, the blots were stripped and reprobed with a rabbit anti-β-actin (1:5000) to ensure equal sample loading. The bound antibodies were then visualized by ECL-enhanced chemiluminescence (Beyotime Institute of Biotechnology, Shanghai, China) according to the manufacturer's instructions. Western blot images were captured with a chemiluminescent imaging system (Sage Creation, Beijing, China). All bands were quantified using the image system of Alpha View SA.4.7. Statistical analysisThe data were presented as the mean ± standard error of mean (S.E.M.) and analyzed by one-way or two way ANOVA followed by Bonferroni’s multiple comparison test using the software Prism 5 (Graph Pad Software Inc, La Jolla, CA, USA). Statistical significance is defined as P < 0.05.ContributorsJT, WL and YL conducted the experiments, LL and CH conceived the experiment and wrote the manuscript.AcknowledgementsThis work was funded by the Ministry of Human Resources and Social Security, Shanxi Province [(2010)255], by a Shanxi Scholarship Council of China, and supported by a grant from the Alzheimer Society UK. The authors declare no conflict of interestAppendix A. Supplementary dataReferencesAkiyama et al., 2000H. Akiyama, S. Barger, S. Barnum, B. Bradt, J. Bauer, G.M. Cole, N.R. Cooper, P. Eikelenboom, M. Emmerling, B.L. Fiebich, C.E. Finch, S. Frautschy, W.S. Griffin, H. Hampel, M. Hull, G. Landreth, L. Lue, R. Mrak, I.R. Mackenzie, P.L. McGeer, M.K. O'Banion, J. Pachter, G. Pasinetti, C. Plata-Salaman, J. Rogers, R. Rydel, Y. Shen, W. Streit, R. Strohmeyer, I. Tooyoma, F.L. Van Muiswinkel, R. Veerhuis, D. Walker, S. Webster, B. Wegrzyniak, G. Wenk, T. Wyss-CorayInflammation and Alzheimer’s diseaseNeurobiol. Aging, 21 (2000), pp. 383-421Allen et al., 2013S.J. Allen, J.J. Watson, D.K. Shoemark, N.U. Barua, N.K. PatelGDNF, NGF and BDNF as therapeutic options for neurodegenerationPharmacol. Ther., 138 (2013), pp. 155-175Athauda et al., 2017D. Athauda, K. Maclagan, S.S. Skene, M. Bajwa-Joseph, D. Letchford, K. Chowdhury, S. Hibbert, N. Budnik, L. Zampedri, J. Dickson, Y. Li, I. Aviles-Olmos, T.T. Warner, P. Limousin, A.J. Lees, N.H. Greig, S. Tebbs, T. FoltynieExenatide once weekly versus placebo in Parkinson’s disease: a randomised, double-blind, placebo-controlled trialAviles-Olmos et al., 2013I. Aviles-Olmos, J. Dickson, Z. Kefalopoulou, A. Djamshidian, P. Ell, T. Soderlund, P. Whitton, R. Wyse, T. Isaacs, A. Lees, P. Limousin, T. FoltynieExenatide and the treatment of patients with Parkinson’s diseaseJ. Clin. Invest., 123 (2013), pp. 2730-2736Aviles-Olmos et al., 2014I. Aviles-Olmos, J. Dickson, Z. Kefalopoulou, A. Djamshidian, J. Kahan, P.E. Fmedsci, P. Whitton, R. Wyse, T. Isaacs, A. Lees, P. Limousin, T. FoltynieMotor and cognitive advantages persist 12 months after exenatide exposure in Parkinson’s diseaseJ. Parkinson’s Dis., 4 (2014), pp. 337-344Ayush et al., 2015E.A. Ayush, Y. Iwasaki, S. Iwamoto, H. Nakabayashi, M. Kakei, T. YadaGlucagon directly interacts with vagal afferent nodose ganglion neurons to induce Ca(2+) signaling via glucagon receptorsBiochem. Biophys. Res. Commun., 456 (2015), pp. 727-732Benedetti et al., 2014E. Benedetti, B. D'Angelo, L. Cristiano, E. Di Giacomo, F. Fanelli, S. Moreno, F. Cecconi, A. Fidoamore, A. Antonosante, R. Falcone, R. Ippoliti, A. Giordano, A. CiminiInvolvement of peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) in BDNF signaling during aging and in Alzheimer disease: possible role of 4-hydroxynonenal (4-HNE)Cell Cycle, 13 (2014), pp. 1335-1344Blurton-Jones et al., 2009M. Blurton-Jones, M. Kitazawa, H. Martinez-Coria, N.A. Castello, F.J. Muller, J.F. Loring, T.R. Yamasaki, W.W. Poon, K.N. Green, F.M. LaferlaNeural stem cells improve cognition via BDNF in a transgenic model of Alzheimer diseaseProc. Natl. Acad. Sci. U.S.A., 106 (2009), pp. 13594-13599Campbell and Drucker, 2013J.E. Campbell, D.J. DruckerPharmacology, physiology, and mechanisms of incretin hormone actionCell Metab., 17 (2013), pp. 819-837Cao et al., 2016L. Cao, D. Li, P. Feng, L. Li, G. Xue, G. Li, C. HölscherA novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brainNeuroreport, 37 (2016), pp. 384-391Clark et al., 2012I. Clark, C. Atwood, R. Bowen, G. Paz-Filho, B. VisselTumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationalesPharmacol. Rev., 64 (2012), pp. 1004-1026Doyle and Egan, 2007M.E. Doyle, J.M. EganMechanisms of action of glucagon-like peptide 1 in the pancreasPharmacol. Ther., 113 (2007), pp. 546-593Duffy and Holscher, 2013A.M. Duffy, C. HolscherThe incretin analogue D-Ala(2)GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer’s diseaseNeuroscience, 228 (2013), pp. 294-300Faivre and Holscher, 2013aE. Faivre, C. HolscherD-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer's disease mouse modelJ. Alzheimers Dis., 35 (2013), pp. 267-283Faivre and Holscher, 2013bE. Faivre, C. HolscherNeuroprotective effects of D-Ala2GIP on Alzheimer’s disease biomarkers in an APP/PS1 mouse modelAlzheimers Res. Ther., 5 (2013), pp. 20-28Finan et al., 2013B. Finan, T. Ma, N. Ottaway, T.D. Muller, K.M. Habegger, K.M. Heppner, H. Kirchner, J. Holland, J. Hembree, C. Raver, S.H. Lockie, D.L. Smiley, V. Gelfanov, B. Yang, S. Hofmann, D. Bruemmer, D.J. Drucker, P.T. Pfluger, D. Perez-Tilve, J. Gidda, L. Vignati, L. Zhang, J.B. Hauptman, M. Lau, M. Brecheisen, S. Uhles, W. Riboulet, E. Hainaut, E. Sebokova, K. Conde-Knape, A. Konkar, R.D. DiMarchi, M.H. TschopUnimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humansSci. Transl. Med., 5 (2013), p. 209ra151Finan et al., 2015B. Finan, B. Yang, N. Ottaway, D.L. Smiley, T. Ma, C. Clemmensen, J. Chabenne, L. Zhang, K.M. Habegger, K. Fischer, J.E. Campbell, D. Sandoval, R.J. Seeley, K. Bleicher, S. Uhles, W. Riboulet, J. Funk, C. Hertel, S. Belli, E. Sebokova, K. Conde-Knape, A. Konkar, D.J. Drucker, V. Gelfanov, P.T. Pfluger, T.D. Muller, D. Perez-Tilve, R.D. DiMarchi, M.H. TschopA rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodentsNat. Med., 21 (2015), pp. 27-36Gault and Holscher, 2008aV.A. Gault, C. HolscherGLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloidEur. J. Pharmacol., 587 (2008), pp. 112-117Gault and Holscher, 2008bV.A. Gault, C. HolscherProtease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloidJ. Neurophysiol., 99 (2008), pp. 1590-1595Gejl et al., 2016M. Gejl, A. Gjedde, L. Egefjord, A. Møller, S.B. Hansen, K. Vang, A.B. Rodell, H. Braendgaard, H. Gottrup, A. Schacht, N. Møller, B. Brock, J. RungbyIn Alzheimer’s disease, six-month treatment with glp-1 analogue prevents decline of brain glucose metabolism: randomized, placebo-controlled double-blind clinical trialFront. Aging Neurosci., 8 (2016), pp. 1-10Goto et al., 2008Y. Goto, T. Niidome, H. Hongo, A. Akaike, T. Kihara, H. SugimotoImpaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's diseaseEur. J. Pharmacol., 583 (2008), pp. 84-91Hamilton et al., 2011A. Hamilton, S. Patterson, D. Porter, V.A. Gault, C. HolscherNovel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brainJ. Neurosci. Res., 89 (2011), pp. 481-489Hamilton and Holscher, 2012A. Hamilton, C. HolscherThe effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's diseaseBrain Res., 1449 (2012), pp. 83-93Holscher, 2014C. HolscherInsulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseasesBiochem. Soc. Trans., 42 (2014), pp. 593-599Hölscher, 2016C. HölscherGLP-1 and GIP analogues as novel treatments for Alzheimer’s and Parkinson’s diseaseCardiovasc. Endocrinol., 5 (2016), pp. 93-98Holst et al., 2011J.J. Holst, R. Burcelin, E. NathansonNeuroprotective properties of GLP-1: theoretical and practical applicationsCurr. Med. Res. Opin., 27 (2011), pp. 547-558Hoosein and Gurd, 1984N.M. Hoosein, R.S. GurdIdentification of glucagon receptors in rat brainProc. Natl. Acad. Sci. U.S.A., 81 (1984), pp. 4368-4372Jalewa et al., 2016J. Jalewa, M.K. Sharma, C. HolscherNovel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cellsJ. Neurochem., 139 (2016), pp. 55-67Jalewa et al., 2017J. Jalewa, M. Sharma, S. Gengler, C. HölscherA novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson’s diseaseNeuropharmacology, 117 (2017), pp. 238-248Ji et al., 2001C. Ji, V. Amarnath, J.A. Pietenpol, L.J. Marnett4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c releaseChem. Res. Toxicol., 14 (2001), pp. 1090-1096Ji et al., 2016aC. Ji, G.F. Xue, G. Li, D. Li, C. HolscherNeuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's diseaseRev. Neurosci., 27 (2016), pp. 61-70Ji et al., 2016bC. Ji, G.F. Xue, C. Lijun, P. Feng, D. Li, L. Li, G. Li, C. HolscherA novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDFBrain Res., 1634 (2016), pp. 1-11Kavitha et al., 2013M. Kavitha, J. Nataraj, M.M. Essa, M.A. Memon, T. ManivasagamMangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson's disease miceChem. Biol. Interact., 206 (2013), pp. 239-247Kim et al., 2005S.J. Kim, K. Winter, C. Nian, M. Tsuneoka, Y. Koda, C.H. McIntoshGlucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expressionJ. Biol. Chem., 280 (2005), pp. 22297-22307Kuipers and Bramham, 2006S.D. Kuipers, C.R. BramhamBrain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapyCurr. Opin. Drug Discov. Dev., 9 (2006), pp. 580-586Lee et al., 2010Y.J. Lee, S.B. Han, S.Y. Nam, K.W. Oh, J.T. HongInflammation and Alzheimer's diseaseArch. Pharm. Res., 33 (2010), pp. 1539-1556Li et al., 2010Y. Li, K. Duffy, M. Ottinger, B. Ray, J. Bailey, H. Holloway, D. Tweedie, T. Perry, M. Mattson, D. Kapogiannis, K. Sambamurti, D. Lahiri, N. GreigGLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's diseaseJ. Alzheimers Dis., 19 (2010), pp. 1205-1219Luchsinger et al., 2004J.A. Luchsinger, M.X. Tang, S. Shea, R. MayeuxHyperinsulinemia and risk of Alzheimer diseaseNeurology, 63 (2004), pp. 1187-1192Mayo et al., 2003K.E. Mayo, L.J. Miller, D. Bataille, S. Dalle, B. Goke, B. Thorens, D.J. DruckerInternational Union of Pharmacology. XXXV. The glucagon receptor familyPharmacol. Rev., 55 (2003), pp. 167-194McClean et al., 2011P. McClean, V. Parthsarathy, E. Faivre, C. HölscherThe diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's diseaseJ. Neurosci., 31 (2011), pp. 6587-6594McClean and Holscher, 2014P.L. McClean, C. HolscherLixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's diseaseNeuropharmacology, 86C (2014), pp. 241-258Moloney et al., 2010A.M. Moloney, R.J. Griffin, S. Timmons, R. O'Connor, R. Ravid, C. O'NeillDefects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signallingNeurobiol. Aging, 31 (2010), pp. 224-243Nagahara et al., 2013A.H. Nagahara, M. Mateling, I. Kovacs, L. Wang, S. Eggert, E. Rockenstein, E.H. Koo, E. Masliah, M.H. TuszynskiEarly BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic miceJ. Neurosci., 33 (2013), pp. 15596-15602Ohara et al., 2011T. Ohara, Y. Doi, T. Ninomiya, Y. Hirakawa, J. Hata, T. Iwaki, S. Kanba, Y. KiyoharaGlucose tolerance status and risk of dementia in the community: the Hisayama studyNeurology, 77 (2011), pp. 1126-1134Parthsarathy and Holscher, 2013V. Parthsarathy, C. HolscherThe type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brainEur. J. Pharmacol., 700 (2013), pp. 42-50Perry and Greig, 2004T.A. Perry, N.H. GreigA new Alzheimer's disease interventive strategy: GLP-1Curr. Drug Targets, 5 (2004), pp. 565-571Sharma et al., 2013M. Sharma, J. Jalewa, C. HolscherNeuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to Methylglyoxal stressJ. Neurochem., 128 (2013), pp. 459-471Spielman et al., 2017L.J. Spielman, D.L. Gibson, A. KlegerisIncretin hormones regulate microglia oxidative stress, survival and expression of trophic factorsEur. J. Cell Biol., 96 (2017), pp. 240-253Talbot et al., 2012K. Talbot, H.Y. Wang, H. Kazi, L.Y. Han, K.P. Bakshi, A. Stucky, R.L. Fuino, K.R. Kawaguchi, A.J. Samoyedny, R.S. Wilson, Z. Arvanitakis, J.A. Schneider, B.A. Wolf, D.A. Bennett, J.Q. Trojanowski, S.E. ArnoldDemonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive declineJ. Clin. Invest., 122 (2012), pp. 1316-1338Yuan et al., 2017Z. Yuan, L. Li, P. Feng, G. Xue, C. Ji, G. Li, C. HölscherA novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson’s disease© 2017 Elsevier B.V. All rights reserved."],["topImageUrl","https://ars.els-cdn.com/content/image/1-s2.0-S0006899317X0022X-cov150h.gif"],["error",null]]}]}],["text","阿茲海默症(Alzheimer’s disease)疾病對於病人及家屬皆會帶來很大的影響，然而至目前為止，疾病的發生機轉及可能的治療方式卻仍在研究階段。《Cell Reports》日前刊登中國山西醫科大學(Shanxi Medical University)的最新發表，研究團隊表示，原先發展用來治療糖尿病的特定藥物，有機會反轉阿茲海默症的記憶喪失症狀。第二型糖尿病已知為阿茲海默症的風險因子之一，其病程會影響到胰島素的分泌，而在過去的研究中亦曾發現，這個影響人體血糖調節的荷爾蒙，其分泌不足可能與大腦的退化情形有關。本篇研究中，作者發現結合第二型糖尿病的特定藥物，可能改善數項阿茲海默症的獨特病徵。作者表示，這項研究發現，有助於未來發展阿茲海默症及其它神經退化疾病的新治療方法。\n \n新聞出處：Alzheimer's treatment: Diabetes drug holds promise for fighting disease after 'significantly reversing' memory loss《Independent》\nhttp://www.independent.co.uk/news/health/alzheimers-diabetes-drug-memory-loss-reverse-disease-treatment-degenerative-a8133681.html\n研究刊登在《Cell Reports》第1678卷第64-74頁\nhttps://www.sciencedirect.com/science/article/pii/S0006899317304596\n "],["id","AWEET-BFyCdS-nWhunGr"],["createdAt","2018-01-17T13:29:59.107Z"]]}]}],["relatedReplies",{"__iterable":"List","data":[{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",4],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_xKGo3g-HTVqTBBpOjChzkhT4lx_Fry5Dd_aZvLNrEUk"],["name","可靠的楠西桃樂斯"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","ACE王牌數位貨幣交易"],["url","https://www.ace.io/activity/invite-register?invite_code=00025776"],["summary","Copyright © 2018-2019 Ace Digital Innovations Co., Ltd. 王牌數位創新股份有限公司 All Rights Reserved."],["topImageUrl","https://www.ace.io/dda5fd010bfa0160e8edbd6dc90212e6.png"],["error",null]]}]}],["text","台灣唯一完全合法落地交易所，更榮獲經濟部核准補助，嚴守KYC.AML規格，ABA x ACE x ABF=ABE虛擬貨幣實體交易所，打造台灣最大最完整區塊鏈技術，並提供法規.財稅.技術.產品.業務.行銷全方面輔導。\n\n現在註冊ACE完成實名B級認證\n就送超多獎勵回饋金！\n\n盡快把握時間參與活動，並且將此消息分享給親朋好友吧！\n\n註冊邀請碼\nhttps://www.ace.io/activity/invite-register?invite_code=00025776\n心存善念，絕不詐騙"],["id","2y4yg1kklj78c"],["createdAt","2019-12-07T03:10:06.555Z"]]}],["reply",{"__iterable":"Map","data":[["id","RCkf_ogBFLWd9xY2aBDd"],["user",{"__iterable":"Map","data":[["id","KWuSw4gBvEj1WkaU2x-j"],["name","Kobe"],["avatarUrl",null],["level",9]]}],["type","RUMOR"],["text","其實目前完成 B 級認證只能獲得 1 USDT 的獎勵，並不是很多。另外，ACE 至今 2023 年也算是成立相對較久的台灣加密貨幣交易所，目前還算相對可靠，CoinMarketCap 上可以查到 ACE 交易所的資料，而我自己使用上也沒有太大問題。"],["reference","https://ace.io/\nhttps://coinmarketcap.com/zh-tw/rankings/exchanges/\nhttps://digitalyoming.com/ace-exchange-introduction/"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","ACE 王牌虛擬貨幣交易所 | 台灣首家合法合規虛擬貨幣交易所 | 比特幣買賣"],["url","https://ace.io/"],["summary","ACE 王牌虛擬貨幣交易所提供新台幣購買虛擬貨幣，例如比特幣（BTC）、以太幣（ETH）、USDT（泰達幣）等主流幣種，24小時隨時可以買賣，加上凱基銀行新台幣價金信託，安全有保障"],["topImageUrl",null],["error",null]]},{"__iterable":"Map","data":[["title","根據交易量排名領先之加密貨幣交易所 | CoinMarketCap"],["url","https://coinmarketcap.com/zh-tw/rankings/exchanges/"],["summary","查看我們的加密貨幣交易所列表 ✔️ 按交易量排名 ✔️ 幣安 ✔️ Coinbase Pro ✔️ 火幣 ✔️ Kraken ✔️ Bithumb ✔️ Bitfinex ✔️ 還有更多 ✔️"],["topImageUrl",null],["error",null]]},{"__iterable":"Map","data":[["title","ACE 交易所安全嗎？是詐騙嗎？PTT/Dcard 評價如何？手續費多少？"],["url","https://digitalyoming.com/ace-exchange-introduction/"],["summary","在台灣如果要投資加密貨幣，通常都會註冊幾間台灣的虛擬貨幣交易所來用，而 ACE 交易所就是其中之一。因此這篇文章會介紹 ACE 相關的背景、評價跟功能性，究竟這個平台安不安全？合不合法？提供了什麼樣的服務？PTT 跟 Dcard 的網友又有什麼樣的看法？"],["topImageUrl",null],["error",null]]}]}],["createdAt","2023-06-27T18:30:51.367Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",4],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_xKGo3g-HTVqTBBpOjChzkhT4lx_Fry5Dd_aZvLNrEUk"],["name","可靠的楠西桃樂斯"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","ACE王牌數位貨幣交易"],["url","https://www.ace.io/activity/invite-register?invite_code=00025776"],["summary","Copyright © 2018-2019 Ace Digital Innovations Co., Ltd. 王牌數位創新股份有限公司 All Rights Reserved."],["topImageUrl","https://www.ace.io/dda5fd010bfa0160e8edbd6dc90212e6.png"],["error",null]]}]}],["text","台灣唯一完全合法落地交易所，更榮獲經濟部核准補助，嚴守KYC.AML規格，ABA x ACE x ABF=ABE虛擬貨幣實體交易所，打造台灣最大最完整區塊鏈技術，並提供法規.財稅.技術.產品.業務.行銷全方面輔導。\n\n現在註冊ACE完成實名B級認證\n就送超多獎勵回饋金！\n\n盡快把握時間參與活動，並且將此消息分享給親朋好友吧！\n\n註冊邀請碼\nhttps://www.ace.io/activity/invite-register?invite_code=00025776\n心存善念，絕不詐騙"],["id","2y4yg1kklj78c"],["createdAt","2019-12-07T03:10:06.555Z"]]}],["reply",{"__iterable":"Map","data":[["id","FlYJ-24BV0DITCqGsGWj"],["user",{"__iterable":"Map","data":[["id","AVy59B4MyCdS-nWhuapS"],["name","Lucien Lee"],["avatarUrl","https://www.gravatar.com/avatar/166c6d89712db394acce65039c2cfe00?s=100&d=identicon&r=g"],["level",11]]}],["type","RUMOR"],["text","ACE 交易所不是台灣唯一合法加密貨幣交易所，事實上2019年台灣相關法規細則也還未定案，並沒有合法違法之說。\n"],["reference","https://www.blocktempo.com/taiwan-fsc-moj-regulators-aml/"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","台灣加強虛擬貨幣監管：反洗錢納管下半年開跑；三種特許業務須向金管會申請"],["url","https://www.blocktempo.com/taiwan-fsc-moj-regulators-aml/"],["summary","台灣金融監管機構正準備執行虛擬貨幣業務的進一步納管，暫定以台灣兩大自律組織為管理對象，在反洗錢子法敲定後，電子支付、匯款及 STO（證券型代幣發行）三種特許業務都必須向金管會申請，或進入沙盒實驗。\n\n由於全球虛擬貨幣交易所盛行，為配合亞太防制洗錢組織（APG）與國際防制洗錢金融小組（FATF）的最新動作，金管會、法務部也嚴密備戰，以防堵洗錢漏洞，反洗錢納管預計在下半年預告相關子法後即會正式上路。\n>>G20 成員國達成共識，將遵循防制洗錢金融小組「FATF」的《加密貨幣指導方針》\n據聯合報引用知情官員報導，金管會與法務部自去年 11 月起，經過多次研討、協商，最終在本月 17 日達成共識，同意將比照融資性租賃業作法，將加入自律組織的虛擬貨幣業者作為納管對象。\n意味著，不論是從事虛擬貨幣交易平台、交易所，或STO（證券型代幣發行）以外的ICO（首次代幣發行）等業者，只要加入自律組織，都將列入納管範圍；而超商則不直接納入列管。\n官員表示，超商是幫虛擬貨幣業者做代收付的通路，不是虛擬貨幣業，未來可由虛擬貨幣業者自行管理。虛擬貨幣業可透過代收付契約去約束超商，訂定每人的每日購買上限以進行控管，以符合金管會訂定的洗錢防制規定。\n根據金管會資料，目前國內虛擬貨幣自律組織主要有兩大體系，包括「台灣區塊鏈暨加密貨幣自律組織」及「亞太區塊鏈產業自律聯盟」，扣除重疊成員，已有將近二十家加密產業業者加入自律組織，被列入納管範圍。\n接著將報由行政院核定，金管會預計在下半年預告訂定相關子法後，相關規範就可正式上路。\n動區先前報導，金管會在去年原透過發函銀行，讓銀行業要求虛擬貨幣業者落實實名制，但隨著國際監管趨勢明朗，金管會現在將直接納入反洗錢規範管理。\n三大特許業務須申請\n另外據經濟日報報導，如果涉及金管會特許業務，必須提出申請，其餘則要申請進入沙盒實驗。目前虛擬貨幣可能涉及金管會主管的特許業務，主要有三大類型，包括電子支付、匯款及STO。\n金管會預計本月底前出台 STO 相關規範，依規劃，發行金額在一定金額以下者，將採群募機制，一定金額以上則進入沙盒；另外官員指出，由於虛擬貨幣的交換行為或帳戶間的轉移，都將涉及電支或匯款業務的規定，故依規定，除 STO 之外的這兩項業務也必須向金管會申請核准。\n官員表示，在虛擬貨幣業者的納管業務範圍確定後，將會與業者展開溝通，告知須申請的特許業務，或進入監理沙盒。\n報導表示，亞太防制洗錢組織（APG）將於今年八月召開會員大會，此次定案對虛擬貨幣市場的洗錢防制納管有具體進展，也可望對臺灣的評鑑結果有正面助益。\n動區於6月初報導，隨著國際組織對於虛擬貨幣的監管升溫，目前的監管風向可能會讓習慣於點對點（P2P）交易服務的業者面臨衝擊，專精於金融科技科技與監理科技的哈佛法學博士、台大法學院助理教授楊岳平當時就指出：\n「去年 11 月修法將交易所業者納入反洗錢規範時，已經明文朝比照金融業的路線辦理，因此接下來的監管難免會比較嚴格。」\n相關報導\n金管會 STO 草案規劃：募資額 3,000 萬以下採群募概念；3,000 萬元以上進沙盒\n金管會將擬訂證券型代幣募資（STO）規範，Maicoin 的證券型代幣於監理沙盒輔導中\n\n\n《BlockTempo動區動趨》LINE官方號開通囉～立即加入獲得第一手區塊鏈、加密貨幣新聞報導！"],["topImageUrl","https://dkyfoqsw29om1.cloudfront.net/2019/06/64977769_457834314950450_6567388527573598208_n.jpg"],["error",null]]}]}],["createdAt","2019-12-12T16:55:46.606Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",4],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_xKGo3g-HTVqTBBpOjChzkhT4lx_Fry5Dd_aZvLNrEUk"],["name","可靠的楠西桃樂斯"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","ACE王牌數位貨幣交易"],["url","https://www.ace.io/activity/invite-register?invite_code=00025776"],["summary","Copyright © 2018-2019 Ace Digital Innovations Co., Ltd. 王牌數位創新股份有限公司 All Rights Reserved."],["topImageUrl","https://www.ace.io/dda5fd010bfa0160e8edbd6dc90212e6.png"],["error",null]]}]}],["text","台灣唯一完全合法落地交易所，更榮獲經濟部核准補助，嚴守KYC.AML規格，ABA x ACE x ABF=ABE虛擬貨幣實體交易所，打造台灣最大最完整區塊鏈技術，並提供法規.財稅.技術.產品.業務.行銷全方面輔導。\n\n現在註冊ACE完成實名B級認證\n就送超多獎勵回饋金！\n\n盡快把握時間參與活動，並且將此消息分享給親朋好友吧！\n\n註冊邀請碼\nhttps://www.ace.io/activity/invite-register?invite_code=00025776\n心存善念，絕不詐騙"],["id","2y4yg1kklj78c"],["createdAt","2019-12-07T03:10:06.555Z"]]}],["reply",{"__iterable":"Map","data":[["id","ZVYW-24BV0DITCqGkGVB"],["user",{"__iterable":"Map","data":[["id","AVy59B4MyCdS-nWhuapS"],["name","Lucien Lee"],["avatarUrl","https://www.gravatar.com/avatar/166c6d89712db394acce65039c2cfe00?s=100&d=identicon&r=g"],["level",11]]}],["type","NOT_RUMOR"],["text","ACE 交易所最近的新用戶活動到 2019/11/30 過期，新用戶註冊並完成身分認證有新台幣等值 100 元的比特幣回饋。"],["reference","https://medium.com/ace-exchange/ace-events-sep-91b188ce0222"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","ACE Exchange 線上活動總覽：9月"],["url","https://medium.com/ace-exchange/ace-events-sep-91b188ce0222"],["summary","活動一：Hodl 住 ACEX！開薪日來了活動二：ACEX奔月！投福券抽雙倍BTC活動三：註冊送你比特幣！活動四：好友大募集，一起拿ETH！活動五：邀請反佣，最高回饋60%「Hodl 住ACEX 開薪日來啦」活動正式上線！活動期間用戶持倉10,000 顆(含)以上ACEX，即可免費均分1.5顆BTC！【活動辦法】欲參加活動用戶，於2019.08.30 00:00:00至2019.09.08 23:59:59期間內(共10日)，帳戶可用餘額持續持有10,000顆(含)以上 ACEX，可於2019.09.10均分總獎金1.5顆BTC。【注意事項】1.持倉時間：2019.08.30 00:00:00至2019.09.08 23:59:59。2.可用餘額定義：總額扣掉處理中資金。3.ACE 團隊將於活動期間（2019.08.30 00:00:00至2019.09.08 23:59:59）每日進行不定時、多次隨機快照。4.BTC均分獎勵將於2019.9.10 23:59:59 前發送。5.如用戶不符以上活動規則，則視同取消參與活動資格。6.ACE Exchange保留活動最終修改、解釋權。詳細活動內容敬請參考：開薪日活動主頁『ACEX奔月！投福券抽雙倍BTC』活動開跑啦！中秋月圓人團圓，快來ACE投福券～凡活動期間投福券至獎金池內（每張抽獎福券價值：50 ACEX（顆））能獲得比特幣或特別獎的幸運兒可能就是你！詳細活動內容敬請參考：https://event.ace.io/2019/201909acextomoon/【活動時間】2019.09.12 12:00 (UTC+8) — 2019.09.17 18:00 (UTC+8)【活動對象】有購買ACEX之用戶【活動辦法】1.前往活動表單，依照表單填寫UID及欲投入的抽獎福券張數（每張福券價值：50 ACEX），並於2019.09.17 18:00前完成轉幣至指定錢包。 2. 2019.09.18 18:00 前寄發參加成功確認信給活動參加者。 3.ACE Exchange 活動主頁與官方社群（FB &Line@主頁＆Telegram）將於 2019.09.19 18:00前公佈本次最終獎池總金額與中獎名單。 4.本次活動預計抽出10位得獎者均分最終獎金池獎金，並將發送等值BTC為獎勵。 5.除10位得獎者外，再加碼抽出4位用戶享有ACE Exchange特別獎 6.BTC獎勵將依照關閉獎金池當日ACE Exchange 18:00 之ACEX/USDT及USDT/BTC匯率為主。 7.特別獎得獎者應於2019.09.25 18:00前，主動私訊ACE Exchange 粉專，並提供姓名、Email及電話，超過時間未提供者，視同放棄領獎資格。 8.ACE Exchange 將於2019.09.30前，以Email完成寄送特別獎電子/ 實體票券獎勵。四.注意事項：1.每個UID不限投福券次數，每張福券價值為50 ACEX。 2.本次活動時間截至2019.09.17 18:00:00止，超過時間轉幣視同無效。 3.填寫表單並完成轉幣後，恕不接受要求取消、退還ACEX。 4.被抽中的10名獎金得獎者，當次UID不會再放入特別獎抽獎池中。 5.BTC獎勵將依照關閉獎金池當日ACE Exchange 18:00 之ACEX/USDT及USDT/BTC匯率為主。6.2019.09.18 18:00 前寄發［參加成功確認信］給活動參加者。 7.ACE Exchange 活動主頁與官方粉專將於 2019.09.19 18:00前公佈本次最終獎池總金額與中獎名單。8. 每一UID僅限中獎一次。 9. ACE Exchange將依稅法規定，主動申報得獎者之所得，若中獎獎品所得總額超過新臺幣1,001元整，得獎者應配合繳交相關資料，若未於期限內提供則視為自動放棄得獎資格。若中獎獎品所得總額超過新臺幣20,000元整，需另先行繳納10%機會中獎稅額。 10. 如用戶不符合以上活動規則，ACE Exchange將予以退幣處理；退幣處理時間將依實際情況有所變動，最久可能達1~2個月，且退幣燃料費成本（每筆退幣將酌收 50 ACEX）由用戶承擔，敬請見諒。 11. ACE Exchange保留隨時修正、暫停、終止活動辦法及變更獎項內容之權利。🏵ACE Exchange 開啟你的數位貨幣之旅🏵下載並註冊，就送你比特幣(NT$100)！【活動日期】2019/11/01 00:00 至 2019/11/30 23:59:59 （GMT+8）【活動說明】⓵ 下載ACE Exchange App⓶ 註冊並通過安全等級A「身分認證」⓷ 即可獲得NT$100比特幣新戶好禮！【注意事項】1.每一個帳號限得獎一次，不得重複得獎。2.下載ACE App、完成註冊並通過安全等級A「身分認證」後，ACE Exchange 會於3個工作日內發放獎金(BTC )。3.通過身份認證日期以「申請日期」為基準。（申請時間為2019/11/01至 2019/11/30 23:59:59，但用戶須於2020/01/15 23:59:59前通過安全等級A身份認證，才具有獎勵資格。）4.幣價基準：發放當天 10:00 CoinMarketCap BTC/USD價格為基準，USD:TWD=30:1。5.BTC發放顆數計算：四捨五入，取到小數點後第八位。6.參加本活動者同意所有參加者所留存或產生之任何參與活動的資料及記錄，皆以主辦單位的電腦系統與時間的記錄為主。7.以任何駭客或其它非法行為破壞活動規則者，其參賽資格無效，主辦單位保留法律追訴權。8.上述活動辦法依主辦單位公告為主；主辦單位具有審核申請者資格、活動調整、更改、取消、解釋或裁決之權利。只要邀請好友註冊ACE Exchange 並通過「身份認證」，雙方皆可拿到 NT$50 等值 ETH👫👫👫👫！🎁回饋數量無上限，歡迎大家一起來體驗🎁【活動日期】2019/11 /01 00:00 至 2019/11/30 23:59:59 （GMT+8）.【注意事項】1. 交易換算之新台幣以ACE計算為準。2. ACE Exchange 會於3個工作天內發放符合資格之獎勵。3. 幣價基準：發放當天 10:00 CoinMarketCap ETH/USD價格為基準，USD:TWD=30:1。4.ETH發放顆數計算：四捨五入，取到小數點後第四位。5. 參加本活動者同意所有參加者所留存或產生之任何參與活動的資料及記錄，皆以主辦單位的電腦系統與時間的記錄為主。6. 以任何駭客或其它非法行為破壞活動規則者，其參賽資格無效，主辦單位保留法律追訴權。7. 上述活動辦法依主辦單位公告為主；主辦單位具有審核申請者資格、活動調整、更改、取消、解釋或裁決之權。他做交易，你得回饋。為了回饋每個加入 ACE 的用戶，我們推出了『返佣推薦碼』的活動，讓每位用戶皆有機會享受高額回饋。【活動日期】2019/11 /01 00:00 至 2019/11/30 23:59:59 （GMT+8）【活動對象】無論哪個用戶等級，都可以參加【邀請方法】先進入「個人中心」的「邀請返佣」頁面。(1) 邀請碼在「我的邀請碼」有一組屬於自己的邀請碼 ( 共8位 )，一旦邀請好友註冊時，好友可在註冊欄最下方輸入您的邀請碼，好友即成為您的邀請用戶。(2) 邀請連結在邀請碼下方有一個「邀請連結」，將此連結複製給好友，好友即可透過此連結進入註冊的畫面，註冊欄中會顯示您的邀請碼，代表邀請成功。(3) QR Code好友可直接掃描邀請連結下方的「 QR Code 」進入註冊畫面，註冊欄中會顯示您的邀請碼，代表邀請成功。三、返佣計算方式( 一級用戶交易手續費 x 50% ) + ( 二級用戶交易手續費 x 10% )※ 舉例若用戶 A 邀請好友 B 和 M ，而好友 B 再邀請好友 C，則對於用戶 A 而言：返佣 = ( B 交易手續費 + M 交易手續費 ) x 50 % + C 交易手續費 x 10 %【注意事項】1. 只有邀請的好友實際交易後，才會得到反佣。2. 邀請碼僅「註冊頁面」可輸入，若無輸入則無法回溯。3. 參加本活動者同意所有參加者所留存或產生之任何參與活動的資料及記錄，皆以主辦單位的電腦系統與時間的記錄為主。4. 以任何駭客或其它非法行為破壞活動規則者，其參賽資格無效，主辦單位保留法律追訴權。5. 上述活動辦法依主辦單位公告為主；主辦單位具有審核申請者資格、活動調整、更改、取消、解釋或裁決之權。"],["topImageUrl","https://miro.medium.com/focal/1200/632/50/12/1*Aa4me6A8DxRo0Z_rA4lM6Q.jpeg"],["error",null]]}]}],["createdAt","2019-12-12T17:09:50.278Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",4],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_xKGo3g-HTVqTBBpOjChzkhT4lx_Fry5Dd_aZvLNrEUk"],["name","可靠的楠西桃樂斯"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","ACE王牌數位貨幣交易"],["url","https://www.ace.io/activity/invite-register?invite_code=00025776"],["summary","Copyright © 2018-2019 Ace Digital Innovations Co., Ltd. 王牌數位創新股份有限公司 All Rights Reserved."],["topImageUrl","https://www.ace.io/dda5fd010bfa0160e8edbd6dc90212e6.png"],["error",null]]}]}],["text","台灣唯一完全合法落地交易所，更榮獲經濟部核准補助，嚴守KYC.AML規格，ABA x ACE x ABF=ABE虛擬貨幣實體交易所，打造台灣最大最完整區塊鏈技術，並提供法規.財稅.技術.產品.業務.行銷全方面輔導。\n\n現在註冊ACE完成實名B級認證\n就送超多獎勵回饋金！\n\n盡快把握時間參與活動，並且將此消息分享給親朋好友吧！\n\n註冊邀請碼\nhttps://www.ace.io/activity/invite-register?invite_code=00025776\n心存善念，絕不詐騙"],["id","2y4yg1kklj78c"],["createdAt","2019-12-07T03:10:06.555Z"]]}],["reply",{"__iterable":"Map","data":[["id","LlYP-24BV0DITCqGYWWq"],["user",{"__iterable":"Map","data":[["id","AVy59B4MyCdS-nWhuapS"],["name","Lucien Lee"],["avatarUrl","https://www.gravatar.com/avatar/166c6d89712db394acce65039c2cfe00?s=100&d=identicon&r=g"],["level",11]]}],["type","RUMOR"],["text","獲得經濟部中小企業補助計畫是他們集團的ABA亞洲區塊鏈加速器，並不是 ACE 交易所。"],["reference","https://medium.com/ace-exchange/aba%E6%89%93%E9%80%A0%E5%8F%B0%E7%81%A3%E6%88%90%E7%82%BA%E4%BA%9E%E6%B4%B2%E5%8D%80%E5%A1%8A%E9%8F%88%E7%AC%AC%E4%B8%80%E4%B8%AD%E5%BF%83-%E5%85%A9%E5%B9%B4%E5%B8%B6%E5%8B%95%E7%94%A2%E5%80%BC100%E5%84%84-fbd200d2bb4d"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","ABA打造台灣成為亞洲區塊鏈第一中心兩年帶動產值100億"],["url","https://medium.com/ace-exchange/aba%E6%89%93%E9%80%A0%E5%8F%B0%E7%81%A3%E6%88%90%E7%82%BA%E4%BA%9E%E6%B4%B2%E5%8D%80%E5%A1%8A%E9%8F%88%E7%AC%AC%E4%B8%80%E4%B8%AD%E5%BF%83-%E5%85%A9%E5%B9%B4%E5%B8%B6%E5%8B%95%E7%94%A2%E5%80%BC100%E5%84%84-fbd200d2bb4d"],["summary","「企業上鏈」產業新趨勢，亞洲最完整區塊鏈生態系「ABA」為您加速知名連續成功創業家林弘全從台灣出發，推動全球領先區塊鏈儲存落地應用區塊鏈產業已成為全球顯學，根據資誠《2018全球區塊鏈調查報告》，全球已有84%企業投入區塊鏈領域研究，美國資訊科技研究暨顧問公司Gartner預估，其產值預估於2030年將超過超過3.1兆美元。為協助台灣區塊鏈產業發展，並導入優秀國際區塊鏈項目資源，亞洲區塊鏈加速器（Asia Blockchain Accelerator，簡稱ABA），集結ACE法幣-數位貨幣交易所（ACE Exchange）與ACE區塊鏈基金(ACE Blockchain Fund，簡稱ABF) 資源，將完整提供區塊鏈領域的創業家及企業加速、投資基金、行銷廣宣及深入輔導等線上線下資源。此計畫更榮獲「經濟部中小企業處」107年度中小企業創育機構發展計畫核准補助，ABA集結產官學媒全方位資源輔導海內外具潛力的區塊鏈新創加速成長，打造台灣成為亞洲區塊鏈第一中心，預估兩年帶動台灣區塊鏈產值100億新台幣！記者會現場展現優異成果，邀請到知名連續成功創業家林弘全(無名小站 2003–2007 Yahoo M&A, flyingV 2012–2017 exit, BiiLabs 2017~)，推動區塊鏈技術「分布式存儲加速平台」，由台灣出發，ABA助力孵化、打造全球領先的落地應用項目，透過ABA導師，亦為亞洲募資最快紀錄「GIFTO」為其再優化區塊鏈業務模式及匯集國際資源！企業上「鏈」！ABA亞洲最完整區塊鏈生態系助攻，兩年帶動台灣區塊鏈產值100億ABA執行長潘奕彰表示：深信區塊鏈將是未來改變世界的技術，ABA亞洲區塊鏈加速器率領ACE法幣數位貨幣交易所與ABF區塊鏈基金，掌握全球區塊鏈資源及加速器輔導優勢，打造亞洲最完整區塊鏈生態系，預估兩年可帶動高達100億台幣產值！ABA每年至少加速10家台灣企業、幫助5家龍頭台灣企業擴展海外業務或國際新創來台落地、超過5000萬商務資金等，更提供全球資源網絡，如區塊鏈業務輔導、財會法律、媒體公關、區塊鏈技術策略、投資人關係、籌融資、全球影響力等，結合加速器、交易所、基金助區塊鏈企業加速！亞洲最大區塊鏈孵化器LongHash，為ABA策略夥伴及國際資源，擁有《華爾街日報》、《紐約時報》資歷的創辦人Emily Parker親自來台灣響應盛會，介紹LongHash優勢為敏銳數據分析和淺顯易懂新聞，幫助全球企業及用戶更了解數位貨幣發展及動向，分享美國、新加坡等孵化成功經驗，近期也將完成歐亞10個城市加速器任務，更讚許ABA串連國際知名LongHash、BitTemple等區塊鏈加速器，讓台灣區塊鏈更上層樓！台灣孵化、全球領先落地應用！知名連續成功創業者林弘全打造分布式區塊鏈存儲加速平台ABA亞洲區塊鏈加速器提供「輔導x通路x資金」一條龍式區塊鏈生態系資源，目前正與台韓等多家企業合作加速區塊鏈項目。現場邀請台灣區塊鏈新星，知名連續成功創業家林弘全(無名小站 2003–2007 Yahoo M&A, flyingV 2012–2017 exit, BiiLabs 2017~) 攜手與Qinfra合作，由台灣孵化、打造全球領先落地應用「Poseidon Network分布式區塊鏈存儲加速平台」的區塊鏈技術，利用台灣硬體領先全球優勢，將全球閒置無用的存儲空間自動釋放，供各種網路影音加速使用，如全球6000萬用戶的Uplive直播龍頭及全球前三大存儲設備公司，成功打造全球第一去中心化存儲加速區塊鏈項目！ABA集結國內外重量級專家顧問，如「國際知名區塊鏈項目GIFTO」創辦人田行智Andy，擁有亞洲最快一分鐘內成功募集 3,000 萬美元的成功經驗，也是2017年第一個大型上鏈企業；新創產業權威「瀛睿律師事務所」合夥人簡榮宗及「台灣天使投資協會」秘書長蘇拾忠都親自輔導給予意見；全球擁有6,000萬用戶及年收入超過 1 億美元的國際級直播平台「Uplive」行銷資源支持，ABA站在巨人肩上輔導海內外具潛力的區塊鏈新創加速成長，讓國際區塊鏈應用落地台灣、台灣企業走向國際，促進數位貨幣更多元應用場景及商業合作，共同為台灣區塊鏈加油！"],["topImageUrl","https://miro.medium.com/max/1200/1*jHWdVKvQVo3aGUVKwkbGnQ.jpeg"],["error",null]]}]}],["createdAt","2019-12-12T17:01:59.598Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",3],["user",{"__iterable":"Map","data":[["id","j4S8C_KBTd9Mn5Jo1sbkIl-yNV90jK1iaYnhabtSK15zNCJ6w"],["name","激勵性的五峰瑪麗"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","桃園振興觀光義勇軍"],["url","http://tourcash.tycg.gov.tw/"],["summary","桃園振興觀光義勇軍\n \n \n \n 活動介紹\n 立即申領消費者中獎專區 \n 業者專區\n 可兌換店家\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n coming soon ...\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n 謝謝你好朋友股份有限公司 | LINE@ ID:@3qmf-tycg | 客服時間：週一至週五 09:00~18:00\nCopyright ©2020 by Thankyoumyfriends Co., Ltd. All Rights reserved."],["topImageUrl",null],["error",null]]}]}],["text","限桃園市民\nhttp://tourcash.tycg.gov.tw/ 記得6/22(一)上午九時，去登錄。"],["id","249dbbggfj44r"],["createdAt","2020-06-21T13:39:54.183Z"]]}],["reply",{"__iterable":"Map","data":[["id","QNmh2nIBb3SlMKoAFMkP"],["user",{"__iterable":"Map","data":[["id","_1YnAG8BV0DITCqGm7go"],["name","uienwt"],["avatarUrl",null],["level",18]]}],["type","NOT_RUMOR"],["text","桃園市觀光旅遊局長楊勝評表示，6月22日起，市民可以到指定網站填妥身分證字號、桃園市民卡號及手機門號等資料，每個身分證字號限登記抽獎1次，且身分證與市民卡的持有者須為同一人，市府將在6月30日辦理抽獎並發送電子旅遊券簡訊，中獎者從7月1日起就可使用。"],["reference","https://www.cna.com.tw/news/aloc/202005270089.aspx"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","桃園市府振興觀光產業徵義勇軍送500元旅遊券 | 地方 | 中央社 CNA"],["url","https://www.cna.com.tw/news/aloc/202005270089.aspx"],["summary","（中央社記者吳睿騏桃園27日電）為帶動地方觀光產業發展，桃園市政府規劃「徵求桃園振興觀光義勇軍」電子旅遊券方案，市民只要持市民卡及身分證上網登記，就有機會贏得限量1萬組、價值新台幣500元的旅遊券。桃園市副市長李憲明上午出席市政會議後接受媒體聯訪指出，隨著國內疫情趨緩，市府近期規劃「徵求桃園振興觀光義勇軍」電子旅遊券執行方案，將提供市民限量1萬組、每組新台幣500元的電子旅遊券，希望提升桃園觀光，振興相關產業。桃園市觀光旅遊局長楊勝評表示，6月22日起，市民可以到指定網站填妥身分證字號、桃園市民卡號及手機門號等資料，每個身分證字號限登記抽獎1次，且身分證與市民卡的持有者須為同一人，市府將在6月30日辦理抽獎並發送電子旅遊券簡訊，中獎者從7月1日起就可使用。楊勝評指出，電子旅遊券適用的範圍，除旅館民宿外，也可進行餐飲消費，包括商圈、觀光工廠等，為方便民眾使用，500元電子旅遊券分為5個QR Code、各100元的方式發送至手機，等同為現金券，使用過後的QR Code就會自動失效，但電子旅遊券不找零，提醒民眾多加留意。（編輯：戴光育）1090527本網站之文字、圖片及影音，非經授權，不得轉載、公開播送或公開傳輸及利用。下載中央社「一手新聞」 app，每日新聞不漏接！"],["topImageUrl",null],["error",null]]}]}],["createdAt","2020-06-22T06:04:49.043Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",2],["user",{"__iterable":"Map","data":[["id","j4S8C_ITHM5Z0AewWmcMUHMt9bmYIGkqR4Ym9bwRzCN-nYE5E"],["name","貫徹始終的桃源史丹佛"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","加入meellove - 在這裏結識朋友"],["url","https://meellove.com/index.html#/m/home/trend/list"],["summary","關於我們 | 服務條款 | 隱私政策 | 退款協議 | 幫助中心 | 聯係我們 Copyright ©2024 HONGKONG JIHONGYUN TRADE DEVELOPMENT CO., LIMITED(UNIT D 16/F ONE CAPITAL PLACE 18 LUARD ROAD WAN CHAI HK) All Rights Reserved."],["topImageUrl",null],["error",null]]}]}],["text","https://meellove.com/index.html#/m/home/trend/list"],["id","4hmw8tjmsw6a"],["createdAt","2024-04-04T11:39:09.659Z"]]}],["reply",{"__iterable":"Map","data":[["id","-vUmoIsBAjOeMOkliqF5"],["user",{"__iterable":"Map","data":[["id","AVriAlOoyrDaTqlmmqhC"],["name","Lin"],["avatarUrl",null],["level",22]]}],["type","RUMOR"],["text"," 請小心交友詐騙網站。\n有許多被害人都是經由網友引導，下載來路不明的交友App，或註冊不知名的交友網站，甚至也有被轉介到假冒大型交友網站的案例，由所謂的網站客服出面，不斷要求民眾以刷卡、匯款、購買虛擬貨幣等方式升級會員資格、開通聊天功能，到最後App、網站無預警關閉，讓不知情的民眾付出了大筆金額，卻只換來一場空。\n "],["reference","https://0800happy.com/11397/\nhttps://www.mirrormedia.mg/story/20220508soc013/\nhttps://www.appledaily.com.tw/local/20220508/WGLUHGICNBHFRD6YYMXKCT6EHQ/"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","【交友詐騙】起疑點:要你註冊非上架在APP商店的聊天程式"],["url","https://0800happy.com/11397/"],["summary","交友詐騙真的是越來越高明，再公開一則來救世勸世一下。在一切都很正常很自然的情況下，你的腦也可能被洗一半而不自知了，此時要你下載另一個APP就會完全不疑有它..."],["topImageUrl",null],["error",null]]},{"__iterable":"Map","data":[["title","銀行行員誤入剝皮交友網站　為解鎖遭詐125萬元"],["url","https://www.mirrormedia.mg/story/20220508soc013/"],["summary","台北市1名20多歲林姓男子，今年3月在交友軟體認識1名女網友，相談甚歡互加LINE聊天，沒多久女網友向林男表示，因為要前往上海工作，可能沒辦法再繼續用LINE，為方便日後聯繫，邀請林另外下載交友軟體Faith，林依約下載後，按客服指示購買泰達幣轉入指定錢包地址，等同取得「永久會員」資格，同時還能開啟對話功能。"],["topImageUrl",null],["error",null]]},{"__iterable":"Map","data":[["title","看個資要收付費！癡情男真心換絕情　網交慘遭詐125萬｜蘋果新聞網｜蘋果日報"],["url","https://www.appledaily.com.tw/local/20220508/WGLUHGICNBHFRD6YYMXKCT6EHQ/"],["summary","台北市年約20多歲的林姓男子今年3月，在交友軟體上認識1名女網友，她邀請林男下載另一個交友軟體「Faith」，雙方聊天過程中，只要談及地址、電話等個資，客服系統便要求林男轉入泰達幣才能「解鎖」。林男一切照單全收，前後匯出125萬，卻始終沒見到對方，直到「Faith」無法登入，林男驚覺遭詐。"],["topImageUrl",null],["error",null]]}]}],["createdAt","2024-04-18T05:18:21.620Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_mI3eOi52-Ww8Qq5y5k_tJ3CWNHrGzRuHzrVl8C-IC94"],["name","老練的新莊傑森"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","早安健康｜抗氧化物質比綠茶多137倍！抗疲勞7大強食"],["url","https://bit.ly/2EEIf1w"],["summary","【早安健康／曾大容報導】在市場、超市採買時，選擇越多越茫然，如何在有限的預算下，買到最多對健康有益處的食材呢？謹記以下由國外多個知名營養師提出的七個最強食材，讓你的餐桌成為消解全家人疲勞的最強補給站吧！\n抹茶，多酚是綠茶的137倍！\n美國知名營養師弗朗西絲·拉吉曼-羅斯認為，抹茶即將作為一種營養豐富的食品，在歐美地區大流行！將茶葉乾燥之後再研磨成粉的抹茶，這樣的特殊製法讓它的抗氧化物質－多酚，比綠茶還要多137倍！\n\n而且咖啡因是一般咖啡的一半，特別推薦給在下午容易感到疲勞、想睡，但攝取過多的咖啡因晚上又會睡不著的人。不過要注意到的是，小心別攝取過多糖分，盡量選擇無糖或減糖的粉末來飲用。\n香蕉\n英國暢銷書作家、同時也是營養師的瑪莉蓮格連威利的醫師認為，接近傍晚或天氣陰暗時，容易情緒低落、感到疲勞，但自己可能沒有發覺，所以適時的補充血清素、也就是提升「快樂荷爾蒙」來說　再搭配糙米全麥燕麥等未精緻過的碳水化合物一起食用的話，可以促進胰島素的分泌、幫助色胺酸的傳達，為體內製造出更好的血清素。\n藍莓\n藍莓含有大量的花色素苷，也含有比其他的水果更豐富的抗氧化物質，英國營養學專家蓋塔羅布認為，抗氧化物質能夠修復自由基等有害物質對人體造成的不好影響、舒緩眼睛疲勞、守護泌尿器官的健康、維持強健的體力。\n青甜椒\n蓋塔羅布認為，維生素C可以強化免疫力、減輕疲勞，一般我們可能認為柑橘類維生素C含量高，但青甜椒的維生素C是柑橘類的3倍！尤其紅色的甜椒含有更多的β-胡蘿蔔素、植化素，具有的抗氧化和抗發炎的效用更強。\n\n\n更多能夠消除疲勞的好食物，下一頁與您分享！"],["topImageUrl","https://c1.staticflickr.com/1/883/26258353237_9d1b855bdc_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康｜腸道水腫讓你便祕、腰圍粗！這樣做腰瘦5公分"],["url","http://bit.ly/29suxCa"],["summary","【早安健康／周舒涵編譯】您是否老是覺得肚子脹脹的，又有惱人的便祕症狀呢？快跟著下面的自我檢查表，來看看自己是不是屬於腸道水腫的患者，以及就算因為腸道水腫導致便祕的話也不用太過擔心，日本腸道名醫小林弘幸指出，「每消除腸道水腫5毫米，腰圍就可減5公分！」跟著吃他所推薦的蜂蜜蘿蔔泥優格，再加上簡單的解便祕按摩體操，就可以輕鬆解決您的便祕煩惱。\n\n \n腸道水腫造成的便祕，導致身體發胖腸道水腫是因為大腸環境惡化，吸收了多餘的水分造成水腫所導致的發炎反應，只要有長時間便祕的現象，罹患腸道水腫的可能性就會提高。罹患腸道水腫的話，大腸的蠕動會惡化，吸收能力也會下降，吃下去的食物可能會堆積成為皮下脂肪或內臟脂肪，導致身材肥胖。如果想要瘦下來的話，改善便祕症狀是最重要的第一件事。\n\n \n跟著以下五點，確認自己有沒有腸道水腫的症狀！ \n ○一個月中有數次3天以上沒有排便的狀態。 \n ○使用5年以上的助排泄藥物。 \n ○肚子感覺起來硬硬的很結實。 \n ○常常會有脹脹的感覺。 \n ○雖然會定期排便但每次都會有排不乾淨的感覺。 \n \n 以上5點，只要有符合超過1項，就必須要注意可能患有腸道水腫的症狀。如果發現自己有腸道水腫或者便秘症狀的話，快跟著小林弘幸醫師的建議，從飲食與按摩體操著手，雙管齊下消除惱人的排毒問題。\n\n \n吃蜂蜜蘿蔔泥優格，有效改善症狀小林弘幸醫師推薦，如果有腸道水腫與便祕症狀，可以食用蜂蜜蘿蔔泥優格改善，其中蜂蜜所含的寡糖可以促進腸道中比菲德氏菌的增加。另外攝取大豆、薯類或穀類，會增加糞便體積的非水溶性膳食纖維相比，若想排除腸道囤積已久的廢物，搭配白蘿蔔中可以使糞便軟化的水溶性膳食纖維較為適合。\n\n \n每天10分鐘超簡單按摩體操，告別腸道水腫與便祕 \n步驟１雙腳張開與肩同寬站立。 \n \n ２右手緊緊捏住位於右側的恥骨上方腰部。\n \n \n ３左手捏住位於左側的肋骨下方腰部。\n\n \n \n ４順時針慢慢的大幅轉腰5圈，可以的話最好搭配兩隻手的搓揉。 \n \n ５再逆時針慢慢的大幅轉腰5圈。（換方向轉動的時候兩隻手抓住的位置不用改變） \n \n ６一天進行5～10次，時間總計大約10分鐘。 \n \n \n \n 【延伸閱讀】\n\n一日瘦身飲食表，點心3點吃不發胖、睡前吃優格清腸消便秘！\n\n保溫杯煮黑豆茶！3帖減肥茶消水腫、不便秘\n\n早上3分鐘排毒操！喚醒腸道，如廁好順暢"],["topImageUrl","https://farm6.staticflickr.com/5617/20334358055_8c0d8ba091_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康嚴選"],["url","https://shop.everydayhealth.com.tw/l.php?1c8exz&openExternalBrowser=1"],["summary","【九月慶中秋】親友相聚送禮表心意，滿額再加贈超值好禮\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\t\t●●●●●●●●●●●●●●●●\t\t\t\t\t\n\n\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\n\t\t\n\n\n\n\n\n個資安全加密\nSSL憑證安全付款 \n\n\n\n \n\n購物滿1200元\n整筆訂單免運費 \n\n\n\n \n\n加入LINE好友\n立即現折100元 \n\n\n\n \n\n立即來電訂購 \n02-5596-7262\n\t\n\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\n\t\t\t\t\n\t\t\n\n\t\t\t\n\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tAmericanTraveler 20吋超輕量抗刮行李箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\n\t\n\t\t\n\t夏養三伏，冬補三九\n\t\n\t\t\n\t\t\n\t\t\t一年之中最熱的三伏即將到來\n是中醫預防醫學中「冬病夏治」的好時機\n分別是夏至後的第三個庚日「初伏」\n第四個庚日「中伏」、立秋後第一個庚日「末伏」\t\t\n\t\n\t\n\t\t\t\n\n\t\t\t\n\n\t\t\t「夏季要一天洗幾次頭才夠呢？頭髮多只要一流汗頭皮癢，洗完還是悶悶的！」\n「每天都要戴著安全帽騎車通...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t一年四季都適合端上桌的快手料理。備料迅速、不會花太多時間，滋味香醇潤口，忙碌的時候也能好好上菜，可說...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t8more老客人梓瑩Janet：「隨著人生一路轉折，我認識到生命就是能量的流動，心胸越開放不執著，就...\n\t\t\n\t\t\t\n\n\t\n\t\n\t\n\t\n\n\t\n\n\n\n\n\n\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t客服專線 02-5596-7262 ｜服務時間週一至週五 9:30-12:30/13:30-18:00\n\n\t\t\t©2018 早安健康股份有限公司版權所有，轉載必究 Copyright Everyday Health Co,Ltd All Rights Reserved"],["topImageUrl","https://ftp.pic.everydayhealth.com.tw/edh_upload/website_info/pic_logo_1.png?1475814226"],["error",null]]}]}],["text","(cocktail)贏綠茶137倍這杯最抗疲勞\nhttps://bit.ly/2EEIf1w\n\n(drop)【便祕、腰圍粗】這樣做消腸道水腫，還能腰瘦5公分\nhttp://bit.ly/29suxCa\n\n(no)拒絕脂溶性農藥下肚！天然食材萃取的蔬果清潔劑，友善環境安心推薦2件9折\nhttps://shop.everydayhealth.com.tw/l.php?1c8exz&openExternalBrowser=1"],["id","ymcxsh2sw50j"],["createdAt","2018-04-12T04:47:31.785Z"]]}],["reply",{"__iterable":"Map","data":[["id","eB56TWMBSH_MLFhI32G6"],["user",{"__iterable":"Map","data":[["id","AVriAlOoyrDaTqlmmqhC"],["name","Lin"],["avatarUrl",null],["level",22]]}],["type","NOT_ARTICLE"],["text","這是商業活動廣告 "],["reference",""],["hyperlinks",null],["createdAt","2018-05-11T04:34:48.382Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_iwVjDjINyiDpn7RbTFqTWf6CzdOxSJbasBOvvyiFAaM"],["name","令人信服的竹北南茜"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","早安健康｜致死率比癌症高！預防更年期骨質疏鬆飲食對策"],["url","https://bit.ly/2rYuN4b"],["summary","【早安健康／余雅雯（中醫師）】\n更年期的骨質疏鬆問題\n\n更年期還有一個需要特別注意的問題就是骨質疏鬆，上了年紀的人，因髖關節骨折而致死的機率甚至比癌症還高。\n\n女性過了三十五歲，骨本會隨著年齡慢慢的減少，所以鼓勵女性在三十五歲前一定要存夠骨本。骨質疏鬆一開始是不會有感覺的，直到常常感到腰痠背痛，背越來越駝，而且每次量身高都變得越來越矮，才會開始意識到這個問題。骨質疏鬆嚴重的話，有可能打個噴嚏、輕微跌倒，就會造成不小的意外，所以上了年紀的女性一定要特別小心，尤其居家安全措施必須做好。\n\n女性隨著更年期的報到，動情激素減少，會造成骨骼中鈣質的析出，而且降低維生素D的活性。偏偏這個年齡腸胃道吸收並不如年輕，即使吃一樣的食物，對於鈣的吸收也沒有那麼好，導致骨質密度減少，就會越來越疏鬆，造成腰痠背痛等現象。如果用影像學去看骨質疏鬆的骨頭，會發現中空而且疏鬆，就跟海砂屋一樣，其實是骨頭因疏鬆而變薄、變脆弱，並且容易造成骨折。\n中醫治療骨質疏鬆對策\n\n中醫稱骨質疏鬆為「骨萎」，由於腎主骨，因此骨萎除了與腎氣衰竭有關，也與任督二脈衰竭相關。一般人往往有個錯誤的迷思，以為面對骨質疏鬆問題，只要不斷補鈣就好，許多老人家也會吃維骨力來避免骨本流失。事實上如果腎氣沒有調節好，那麼再好的保健食品都吸收不了，所以腎氣一定要充足。\n\n腎為先天之本，補強之後，後天的氣血循環才會好，並且發揮真正的功能。中醫對於骨萎的治療重點就是補腎，藥材上常常會使用補腎的左歸丸、右歸丸、龜鹿二仙膠，補脾胃氣血的八珍湯、六君子湯。保健食品當然可以吃，但同時調節腎氣，才能讓吸收更好。\n\n因此除了葡萄糖胺或維骨力等保健食品外，建議從補充腎氣著手，例如龜鹿二仙膠、杜仲、獨活、肉蓯蓉、熟地、大補精髓，可促進成骨細胞增殖，抑制破骨細胞活性，並且經由腎氣系統的提升，補充全身的骨本。\n骨質疏鬆飲食對策\n\n骨質疏鬆，可以透過X光骨質吸收儀來測量骨質密度，其結果會與正常成人最高密度相比較，若標準差低於二點五即為骨質疏鬆症。\n\n根據衛生福利部食品藥物管理署資料指出，國人鈣質建議攝取量如下：\n\n \n \n 一至三歲\n 五百毫克\n \n \n 四至六歲\n 六百毫克\n \n \n 七至九歲\n 八百毫克\n \n \n 十至十二歲\n 一千毫克\n \n \n 十三至十八歲\n 一千兩百毫克\n \n \n 十九歲以上成人、銀髮族\n 一千毫克\n \n \n\n\n\n35歲前是存骨本黃金期！下一頁中醫師介紹骨質疏鬆預防食療"],["topImageUrl","https://c1.staticflickr.com/1/954/42118070562_e6548e00d7_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康｜水果飯前吃還是飯後吃才對？聽聽專家怎麼說"],["url","http://bit.ly/28IfypE"],["summary","【早安健康／Hero祖雄（FISAF國際體育有氧體適能聯盟認證專業基礎核心訓練師和體適能指導員）】主張飯前吃水果的人，認為方便腸胃吸收，有助於維他命的吸收。而且這樣做還能控制食量，減少正餐攝取精緻澱粉的機會。甚至還有一種危言聳聽的說法是認為，飯後吃水果會讓水果在腸胃中滯留太久，產生發酵、有機酸，引起腹脹、腹瀉等問題。 \n \n而主張飯後吃水果的人，則是認為飯前吃水果容易造成熱量過高，與血糖快速升高的問題。因為刺激胰島素大量分泌，長久下來會導致胰島素產生抗阻性的問題，進一步引起血糖過高與脂肪囤積的疾病。 \n \n以上兩種說法是截然不同的理念，對於一般民眾來說，選擇相信任何一邊都是有可能的！我們先一一來看看箇中原因。 \n \n \n飯前吃水果有助於腸胃吸收嗎？ \n答：會，單獨吃下水果，比起與眾多食物一起吃，更方便吸收利用，也有助於維他命的吸收。但正是因為吸收快，血糖升高得也快，糖分在血液中份量比例越來越高，會提高血液的酸性而開始破壞血管！此時身體會分泌胰島素來快速將糖分帶入細胞中利用，過多的糖分會馬上被轉換成三酸甘油脂，再透過血液帶到全身各處，形成脂肪囤積起來。 \n \n血糖快速升高對於健康絕對沒有任何好處，而健康養生的第一個觀念，就是要盡量控制血糖不讓它快速升高。維持血糖的穩定正是維持健康一輩子的課題，所以單從這一點就能清楚知道，飯前吃水果帶來的壞處了吧？"],["topImageUrl","https://farm8.staticflickr.com/7453/27028229084_4fd7961427_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康嚴選"],["url","https://shop.everydayhealth.com.tw/l.php?1cg50p"],["summary","【九月慶中秋】親友相聚送禮表心意，滿額再加贈超值好禮\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\t\t●●●●●●●●●●●●●●●●\t\t\t\t\t\n\n\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\n\t\t\n\n\n\n\n\n個資安全加密\nSSL憑證安全付款 \n\n\n\n \n\n購物滿1200元\n整筆訂單免運費 \n\n\n\n \n\n加入LINE好友\n立即現折100元 \n\n\n\n \n\n立即來電訂購 \n02-5596-7262\n\t\n\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\n\t\t\t\t\n\t\t\n\n\t\t\t\n\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tAmericanTraveler 20吋超輕量抗刮行李箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\n\t\n\t\t\n\t夏養三伏，冬補三九\n\t\n\t\t\n\t\t\n\t\t\t一年之中最熱的三伏即將到來\n是中醫預防醫學中「冬病夏治」的好時機\n分別是夏至後的第三個庚日「初伏」\n第四個庚日「中伏」、立秋後第一個庚日「末伏」\t\t\n\t\n\t\n\t\t\t\n\n\t\t\t\n\n\t\t\t「秋分」這天，太陽直射達到180度，使晝夜各12小時，此後，北半球晝短夜長，天氣漸漸轉涼，此時是調整...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t8more老客人梓瑩Janet：「隨著人生一路轉折，我認識到生命就是能量的流動，心胸越開放不執著，就...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t走進市場，白木耳與黑木耳除了名字「黑白」不同，外觀看起來非常相似。你分得清楚兩者有什麼差異呢？...\n\t\t\n\t\t\t\n\n\t\n\t\n\t\n\t\n\n\t\n\n\n\n\n\n\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t客服專線 02-5596-7262 ｜服務時間週一至週五 9:30-12:30/13:30-18:00\n\n\t\t\t©2018 早安健康股份有限公司版權所有，轉載必究 Copyright Everyday Health Co,Ltd All Rights Reserved"],["topImageUrl","https://ftp.pic.everydayhealth.com.tw/edh_upload/website_info/pic_logo_1.png?1475814226"],["error",null]]}]}],["text","(exasperated)比癌更致死！女醫吃1盤保命\nhttps://bit.ly/2rYuN4b\n\n(pencil)飯前吃或飯後吃？水果何時吃，聽聽專家怎麼說\nhttp://bit.ly/28IfypE\n\n(ok)吃好油助代謝！第一道冷壓初榨椰子油可烹飪/油漱/護髮/護膚/護唇安心好用！2件再送椰油皂\nhttps://shop.everydayhealth.com.tw/l.php?1cg50p"],["id","nwroasjharnb"],["createdAt","2018-05-21T04:11:55.016Z"]]}],["reply",{"__iterable":"Map","data":[["id","HNGj5mwBqwaEkHKwtq5E"],["user",{"__iterable":"Map","data":[["id","qTquemUBbZnN2I-Em5wS"],["name","Zzzz"],["avatarUrl","https://www.gravatar.com/avatar/f4fda727ca69d01ed09b0e7e41453fee?s=100&d=identicon&r=g"],["level",15]]}],["type","OPINIONATED"],["text","一、老人髖關節骨折死亡率高是真的，但造成髖關節骨折的不止是骨質疏鬆，體重過重、老人癡呆症和帕金氏症都有可能導致髖關節骨折。\n二、水果應該餐前吃還是餐後吃，其他專家有不同意見，有專家認為與其注意吃的時間點，更應該注意吃的份量，避免吃了水果又吃正餐，結果吃太多。\n三、冷壓椰子油是商品促銷，活動結束現在網頁已經失效。"],["reference","https://tfc-taiwan.org.tw/articles/343\nhttp://www1.wanfang.gov.tw/w402008web_new/subject/download/3100/髖部骨折.HTM"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","【錯誤】媒體報導「飯後馬上吃水果如慢性自殺」？"],["url","https://tfc-taiwan.org.tw/articles/343"],["summary","媒體報導「飯後吃水果如慢性自殺」，經查：\n\n一、醫師和營養師皆表示，任何時段吃水果都可以，但營養師一般會建議可以在餐跟餐中間吃，透過補充健康營養的水果來止嘴饞。\n\n二、與其在意吃水果的時間點，更應該注意控制食量。一般建議每天攝取量為2份，也就是相當於2碗或是2顆拳頭大小的量。\n\n三、報導所述的脹氣、泛酸、便秘等症狀，可能會因為「吃太飽」引起，而並非肇因於「吃水果」。\n部分水果中所含的營養素反而可以幫助飽食後的消化，如：木瓜酵素、鳳梨酵素。而水果中所含有的膳食纖維可以幫助排便，更不可能因為吃水果而導致便秘。\n\n背景\n\n近日媒體報導（如下圖）：「飯後馬上吃水果如慢性自殺！這『時間點』吃最抗癌」，內文引述某健康資訊網站指出，「中國醫學科學院腫瘤醫院營養科副主任劉金英」表示「因為吃了熟食後，體內的白血球會明顯升高，而白血球是為了對付侵入人體的致病菌，但是進食水果後，免疫系統會開啟，長期下來，會降低免疫系統的敏感性，甚至損害免疫系統，不利於防癌抗癌，且吃太飽又吃水果，很可能導致脹氣、泛酸及便秘。」\n\n\n\n查核\n\n爭議點一、報導指稱「吃了熟食後，體內的白血球會明顯升高」是否屬實？\n\n查核中心求證衛生福利部雙和醫院家醫科葉睿儒醫師。葉睿儒表示：這樣的說法不正確，「白血球的生成需要一些時間，它的反應是非常長期的，不會因為吃東西造成體內白血球升高的情況。」\n\n爭議點二、報導指稱「飯後進食水果後，免疫系統會開啟，會降低免疫系統的敏感性，甚至損害免疫系統」是否屬實？\n\n葉睿儒醫師表示，免疫系統本身就不斷在進行身體防禦的工作，「我們的身體並不會因為吃了東西，忽然啟動免疫系統。身體會啟動免疫系統，是這個東西對身體來說有入侵性，才會啟動免疫系統去把它包圍起來。」人體通常處在恆定的狀態，若要產生很大的變化，會需要很長的時間。而腸胃道都有黏膜把食物分隔，不太可能光吃一個東西進去，免疫反應就因此增加或降低。\n\n爭議點三、報導指稱「吃太飽又吃水果，很可能導致脹氣、泛酸及便秘」是否屬實？\n\n查核中心求證財團法人癌症關懷基金會校園營養講師簡鈺樺表示，目前營養學上沒有這樣的說法。會出現脹氣、泛酸、便秘的狀況，可能是因為「吃太飽」，而不是因為「吃水果」。\n\n簡鈺樺說明：「吃太飽造成腸胃道無法完全快速消化而容易囤積，導致脹氣，或是過量的食物全都堆積在胃裡。如此不良的飲食習慣容易導致胃酸逆流而有泛酸感。但部分水果中所含的營養素反而可以幫助飽食後的消化，如：木瓜酵素、鳳梨酵素。」\n\n至於「便秘」的問題，簡鈺樺營養師指出，水果中所含有的膳食纖維可以幫助排便，更不可能因為吃水果而導致便秘。\n\n葉睿儒醫師也認為，報導所述的脹氣、泛酸、便秘等，主要是吃太飽而導致。只要吃過多，就算不是吃水果，而是吃其他食物，也會產生類似的情況。\n\n爭議點四：正餐和水果的食用時間該如何搭配？\n\n（一）簡鈺樺營養師認為，任何時段吃水果都可以，「但營養師一般會建議可以在餐跟餐中間吃，如：早餐和中餐之間或是中餐和晚餐間，由於此時通常是最嘴饞容易亂吃東西的時刻，透過補充健康營養的水果來止嘴饞或是肚子餓的情況，是最合適的。」\n\n但簡鈺樺營養師強調，與其在意吃水果的時間點，更應該注意在「份量」，一般建議每天攝取量為2份，也就是相當於2碗或是2顆拳頭大小的量。若超量了，長期也是會影響身體健康。\n\n（二）葉睿儒醫師也認為，餐後吃水果常見的問題是，因為正餐已經吃很飽，又吃水果會造成進食過多，引發胃部不適、消化不良，長期下來也有肥胖的問題。因此飯後吃水果的重點在於，要控制食量，不要吃過多。\n\n葉睿儒醫師表示，餐前吃水果可以增加飽足感，減少正餐攝取的熱量，可以有減肥的效果；而吃水果可以增加纖維素的攝取。至於吃水果和正餐之間要隔多久，目前在科學上沒有定論。唯一要注意的是糖尿病患，吃水果會讓血糖非常容易上升，因此糖尿病患者吃水果時，建議搭配一些含有蛋白質的食物或是正餐，減少糖份的吸收，盡量讓血糖趨於平緩。\n\n爭議點五：報導引述之「中國醫學科學院腫瘤醫院營養科副主任劉金英」是否真有其人？真有此觀點？\n\n（一）查核中心檢索報導引述之健康類資訊網站，有以「劉金英（中國醫學科學院腫瘤醫院營養科副主任）」之名開設的專欄，在〈奇異果抗癌最夠力！阻斷98％超強致癌物亞硝胺〉文章中有下列內容：\n\n\n\n圖說：健康資訊網站專欄文章擷圖\n\n（二）查核中心前往「中國醫學科學院腫瘤醫院」網站查看（如下圖），營養室頁面沒有呈現工作人員名單，透過關鍵字搜尋「刘金英」，也沒有任何資料。\n\n\n\n查核中心以關鍵字「刘金英」輸入搜尋網站，結果顯示數筆出版資訊，敘述作者是「現任中國醫學科學院腫瘤醫院營養科副主任、營養師。中國營養學會會員、中華醫學會會員、北京中華廚皇協會營養委員會副主任，並取得全國臨床營養專業技術資格證書。」\n\n此外，劉金英營養師在醫療健康網站有固定專欄，以及擔任網路醫療節目的專家來賓，且職稱都是「中國醫學科學院腫瘤醫院營養科副主任」。\n\n\n\n結論\n\n媒體報導「飯後吃水果如慢性自殺」，經台灣事實查核中心求證雙和醫院家醫科葉睿儒醫師，以及癌症關懷基金會校園營養講師簡鈺樺，得知以下訊息:\n\n一、白血球的生成需要一些時間，不會因為吃東西立即造成體內白血球升高，且腸胃道都有黏膜把食物分隔，不太可能光吃一個東西進去，免疫反應就因此增加或降低。\n\n二、醫師和營養師皆表示，報導所述的脹氣、泛酸、便秘等症狀，可能會因為飲食習慣不良或「吃太飽」引起，而並非肇因於「吃水果」。\n部分水果中所含的營養素反而可以幫助飽食後的消化，如：木瓜酵素、鳳梨酵素。而水果中所含有的膳食纖維可以幫助排便，更不可能因為吃水果而導致便秘。\n\n三、任何時段吃水果都可以，但營養師一般會建議可以在餐跟餐中間吃，透過補充健康營養的水果來止嘴饞。但與其在意吃水果的時間點，更應該注意控制食量。一般建議每天攝取量為2份，也就是相當於2碗或是2顆拳頭大小的量。\n\n因此，「飯後馬上吃水果如慢性自殺」為「錯誤」訊息。"],["topImageUrl","https://tfc-taiwan.org.tw/sites/default/files/upload/node/field_blog_images/fruit%26meal_01_new.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","髖部骨折"],["url","http://www1.wanfang.gov.tw/w402008web_new/subject/download/3100/髖部骨折.HTM"],["summary","髖部骨折：常見的老人意外傷害\n\n\n臺北市立萬芳醫院 \n 骨科主治醫師 \n莊太元醫師\n\n\n 隨國內老年人口的增加，在年紀超過五、 \n六十歲的族群中，只要稍不留心，摔倒之後，就很容易發生骨折。而其中以髖關節的骨折最為常見，女性的發生率約為男性的二至三倍。此外，體重過重、老人癡呆症和帕金氏症，也都是造成髖部骨折的危險因子。而且，目前大家關心的骨質疏鬆症，也會增加骨折的發生率。\n\n\n \n\n90﹪以上的髖部骨折是因為跌倒而發生，其他包括交通意外、高處墜落等，也會造成骨折。因此，一個安全的環境，對於防止髖部骨折甚為重要.日常生活中常發生的地方，譬如廚房、浴室、階梯等處，都必須加裝一些防護措施。如防滑地毯，或是扶手等。\n\n\n \n一但發生髖部骨折，大部分病人會感到劇烈疼痛，無法行走，甚至在床上翻身或移動時，也會劇痛難當。依據統計，老人髖部骨折，如果未經適當治療，一年內的死亡率，可以達到20﹪以上。因此，如果老人發生跌倒後無法站立、疼痛的病狀，應就近至醫療院所的急診室骨科或外傷科診治。絕大部分的髖部骨折都需要手術治療。\n\n\n \n老人髖部骨折的治療，通常必須先作完整術前詳細的評估後，再實行手術。老人的骨折，手術前身體狀況的評估相當重要，包括糖尿病、高血壓、心臟病…等，必須多加注意之外，更必須注意病人的肝功能、腎功能、營養狀況、和受傷前活動的程度…等等。這類手術雖然對骨科專科醫師而言，是常見而不複雜的手術，但是病人的年紀加上內科疾病，反而是非常重要課題。因此，內科醫師的配合診治, \n也是成功治療的關鍵。\n\n\n \n髖部骨折在骨科的專業領域上，分為股骨頸骨折、股骨轉子間骨折、和股骨轉子下骨折。手術治療必須使用鋼釘固定，或是人工關節換置，可以立刻改善病人生活品質，並降低死亡率。\n\n\n \n不論做復位固定或是人工關節換置手術，大部分這類的手術可在半身麻醉下,一至二小時內完成。若病人無其他疾病，於恢復室半個小時至一個小時觀察後，即可回到病房。手術後若放置引流管, \n也可在第二到第三天拔除; 大部分的病人也可以在術後第二天開始使用助行器練習行走，並配合股四頭肌的復健訓練。若沒有其他合併症的發生, \n病人可在術後第四天或第五天出院。出院後的門診追蹤，起初的三個月, 每個月觀察傷口並追蹤X光片,\n觀察有無內固定鬆脫和骨折癒合的程度等等.\n此外,也可以開始使用骨質疏鬆的藥物，包括抑鈣激素,荷爾蒙類藥物, \n或是磷酸鹽類藥物等配合鈣片的治療. 其中, 骨折約需三個月到半年骨折才會癒合. 而骨質疏鬆的治療約壹至貳年。\n\n\n \n髖部骨折，決不僅是單純的骨骼斷裂，更應視為老人疾病的一種。因此，除治療骨折及骨質疏鬆之外，更應綜合評估老年人生理及心裡狀態。此外家屬的配合及後續的復健治療，也是治療成功的關鍵。而一般日常生活的防護，更是促進老年人健康及生活品質的不二法門。"],["topImageUrl",""],["error",null]]}]}],["createdAt","2019-08-31T07:46:24.457Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_iwVjDjINyiDpn7RbTFqTWf6CzdOxSJbasBOvvyiFAaM"],["name","令人信服的竹北南茜"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","早安健康｜黑木耳4大養生功效！超級食材黑木耳助減肥抗癌"],["url","http://bit.ly/2aXlVTW"],["summary","【早安健康／林姿彣整理編輯】黑木耳有「養生萬靈丹」美稱，有鈣質、鐵質、維生素等豐富營養，其實也是超級減肥食材！到底黑木耳的功效有哪些？富含哪些營養帶來養生效果呢？\n黑木耳營養價值\n\n\n 維生素B2\n 鈣質\n 鐵質\n\n「人不可貌相」這句話很適合用在黑木耳上，黑木耳雖然沒有吸引人的外表，但是內在卻富含各種驚人的營養素，像是它的維生素B2含量，是米、麵和大白菜的10倍，鈣含量也是肉類的30～70倍，鐵質更是肉類的100倍之多！\n黑木耳是減肥好食材！\n\n 低熱量\n 富含纖維質\n 容易有飽足感\n 植物性膠質\n黑木耳最大的特色是可以作為減肥的天然食品！因為黑木耳熱量低、富含纖維質，可減少食物攝取量，吃下去容易有飽足感，能達到減重效果；此外，黑木耳是植物性膠質，所以能夠隨著腸胃蠕動，附著在胃壁和腸道上，減緩胃腸酵素分泌到腸胃中，進而降低飢餓感。\n黑木耳富含膳食纖維改善便秘\n\n對於外食族而言，黑木耳有一個很重要的好處，那就是它含有豐富的膳食纖維！根據長庚醫院營養治療科團隊合著的《營養師教你跟著四季吃健康》，每100克黑木耳就含有6.5克的膳食纖維，與我們耳熟能詳高營養價值的蔬菜相比（如高麗菜1.3克、空心菜2.1克、花椰菜2.2克、菠菜2.4克、地瓜葉3.1克），黑木耳顯然是大富翁！因此，多吃黑木耳，非常有益於腸胃蠕動、消解便秘。食材膳食纖維比一比：黑木耳膳食纖維多\n\n \n \n 食材\n 膳食纖維(每100克)\n \n \n 黑木耳\n 6.5克\n \n \n 地瓜葉\n 3.1克\n \n \n 花椰菜\n 2.2克\n \n \n 空心菜\n 2.1克\n \n \n 高麗菜\n 1.3克\n \n \n 菠菜\n 2.4克\n \n \n\n養生食材：黑木耳，鐵鈣雙全，清血管清腸道！\n\n \n\n\n研究：黑木耳入中藥改善肥胖\n事實上，黑木耳的減重效果，蠻早就被發現。長期研究黑木耳的南台科大生技所教授陳啟楨，在2005年的實驗中，發現將黑木耳加入中藥裡，可以有效改善肥胖者的神經、內分泌、消化等系統，進而降低肥胖者食慾，達到減重效果。所以，趕快多吃一點黑木耳吧！ \n黑木耳養顏美容\n \n要是因為木耳黑黑的，就認為它不具有養顏美容的效果的話，那你可就大錯特錯了！在2009年時就已經有研究顯示，如果連續4週，塗抹含0.5％的黑木耳萃取物乳霜，能夠有效提高皮膚含水率，而且相較於未使用者，有使用的人皮膚較白，這表示黑木耳可以降低黑色素沉澱。 \n \n【延伸閱讀】\n\n 黑木耳好處多！料理達人教你用電鍋自製黑木耳露\n 不花大錢買補品！抗癌美食家教你用木耳養生\n 補充膠原蛋白！電鍋就能做出水果白木耳甜湯\n 在家自製天然補品！用電鍋就能煮出超營養黑木耳露\n 4大黃金排毒食材！黑木耳富含纖維、地瓜葉促糖代謝"],["topImageUrl","https://farm9.staticflickr.com/8788/28471575220_4ff8ae2c4a_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康｜腰痛快躺平、穿護腰？日醫：反而拖更久，這樣最快好"],["url","https://bit.ly/2kaEPfi"],["summary","【早安健康／張承宇報導】多數人都曾受到腰痛的困擾，原因卻常常「無知影」，問街坊鄰居，他們總是說：閃到腰？穿護腰、多多休息、貼個撒隆巴斯幾天仔就好啊啦！」，但其實，東京大學醫學部附屬醫院特任教授松平浩指出：我們以往應對腰痛的方式其實都錯了！這樣只會讓我們腰痛好得更慢，甚至更加嚴重。\n \n其實，腰痛的真正原因很難判斷，透過MRI核磁共振攝影、X光攝影可以診斷出的腰痛大約只有15％，剩下的85％原因較難釐清。\n腰痛的原因\n\n腰痛的原因有很多，松平醫師概略將腰痛的原因分成三種，並表示：腰痛先不用太過擔心，剩下的85％只要正確應對，通常不會造成太大的危害。\n\n 紅色燈號骨折、重大疾病或是神經症狀（脊柱管狹窄症、椎間盤突出症等），務必第一時間接受治療。\n 黃色燈號以為馬上會好卻持續很久的腰痛，此類腰痛其實可以快速痊癒，會造成較大影響的原因通常是患者對腰痛的不安、恐懼、壓力等心理因素，導致無法迅速恢復健康。\n 綠色燈號閃到腰等一般常見的腰痛。\n\n其中只有紅色燈號是因為明確原因造成腰痛，黃色及綠色燈號都是屬於不會造成太大危害的其他85％。\n腰痛難以痊癒？恐是心理因素導致\n \n日本針對腰痛者進行調查，結果顯示：\n\n 在腰痛後完全休息靜養的患者，腰痛時間持續3個月以上的約28.6%。\n 在腰痛後，進行和緩而可以忍受的腰部運動的人，腰痛持續3個月以上的，是0。\n\n換言之，腰痛後完全不動，竟然讓腰痛持續的時間更長。松平醫師指出，這是因為我們腰痛時產生「怎麼辦」、「腰痛怎麼還沒好啊？」諸如此類不安、恐懼的心理，會讓大腦過度反應，變得害怕疼痛而只敢安靜休養，腰部卻也因此分泌疼痛物質，造成惡性循環。\n\n\n正確抗腰痛的方式下一頁告訴您！"],["topImageUrl","https://c1.staticflickr.com/1/945/41818624942_92074e2ba2_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康嚴選"],["url","https://shop.everydayhealth.com.tw/l.php?1cfpkq"],["summary","【九月慶中秋】親友相聚送禮表心意，滿額再加贈超值好禮\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\t\t●●●●●●●●●●●●●●●●\t\t\t\t\t\n\n\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\n\t\t\n\n\n\n\n\n個資安全加密\nSSL憑證安全付款 \n\n\n\n \n\n購物滿1200元\n整筆訂單免運費 \n\n\n\n \n\n加入LINE好友\n立即現折100元 \n\n\n\n \n\n立即來電訂購 \n02-5596-7262\n\t\n\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\n\t\t\t\t\n\t\t\n\n\t\t\t\n\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tAmericanTraveler 20吋超輕量抗刮行李箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\n\t\n\t\t\n\t頭皮護理手札：為什麼洗頭髮要洗兩次？\n\t\n\t\t\n\t\t\n\t\t\t「夏季要一天洗幾次頭才夠呢？頭髮多只要一流汗頭皮癢，洗完還是悶悶的！」\n「每天都要戴著安全帽騎車通勤，長久下來頭皮長痘痘了，該怎辦呢？」\t\t\n\t\n\t\n\t\t\t\n\n\t\t\t\n\n\t\t\t「秋分」這天，太陽直射達到180度，使晝夜各12小時，此後，北半球晝短夜長，天氣漸漸轉涼，此時是調整...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t🌝【全館慶中秋9/1~9/30】月圓不圓圓，雙重獻禮送健康🌛全館消費滿額免費送鬆筋按摩器(市價399...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t8more老客人梓瑩Janet：「隨著人生一路轉折，我認識到生命就是能量的流動，心胸越開放不執著，就...\n\t\t\n\t\t\t\n\n\t\n\t\n\t\n\t\n\n\t\n\n\n\n\n\n\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t客服專線 02-5596-7262 ｜服務時間週一至週五 9:30-12:30/13:30-18:00\n\n\t\t\t©2018 早安健康股份有限公司版權所有，轉載必究 Copyright Everyday Health Co,Ltd All Rights Reserved"],["topImageUrl","https://ftp.pic.everydayhealth.com.tw/edh_upload/website_info/pic_logo_1.png?1475814226"],["error",null]]}]}],["text","(crown)比菠菜地瓜葉厲害！抗癌減重的超級食物不能錯過它\nhttp://bit.ly/2aXlVTW\n\n(frozen)腰痛躺平、穿護腰？日醫：反而拖更久，這樣最快好\nhttps://bit.ly/2kaEPfi\n\n(3 hearts)吃好油身體最知道，嚴選台灣苦茶油含茶多酚、維生素A、E、不飽和脂肪酸，烹飪直接飲用皆宜！2瓶限時9折\nhttps://shop.everydayhealth.com.tw/l.php?1cfpkq"],["id","1pwywvl7ymqxo"],["createdAt","2018-05-19T14:06:43.775Z"]]}],["reply",{"__iterable":"Map","data":[["id","FR73eGMBSH_MLFhIMmMI"],["user",{"__iterable":"Map","data":[["id","AVriAlOoyrDaTqlmmqhC"],["name","Lin"],["avatarUrl",null],["level",22]]}],["type","RUMOR"],["text","如果要靠吃黑木耳產生療效，吃的量應該要非常大。有些人可能對黑木耳中這種成份有微量的效果，需視個人體質，但一般而言對效果應該不大。"],["reference","https://www.nownews.com/news/20091125/783051\n木耳良方？"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","找不到與「 News 20091125 783051」相關的文章或頁面"],["url","https://www.nownews.com/news/20091125/783051"],["summary","為了提供更好的閱讀內容，我們使用相關網站技術來改善\n使用者體驗，也尊重用戶的隱私權，特別提出說明。 OK"],["topImageUrl","https://www.nownews.com/wp-content/uploads/2018/09/1536552202-c889e8c0b59eca0fca0c2a89ccbca345.png"],["error",null]]}]}],["createdAt","2018-05-19T15:14:16.204Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_3030n4skqr0Wh7bQkJbP8gSoRVyvOsNfLVGQo4zWrbs"],["name","一本正經的琉球芝妮雅"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","不再是老年人才會罹患！如何預防突發的心肌梗塞？｜周孫立醫師｜健康連線｜早安健康"],["url","https://bit.ly/2Dz1bSs"],["summary","被稱作無形殺手的「心肌梗塞」一發作，彷彿在跟死神拔河！資深藝人馬如風、戎祥、茂伯、馬兆駿、小北百貨創辦人黃卜文、親民黨前立委馮定國等，皆因心肌梗塞而離世。最近季節交替，因溫差大，像近日早晚較有涼意，中午較高溫，有時不注意，也可能會有心肌梗塞的風險。究竟為什麼會發生心肌梗塞？又該注意什麼呢？周孫立醫師說明，通常造成心肌梗塞的原因是不會突然發生、出現的，大部分人都是因為長期不良的先天條件、不良的後天環境及不良的個人習慣造成。心肌梗塞的高危險群？\n\n有高血脂、高血壓家族病史周孫立醫師說，由於現今外在環境汙染等問題很多，就容易讓原來先天存在不良的體質，提早誘發問題，所以才會有漸趨年輕化的現象。若是發現自己的家族有相關心血管疾病的遺傳因子，就要特別注意。\n三高（高血糖、高血脂、高血壓）患者代謝及血管功能失調也是導致心肌梗塞的危險因子。\n慢性腎臟病\n先天心臟功能不全\n心臟傳導異常\n腦血管疾病，或身體其他各處血管疾病\n\n\n心肌梗塞有前兆嗎？\n周孫立醫師指出，心肌梗塞從過去至今的死亡率都很高，原因就是表現出來的症狀都不太明顯或不太專一，最常見的症狀為「胸痛」，但也有很多患者是出現其他症狀，導致錯失警訊，因此延誤就醫。此外，在某些神經功能退化的人，尤其是老人家，甚至沒有症狀。心肌梗塞症狀\n\n胸痛（大部分）\n肩膀痠痛\n牙齒痛\n胃痛\n脖子痠痛\n背痛\n呼吸短促\n未出現症狀\n\n突發心肌梗塞怎麼辦？如何治療？下一頁看醫師詳解"],["topImageUrl","https://c1.staticflickr.com/5/4821/31009133877_d75822c48c_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康｜運動前喝一杯，多減17％內臟脂肪！"],["url","https://bit.ly/2byK1YY"],["summary","【早安健康／健談】茶飲是非常常見的飲品種類之一，健爺爺每天飯後都要喝杯茶才滿足！你知道\n喝綠茶的好處有哪些嗎？快來看看吧～ \n \n \n \n1. 綠茶有助減少體脂肪 \n綠茶中含有茶多酚、兒茶素、維生素C等，有助脂肪氧化，配合飲食與運動可有效達到降脂減肥的效果。研究指出，運動前喝綠茶，能多消耗17%的體脂肪，增加運動燃脂的效果。 \n \n \n2. 綠茶能抗氧化、延緩老化 \n茶葉中的抗氧化物質EGCG可中和身體內的自由基，達到延緩老化的作用。 \n \n \n3. 綠茶有助防癌 \n綠茶中高含量的多酚可以幫助清除自由基，預防癌症。 \n \n \n4. 綠茶能抵抗輻射傷害 \n綠茶中的維生素C、兒茶素有助降低紫外線或3C用品的輻射傷害，且綠茶中的維生素A也可保護視力，預防眼睛傷害。 \n \n \n5. 綠茶有提神效果 \n綠茶中的多酚與兒茶素，有助快速恢復精神，達到提神醒腦的效果。 \n \n \n6. 綠茶能延緩骨質流失 \n研究發現，停經婦女每日攝取4~6杯茶有助延緩骨質流失，尤其喝茶時間長達10年以上者，骨質密度明顯比不喝茶者來得高。 \n \n \n7. 綠茶能降低蛀牙機率 \n茶葉中含氟、兒茶素，可減少細菌附著在齒面或停留於口腔中，降低蛀牙的機會。 \n \n茶對健康有益，但應適量攝取才能發揮最大效果，建議可在飯後喝避免刺激腸胃。另外，有特殊疾病者建議先詢問醫師或營養師適當的飲用方式。 \n \n圖文創作：健談 \n專家諮詢：高雄市立鳳山醫院營養治療科廖嘉音營養師 \n \n作者簡介：\n健談用健康漫畫方式，帶你簡單瞭解正確健康概念與疾病，讓大家一起漫漫健康～想看每日最新健康資訊嗎？請上 \n健談粉絲團\n\n綠茶還有更多健康好處，下一頁繼續看更多！"],["topImageUrl","https://farm9.staticflickr.com/8440/28395715994_80e30138d6_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康嚴選"],["url","https://shop.everydayhealth.com.tw/l-fe4cw8"],["summary","●●●●●●●●●●●●●●●●\t\t\t\t\t\n\n\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\n\t\t\n\n\n\n\n\n個資安全加密\nSSL憑證安全付款 \n\n\n\n \n\n購物滿1200元\n整筆訂單免運費 \n\n\n\n \n\n加入LINE好友\n立即現折100元 \n\n\n\n \n\n立即來電訂購 \n02-5596-7262\n\t\n\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\n\t\t\t\t\n\t\t\n\n\t\t\t\t\n\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【淨毒五郎】洗衣槽抗菌清潔劑3盒★抗菌防黴、深層去汙、天然環保\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tAmerican Traveler輕量20吋行李箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【強生】全能訓練椅CS-8606 (期間限定送訓練海報+電鍍啞鈴2kg/組)\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【Muva】美姿骨盤枕★限時加購【Muva】超彈力瑜珈墊(魅力桃)\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tFun Sport協調鍛鍊免運組-美肌塑體神拉器+Q彈有氧啞鈴\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\n\t\n\t\t\n\t金平風味椰子油炒鮮菇～省時美味料理\n\t\n\t\t\n\t\t\n\t\t\t一年四季都適合端上桌的快手料理。備料迅速、不會花太多時間，滋味香醇潤口，忙碌的時候也能好好上菜，可說是煮婦的超級好隊友。\t\t\n\t\n\t\n\t\t\t\n\n\t\t\t\n\n\t\t\t「鹽麴」是米麴、鹽、水發酵熟成的調味料，發酵的過程令鹽麴的味道多了像清酒的香氣，卻沒有酒精成份。三百...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t髮質好不好除了遺傳因素和營養因素等等的原因之外，後期的頭皮養護也是關鍵！你的日常頭皮養護做對了嗎?　...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t國曆10月23-24日是秋天的最後一個節氣─霜降。在台灣可以明顯看見樹葉轉黃，也是賞菊的好時機；氣溫...\n\t\t\n\t\t\t\n\n\t\n\t\n\t\n\t\n\n\t\n\n\n\n\n\n\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t客服專線 02-5596-7262 ｜服務時間週一至週五 9:30-18:00(12:30午休1h)\n\n\t\t\t©2019 早安健康股份有限公司版權所有，轉載必究 Copyright Everyday Health Co,Ltd All Rights Reserved"],["topImageUrl","https://ftp.pic.everydayhealth.com.tw/edh_upload/website_info/pic_logo_1.png?1475814226"],["error",null]]}]}],["text","(oh no!)4位藝人這病走了！名醫：3種食物少吃... \nhttps://bit.ly/2Dz1bSs\n\n(love)運動前喝一杯，多減17％內臟脂肪！\nhttps://bit.ly/2byK1YY\n\n(tulip)財富自由、健康到老，打造無憂人生下半場！一天不到10元，訂早安健康一年12期+今周刊一年52期加送雙好禮超值合購熱賣中！\nhttps://shop.everydayhealth.com.tw/l-fe4cw8"],["id","1fn23e8mzk1rs"],["createdAt","2019-11-07T02:26:41.996Z"]]}],["reply",{"__iterable":"Map","data":[["id","mVbI-m4BV0DITCqGEWK0"],["user",{"__iterable":"Map","data":[["id","4NN2_GwBqwaEkHKw4whM"],["name","Lora"],["avatarUrl","https://www.gravatar.com/avatar/?s=100&d=mp"],["level",9]]}],["type","RUMOR"],["text","首先，見下面連結了解更多心肌梗塞注意事項。\n再來，喝茶的確有好處，但也有需要注意的地方，成大醫院家醫部社區醫學科主任楊宜青：「有下列情況的人則不合適長期喝茶。例如，對咖啡因敏感的人，喝茶會有心悸、手抖和失眠等不良反應。有腸胃疾病的人，如消化性潰瘍、胃發炎、習慣性腹瀉等。」\n\n第三個連結為廣告"],["reference","https://www.ihealth.com.tw/article/%E5%BF%83%E8%82%8C%E6%A2%97%E5%A1%9E/\nhttps://www.cw.com.tw/article/article.action?id=5005107"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","心肌梗塞有這些前兆！預防心肌梗塞記住這5招"],["url","https://www.ihealth.com.tw/article/%E5%BF%83%E8%82%8C%E6%A2%97%E5%A1%9E/"],["summary","•短訊息我以為一定要親自回醫院才能領到一樣的藥，原來送藥到府也可以。根據衛福部公布的2017年國人十大死因統計，心臟疾病排名第二，其中心肌梗塞（冠狀動脈心臟病之一）更是奪命主要元兇。本文重點心肌梗塞原因發作前兆高危險族群預防原則心肌梗塞發作時機正確自救法治療方式為什麼會發生心肌梗塞？冠狀動脈是輸送養分與氧氣給心臟的重要角色，心臟表面共有三條冠狀動脈圍繞，若是任何一條因為發生粥樣硬化（血管內堆積脂肪等異物），使血管失去彈性、管壁內部變厚變硬，血管就可能因為變窄而發生阻塞。一旦血管受阻，心臟便會缺氧、缺血而引發不適症狀，當心臟肌肉因此損傷時，就稱為心肌梗塞。注意這些發作前兆！典型的心肌梗塞症狀包括：左胸胸痛或胸悶（自覺心臟受到擠壓）呼吸急促或困難頭昏眼花噁心不適除此之外，患者可能發生的症狀還有胸腔膨脹感，或是手臂、脖子、背部、上下顎等處感到疼痛。當以上症狀發生時，應儘速就醫。值得留意的是，患者有時會以為胸口疼痛是胃食道逆流造成的「火燒心」，偏偏兩種病症的患者皆有抽菸的習慣，若未進一步就醫，往往會錯失醫治良機。這些高危險群要當心！根據國民健康署資料顯示，有下列危險因子者，發生心肌梗塞的機率較高，需要更加留意自身健康狀況。高血壓高血壓患者比一般人多出2.5倍機率罹患心臟病。所謂高血壓，就是在休息狀況下血壓持續高於140（收縮壓）／90（舒張壓）mmHg。一般血壓值應小於120 （收縮壓）／80（舒張壓）mmHg。糖尿病糖尿病患者罹患心臟病的機率也高出一般人2倍，而且患者比起常人更不容易發現心臟病帶來的疼痛感，應更加留意。常人的糖化血色素為4-6%，而糖尿病患者應控制在7%以下。高血脂症體內過多的膽固醇會累積在血管內，使血管管徑縮小，動脈因而更容易發生硬化或阻塞。然而，在所有膽固醇中，「低密度膽固醇 (LDL)」會造成血管堵塞，一般建議應低於130mg/dl。肥胖症因為肥胖會引發以上症狀，而這些疾病又是心臟病的高風險因子。癮君子香菸中的尼古丁會損害心臟血管。家族病史家族遺傳基因可能是造成心肌梗塞的原因之一。更年期後的女性更年期後的女性，體內雌激素分泌降低，亦提高心血管疾病的發生率。缺乏運動者血液中的高密度膽固醇 (HDL) 有助於清除血管中堆積的脂肪，然而缺乏運動者，其高密度膽固醇濃度較低。濫用藥物如安非他命 (amphetamine)，它會刺激交感神經系統，影響正常血壓狀態，提高動脈粥狀硬化的風險，而古柯鹼 (cocaine) 則可能引起血栓形成或冠狀動脈痙攣等不利心臟的結果。預防心肌梗塞牢記這五點根據國民健康署的建議，下列方法有助於降低心肌梗塞的發生率：（一）拒菸不管是直接吸入或是二手菸，都會增加心臟病的患病風險；戒菸一年後，罹患冠狀動脈心臟病機率可降低5成。（二）改變飲食習慣挑選低鈉飲食以控制血壓，並選用天然植物油，多吃蔬果、堅果、糙米類等食物。（至於怎麼吃得更健康，請參考控制高血壓，得舒飲食六撇步）（三）規律運動至少每週三次，每次30分鐘的中度身體活動，走路、慢跑、騎自行車都是不錯的選擇。（四）積極控制三高針對高血壓、高血糖、高血脂狀況，如需服藥，應遵照醫生指示，並定期回診追蹤。（五）健康檢查為了早日發現心臟病潛在因子，國人可利用國民健康署提供的40到64歲民眾每三年一次，65歲以上民眾每年一次的免費成人預防保健服務。小心！以下情況容易引發心肌梗塞運動或提重物時若平常沒有運動習慣，突然提重物或進行激烈運動，心臟恐怕無法負擔。飽餐之後此時，身體的血液大量分配到消化系統，若冠狀動脈已發生堵塞，將無法輸送足夠的血液到達心臟。在很冷或濕熱的天氣外出極端氣候會增加心血管疾病的發生機率。壓力太大、情緒起伏變化激烈情緒變化激烈（如受到驚嚇）將會影響正常血壓狀態，久則不利心臟運作。聽說咳嗽是心肌梗塞自救法，真的嗎？為了對抗心肌梗塞，網路上流傳一套自救法，當出現心肌梗塞徵兆時，只要大力咳嗽，就可擠壓、按摩心臟，提升存活率？然而，這種說法已被美國心臟協會 (American Heart Association, AHA) 與英國心臟基金會 (British Heart Foundation, BHF) 駁斥為謠言，兩個組織的專家認為，大力咳嗽不但無法自救，甚至會使患者延誤送醫，錯過黃金治療期。★最好的救援方法還是在喪失意識前，盡可能平躺在地，以防後續摔傷，並找到離自己最近的人，請他撥打119，請專業人員協助送醫。治療方式：把握黃金12小時當患者出現心肌梗塞相關症狀時，應把握黃金12小時救治期，到院完成心電圖等相關檢驗，再由醫師決定採取以何種方式重新「打通血管」。方法一：心導管介入性治療在侵入性治療方面，現行有到院90分鐘內實施心導管支架或氣球擴張術，目的是為了撐開受阻的血管，使血流回復。若阻塞情況嚴重，醫師甚至會為患者施行冠狀動脈繞道手術，由身體其他部位擷取血管（如腿部靜脈、內乳動脈等）接至心臟，繞開阻塞部位，為血流「開道」。另外，有些醫院未必有足夠設備為患者施行侵入性治療，若無法在120分鐘內轉診實施手術，醫師也可能視情況為病人先施打 r-tPA（血栓溶解劑）。方法二：藥物治療藥物方面，主要目的是以降低血栓再次形成為主，可分為：抗血小板製劑例如阿斯匹靈 (Aspirin)、醣蛋白 IIb/IIIa 複合物 (Glycoprotein (GP) IIb/IIIa antagonists)、保栓通膜衣錠 (Clopidogrel)、百無凝膜衣錠 (Ticagrelor) 等等，這類藥物能避免血小板凝集產生血塊，造成血管再一次發生堵塞狀況。貝它阻斷劑 (Beta-blockers)可使心跳減緩、心肌收縮力下降，使心臟降低對氧氣的需求，但有急性心臟衰竭、心因性休克、心搏過緩、或活動性氣喘則不能用。史他汀類 (Statins)為降血脂藥物，由於心肌梗塞與高血脂有關，故此類藥物亦可用以對抗該疾病。ACEI 或 ARB 藥物血管收縮素轉換酵素抑制劑 (ACEI) 可以改善患者的血壓異常及心臟衰竭狀態，卻會伴隨咳嗽的副作用，醫生也會視情況改用血管收縮素受體阻斷劑 (ARB)。抗血栓藥劑抗血栓藥劑 (unfractionated heparin) 簡稱 UFH，此類藥物以靜脈注射為主，降低血栓形成機率。由於抽菸、壓力大，動得少、吃得卻多等情況，現代人不知不覺間將自己暴露在心臟病的攻擊範圍內。為避免患病，以下將為您介紹幾招護心心法。現在，正是起身行動的時候了！正視心肌梗塞，謹記以上護心心法，別讓心痛淪為心慟！ •短訊息原來送藥到府已經服務10年了，而且竟然是零元也可以使用。參考資料：衛福部國民健康署、衛福部國民健康署、全球心肌梗塞照護網、中華民國防高血壓協會、Understanding Heart Attack ─ the Basics、AHA、BHF \n \n 加入好友，即時掌握健康訊息"],["topImageUrl","https://i2.wp.com/www.ihealth.com.tw/article/wp-content/uploads/2017/06/心肌梗塞FB1封面.png?fit=1200%2C630&ssl=1"],["error",null]]},{"__iterable":"Map","data":[["title",null],["url","https://www.cw.com.tw/article/article.action?id=5005107"],["summary",null],["topImageUrl",null],["error","NOT_REACHABLE"]]}]}],["createdAt","2019-12-12T15:44:06.081Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_6X-TIb4UI-5haLAzcNp68YXmc2ZZXbeYHt79kLVtuUQ"],["name","正直無私的東引李維"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","早安健康｜老是睡不飽？試試這個姿勢，10分鐘等於休息3小時！"],["url","https://bit.ly/2fyQdir"],["summary","【早安健康編輯部／編譯】每天忙碌的生活中，許多人給自己唯一的休息時間就是睡眠，最常見的是以睡眠時間為指標，希望每天可以睡滿6～8小時，讓身體得到充足休息。 \n然而你可能也發現，在加班、應酬和其他活動瓜分之下，要睡滿8小時實在太困難了！即便做到，也不見得隔天醒來就精神飽滿。我們經常掛在嘴邊的「怎麼睡都睡不飽」，指的其實就是這種睡眠時間不等於休息品質的情形。 \n日本睡眠醫學博士坪田聰於著作中指出，一旦睡眠品質不佳，體內的生長荷爾蒙就無法成功修復細胞、消除疲勞，例如100個受損細胞裡面，只成功修復或再生其中50個細胞，久而久之不僅會提早老化，生病的風險也會提高。 \n \n日本Lapure瑜伽中心指導講師森初世以自身經驗指出，現代人生活忙碌，尤其是30～40歲女性想要維持美麗與健康，更要把握僅存的夜晚時間，最有效率地達到放鬆與休息的目的，擺脫睡眠不足、睡眠品質不佳的困擾。 \n想要在有限的時間裡完全放鬆，不妨嘗試瑜伽姿勢「大休息」（SAVASANA，又名「攤屍式」）。森初世表示，只要維持整個人平躺的「大休息」姿勢10分鐘，就能達到平常休息2～3小時的效果，是短時間內迅速恢復體力的首選！ \n森初世也建議，進行「大休息」時要盡量讓頭部、眼睛、肩膀、指尖等身體各部位放鬆，同時想像全身不斷往下沉，直到緊貼地面。另外，事先將室內燈光調暗，有助於放鬆心情，也可以準備薄毛毯保暖，避免感冒。 \n瑜伽「大休息」姿勢這樣做＞＞ \n1. 仰躺，雙手置於身體兩側，手心朝上，雙腳打開與骨盆同寬。2. 閉上眼、緩緩呼吸，維持10分鐘。 \n森初世認為，進行「大休息」時，最理想的是維持在快要睡著卻沒有睡著的朦朧狀態，但是太舒服而睡著了也沒有關係。因為瑜伽「大休息」姿勢不僅能消除一整天的疲勞，也有助於進入熟睡狀態、增進睡眠品質。 \n下回覺得睡不飽時，無論是想要短時間恢復精神，或是睡前助眠，都不妨試試這個簡單的姿勢，短短10分鐘就可以睡得健康又美麗。【同場加映】老是睡不飽、常脹氣都是肝臟求救訊號！多吃4類食物養好肝早上起不來？白天曬太陽、傍晚動一動，3招讓睡眠更有效率練核心！只要一個動作，擺脫小腹粗大腿"],["topImageUrl","https://farm6.staticflickr.com/5718/22717634527_ff87853145_b.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","早安健康嚴選"],["url","https://shop.everydayhealth.com.tw/l-1dnp8g"],["summary","關於早安健康嚴選\t\t \n\t\t常見問題聯繫我們登入/註冊\t\n\n\n\n\n\t\n\t\t\n\t\t\t\t\t\n\t\t\n\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t免運防蚊拉筋板\n\n\t\t\t\n\t\t\n\t\t\t\t\n\t\t\t 0 個商品\t\t\t\n\t\t\n\t\n\n\n\n\n\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t嚴選推薦運動塑身健康飲食生活良品雜誌熱門專欄\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\n\t\t\t\t\t\n\n\n\n\n\n\n\n\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\n\t\t\n\t\t\t\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t【挑戰年底最低價】花蓮立閣人文旅店超值住宿優惠再送早安健康一年份\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\t\t●●●●●●●●●●●●●●●●\t\t\t\t\t\n\n\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t購物金改制\n\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tLINE好友獨享\n\t\t\t\t\t\n\n\t\t\t\t\n\t\t\t\n\t\t\n\t\t\n\n\n\n\n\n個資安全加密\nSSL憑證安全付款 \n\n\n\n \n\n購物滿1200元\n整筆訂單免運費 \n\n\n\n \n\n加入LINE好友\n立即現折100元 \n\n\n\n \n\n立即來電訂購 \n02-5596-7262\n\t\n\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【昌豐】日本原裝唐辛子保健貼布(2入)\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$89 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【muva】美姿骨盤枕★日本骨盤瘦身達人推薦！\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$1,380 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【萃綠】檸檬果膠代謝酵素750ml\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$1,580 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t金笛柚子醋醬油150ml\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$200\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【順天堂】溫心好薑★原薑切片真材實料\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$150\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【順天堂】珍品枸杞王★市售唯一入藥典品種，品質超群\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$240 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【薌園】黑芝麻粉350g\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$180\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【Fun Sport】纖腰扭扭盤-足按摩款 (轉盤/腰扭盤/扭腰盤/妞妞盤)\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$699 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【萃綠】檸檬酵素精萃液(20mlx12瓶)\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$1,200 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【果物配】台灣酪梨-友善農法(濃郁滑順．超大顆/3公斤)★CP值超高，好大一顆梨！\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$749 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【超值免運組】金笛再釀造生醬油+柚子醋醬油\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$800\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【薌園】燕麥糙米豆漿32g x 12入\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$145\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【特級草莓禮盒】有機(轉)《送禮最大器．每箱40入》\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$899 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【居家檢測】水保鏢–水質檢測2入\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$1,500 組合價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【生態綠】100%純可可粉*1+純黑巧克力片*5\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$1,200 組合價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【薌園】紅豆紅薏仁粉500g\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$380\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【智利櫻桃】空運直送《深紅大顆超過癮 /1公斤》\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$899 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t【食在加分】Brown Sweetie手工柴燒黑糖立袋(3袋組)\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$576 組合價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t《早安健康》一年12期 + Pockeat大食袋(3L)\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$1,480 促銷價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t可可威達初榨椰子油443ml+生態綠純黑即溶咖啡30入\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t$820 組合價\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t搶購\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\n\t\t\t\t\t\n\t\t\t\t\n\n\t\t\t\t\n\t\t\n\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t\n\n\t\t\n\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【muva】美姿骨盤枕\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t日本三合一美型舒筋板\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【強生】Cozy肩頸6D按摩\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【muva】健康趾力鞋\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t草本防蚊液*3＋防蚊包*10/箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t台灣在地養生特A級黑蒜\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【菇王】有機鹽麴\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【生態綠】可可組合\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t品諾14吋全方位DC直流馬達四季循環扇\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\ttokuyo型男美女提臀健腹機\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t檸檬白木耳淨透雙享組\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tMCT防彈咖啡隨身包入手組\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tcity traveler可加大18吋行李箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t勳風加熱式氣泡按摩足浴機\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tAmericanTraveler 20吋超輕量抗刮行李箱\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t鍋寶養生燉鍋1.8L +1元送友半年雜誌\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t《逆轉脂肪肝》\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t《有氧治百病：呼吸》\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t《排腸毒，不失智不罹癌》\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t《膝關節自癒術》\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t日本三合一美型舒筋板\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【Fun Sport】纖腰扭扭盤\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【muva】美姿骨盤枕\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\tFun Sport美肌塑體神拉器\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【origins foodist】近江糯麥\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【薌園】堅果糙米脆果\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【薌園】高纖豆漿\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t【生態綠OKO】綠咖啡\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\n\t\t\n\t清涼迎夏三部曲\n\t\n\t\t\n\t\t\n\t\t\t清涼迎夏三步曲\n簡單三步驟炎夏輕鬆擁有蓬鬆清爽的秀髮\t\t\n\t\n\t\n\t\t\t\n\n\t\t\t\n\n\t\t\t一年四季都適合端上桌的快手料理。備料迅速、不會花太多時間，滋味香醇潤口，忙碌的時候也能好好上菜，可說...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t國曆10月23-24日是秋天的最後一個節氣─霜降。在台灣可以明顯看見樹葉轉黃，也是賞菊的好時機；氣溫...\n\t\t\n\t\t\t\t\n\n\t\t\t\n\n\t\t\t人體為維持正常機能，除了五大營養素之外，還增加了膳食纖維與植化素；綠原酸即是植化素之一。綠原酸（Ch...\n\t\t\n\t\t\t\n\n\t\n\t\n\t\n\t\t\t\t大家最愛搜\n\t\t\n\t\t\t冷離心初榨暖暖包防蚊牛蒡茶【曼髮妮】天然染髮粉有機系列c5拉筋版，拉筋板，拉筋，拉筋板哪裡買，拉筋板推薦韃靼蕎麥燉鍋堅果泡腳機染髮綠藤亞麻籽油檸檬片高纖豆漿智利櫻桃【muva】3D蝶型纖體機瘦小腹口罩甜菊芝麻除體濕紅薑黃黑糖椰子油純可可粉哪裡買紅棗預防乳房籤維仁三樂事酪梨油維他命天然維他命高鈣黑芝麻美姿骨盤枕曼髮妮可可粉失智隨行杯豆漿助眠正髖關節苦茶油薑更年期消水腫tokuyo茶Sastty】染髮不過敏日本利尻昆布白髮染髮劑200g 黑色骨盆枕蝶豆花甜菜根洛神花紅茶清爽運動組防彈咖啡手工柴燒純黑巧克力亞麻仁油wp3922脊椎AS 快眠止鼾枕富含Omega-3十段活絡拉筋板瘦生酮飲食鬆筋按摩器黑巧克力鬆筋按摩可可純可可 100％純可可大輝可可無糖巧可力無糖可可拉筋板發現茶無花果天然染髮排腸毒艾草純可可粉咖啡順天堂肉桂黑豆蝶豆花茶枸杞薑黃益生菌堅果樂園熱敷墊紅薑黃冷壓亞麻籽鬆筋膜救疼痛鞋墊健腹器蝴蝶圈鴻參橄欖油南非國寶茶森林蜜脂肪肝排毒腳底按摩可可菇王鹽麴哪裡買，鹽麴，鹽渠，菇王染髮劑菊花茶、杭菊、茶包\t\t\n\t\n\t\n\n\n\t\n\t\t\n\n\t\t訂閱\n\t\t\t \n\t\t\t取消\n\t\t\n\t\n\t\n\t\t「早安健康嚴選」將定期透過電子報發送新品通知及最新優惠訊息，\n想要得到本站的第一手資訊嗎 ?\n快點留下信箱訂閱我們的電子報吧 !\n\t\n\n\n\n\n\n\t\n\n\n\n\n\t\n\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\n\t\t\n\t\t\n\t\t\t\n\t\t\t新品上市\n\t\t\t超值首選\n\t\t\t話題商品\n\t\t\t\n\t\t\t\n\t\t\t筋膜按摩\n\t\t\t瑜珈運動\n\t\t\t體重管理\n\t\t\t健身器材\n\t\t\t美體護具\n\t\t\t\n\t\t\t\n\t\t\t健康主食\n\t\t\t油醋調味\n\t\t\t健康飲品\n\t\t\t健康零食\n\t\t\t健康養生\n\t\t\t日本健康潮流\n\t\t\t\n\t\t\t\n\t\t\t無毒減塑好物\n\t\t\t個人保養\n\t\t\t生活居家\n\t\t\t生活家電\n\t\t\t\n\t\t\t\n\t\t\t免運訂閱方案\n\t\t\t零售雜誌套書\n\t\t\t電子雜誌\n\t\t\t\n\t\t\t\n\t\t\t人氣推薦食譜\n\t\t\t健康專題\n\t\t\t\n\t\t\t\n\t\t\t加入會員\n\t\t\t訂購流程說明\n\t\t\t付款配送說明\n\t\t\t退換貨說明\n\t\t\t\n\t\t\n\t\n\n\n\n\n\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t客服專線 02-5596-7262 ｜服務時間週一至週五 9:30-12:30/13:30-18:00\n\n\t\t\t©2018 早安健康股份有限公司版權所有，轉載必究 Copyright Everyday Health Co,Ltd All Rights Reserved"],["topImageUrl","https://ftp.pic.everydayhealth.com.tw/edh_upload/website_info/pic_logo_1.png?1475814226"],["error",null]]}]}],["text","(dozing)老是睡不飽？試試這個姿勢，10分鐘等於休息3小時！\nhttps://bit.ly/2fyQdir\n\n(ok)骨盆正了就會瘦！日本骨盤瘦身達人福辻鋭記推薦骨盤枕，輕鬆找回迷人腰線！雙12特價1212免運最後一天\nhttps://shop.everydayhealth.com.tw/l-1dnp8g"],["id","2ssg9fuzt61bx"],["createdAt","2018-12-14T06:05:40.999Z"]]}],["reply",{"__iterable":"Map","data":[["id","AWCYT4F-yCdS-nWhul8F"],["user",{"__iterable":"Map","data":[["id","AVriAlOoyrDaTqlmmqhC"],["name","Lin"],["avatarUrl",null],["level",22]]}],["type","RUMOR"],["text","運動養生方法僅供參考。必要時請諮詢專業醫師。"],["reference","https://health.udn.com/health/story/5999/1201482\n醫學研究缺驗證美學者：8成被誇大\nhttp://news.tvbs.com.tw/ttalk/blog_author_detail/4877\n8成是假的！別盲目相信網路上的養生資訊！"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title",""],["url","https://health.udn.com/health/story/5999/1201482"],["summary","「了解醫藥、保健、減肥瘦身、美容養生等健康議題；查詢各式疾病：高血壓、心臟病、憂鬱症、焦慮症、思覺失調、亞斯伯格症、神經衰弱、過敏、五十肩、糖尿病、感冒、過敏、失智症等等。」"],["topImageUrl","https://p.udn.com.tw/upf/2016_health/default.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","8成是假的！別盲目相信網路上的養生資訊！│十年流浪"],["url","http://news.tvbs.com.tw/ttalk/blog_author_detail/4877"],["summary","作者十年流浪\n \n \n 2016/10/12 08:10\n \n \n \n \n \n \n \n \n \n ▲圖片來源／Googoe提供 \n \n \n \n \n \n 我想每個人都應該有差不多的經驗，不管是你的LINE群組，你的FACEBOOK，多多少少都會有朋友分享打著科學研究報告或醫生證實等專業旗幟的各種的養生資訊。對於這種資訊，以前我是每則必讀並會在各種社交場合和其它人分享，這個多吃點，可以防癌，這個少吃點，對身體不好，順便刷刷我多聞強記的優越感。直到有一次，我看到了一則資訊和我以前讀過的不同。\n\n之前有研究報導指出隔夜菜會致癌，其論證原因是菜放隔夜會產生亞硝酸鹽，而亞硝酸鹽本身是致癌物。然而，我後來看到的報導又指出，根本沒有足夠的證據支持這個論證。第一，不只是蔬菜，你想的到的，能放進嘴巴的食物都含有亞硝酸鹽，括肉類、水果，甚至你喝的水。第二，這些食物所釋出的劑量非常小，人體機能本身能夠自行代謝，只有到達一定劑量才會使人體中毒。\n\n最後，也是最重要的，亞硝酸鹽本身不是致癌物，但亞硝酸鹽遇到胺類才會轉換為亞硝胺，後者才是致癌物。\n\n所以，吃隔夜菜最大的風險不是致癌，而是因保存不當使得細茵超出人體能負荷的範圍，也就是，就是會吃壞肚子。\n\n自此，我開始產生疑惑了，到底我該相信什麼？我以前所知道的資訊的可信度到底有多高？新的研究報告的可靠度又有多高呢？這疑惑一直存在並困擾著我，直到我看到了另一則報導，部份內容如下。\n\n史丹福大學的John Ioannidis 教授表示，目前發表的醫學研究中，有8成常見的非隨機研究，其結果都是錯誤的。他舉例，像是維他命E可降低心血管疾病死亡風險、類黃酮會降低80%的心血管死亡風險，低卡飲食會明顯降低癌症、心臟病、中風、乳癌風險，多吃水果可降低9成罹患乳癌機會等，「研究結果被誇大或過度概括（over generalizing）」 \n\n許多醫學研究缺乏驗證，John Ioannidis教授的研究團隊將同樣數據，以另一種統計方法分析，竟得出完全相反的結論。\n\n引述自：醫學研究欠驗證美學者：八成被誇大\n\nJohn Ioannidis教授在2005年發表的於一份論文『為何大部份發表的研究都是錯誤的』指出，他收集了1990~2003年國際上被引述一千次以上的權威醫學臨床論文共49篇並進行研究，其結果表明，只有二十篇論文被證實可靠，其餘的二十九篇，不是被證明無效，就是效果被誇大。最瞎的是，其中有幾篇論文的作者只有立論，連最基本的驗證都沒做。\n\n順道說明下，如今的意見領袖在FACEBOOK上發個直播或隨口說句中午吃什麼都可以按讚輕鬆破萬的情況下，這類論文被引用1000次是什麼概念？我上谷歌學術搜索上查了一下，截至2016年9月為止，這類學術被引用的次數大多都過不了一千次，John Ioannidis教授2005年的那篇這麼有話題性的論文被引用的次數是3千多次。因此，被引用1000次的論文代表著的是學界的共識。\n\n因此，如果連所謂權威專業論據的可靠度都不高，對於媒體報導和其它不知來源在自己社群上得到分享的養生資訊，我們又怎麼分辨其內容的可靠度呢？我自己的建議是以下二點，給大家參考下。\n\n第一種方法，因為我們不是專業，即使找到論文出及處論據的支持，我們也沒能力證偽，所以也就只能選擇相信。這就如同藥品在解盲測試階段為什麼要進行盲態測試？因為安慰劑在心理暗示下也會發揮一定效果。\n\n第二種，也是我目前採取的態度，保持中庸，不相信也不懷疑。不管我吃的致不致癌，不管對身體有沒有幫助，反正我什麼都吃，什麼都喝，但絕對謹記適可而止，絕對不會過猶不及。人生就是要體驗自己喜歡的事物，不必為了無法證實的資訊而去糾結，犧牲部份享受。\n\n>>來信投稿vanchang@tvbs.com.tw、閱讀好文都在【T談談】粉絲專頁！\n\n\n\n●本文為作者評論意見並授權刊登，不代表TVBS立場\n\n●投稿、推薦作者、討論文章，歡迎寄至vanchang@tvbs.com.tw或上 T談談\n\t\t\n \n \n 更新時間：2016/10/12 08:15\n \n 本文為作者評論意見並授權刊登，不代表TVBS立場。 \n \n \n \n \n \n \n \n dfp_lib->show_da(\"v4_news_desktop_ttalk_read_970x90_2\"); */?>\n \n\t\t\t\t\t\t\t\t\t\t \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n 名叫十年流浪，但己流浪了半輩。立志做個有人性的自由人。在這通用知識資訊泛濫且取得成本趨近於零的時代，希望能整合自產或他產的觀點分享給大家。"],["topImageUrl","https://cc.tvbs.com.tw/img/upload/2016/10/12/20161012081439-e1d46ebb.jpg"],["error",null]]}]}],["createdAt","2018-12-15T15:11:26.882Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",2],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_FxFJOU0PYt-POeEuxROBISc5mmlqOB1LN_rl2wHWgKY"],["name","理智的萬榮納特"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","全球最大纪录片节送福利，300余部影片免费在线观看"],["url","https://mp.weixin.qq.com/s/_uP9xUg0hV_JhkVgLuExVQ?fbclid=IwAR0FX3JExpQPd9Wzpuq5FTo4VAzUeyNkOLdj3oWgN_Gkav5sVugCa7g9Jmw"],["summary","今天要为大家推荐一份属于影迷的福利，全球最大的纪录片影展阿姆斯特丹纪录片节（idfa）在其官网放出300部以上全球纪录片供在线观看，如果你注册为会员还可以增加至500多部，可按国家，类型进行选择。链接直达：https://www.idfa.nl/en/info/watch-films-online-1?from=timeline&isappinstalled=0作为idfa的主办国，荷兰也遭受新冠疫情打击，目前荷兰已经有804例确诊患者，累计死亡10人。荷兰也严重缺乏医疗物资，目前已有大量医护人员感染，荷兰南部医护人员接受了检测，结果显示大约有4%的医护人员感染了新冠病毒。idfa放出数百部纪录片，也似乎是效仿欧洲部分美术馆，博物馆开放在线浏览的形式，意在鼓励民众留在家中，减少外出，而真正喜欢纪录片的影迷也可通过流媒体观看，规避电影院或影展观影的潜在疫情风险。2020年阿姆斯特丹纪录片节原定11月18日至29日进行，暂未宣布延期。位于荷兰阿姆斯特丹的IDFA创立于1988年，是迄今为止世界上最大的纪录片节。每年，IDFA都会展示全世界范围内挑选出的纪录片佳作。中国自1996开始便有作品入选IDFA，到2017年，总计有近百部纪录片被影展收录，包括周浩，杜海滨，徐童，顾桃，范俭等众多如今仍活跃在影坛的纪录片导演都曾有作品在IDFA入选，IDFA参与见证了新千年以来中国纪录片，尤其是中国独立纪录片的发展与成长。下文按年份整理出全部以“中国大陆”为制片国入选IDFA的纪录片，部分中国导演的作品以海外及港台报名影展（如王兵的《孤独》（2013）代表香港参展），本文未做收录。1996～2019，中国百部入围阿姆斯特丹纪录片节作品盘点2019年度2019年度入围作品为今日刚刚公布，多部华语纪录片入选各单元IDFA主竞赛单元：First Appearance竞赛单元韩萌《Smog Town》80分钟IDFA展映类单元：Frontlight 展映单元贾玉川《The Two Lives of Li Ermao》87分钟孙扬，江松长《时光机》81分钟张侨勇（加拿大华裔）《这不是一部电影》107分钟Luminous 展映单元《游神考》81分钟IDFA DocLab Spotlight单元Chien HuangVR实验纪录短片《失身记》31分钟官网完整入围片单：http://t.cn/Ai1PqG9j2018年度世外桃源The Land of Peach Blossoms周铭影Mingying Zhou | China | 2018 | 99minFirst Appearance竞赛单元火山Up the Mountain张杨Yang Zhang | China | 2018 | 126min长片竞赛单元红毛皇帝Dancing in the wind岳廷Ting Yue | China | 2018 | 89min学生竞赛单元死灵魂Dead Souls王兵Bing Wang | China／France／Switzerland | 2018 | 496min大师展映单元我的镜头Chinese Portrait王小帅Xiaoshuai Wang | China | 2018 | 90min大师展映单元安妮AnniRikun Zhu | China | 2018 | 78min佳片展映单元大字Big Characters雎安奇Anqi Ju | China | 2015 | 15min艺术展映单元Trapped in the City of a Thousand Mountains戴霍 DavidVerbeek短片竞赛单元IDFACompetitionforShortDocumentary2017年度二十四号大街 24th Street 潘志琪 Zhiqi Pan| China | 2017 | 88 min长片竞赛单元惊蛰 Awaken 宁佳伟｜中国｜2017｜63min中片竞赛单元行走敦煌 The Cave 赵琦｜中国｜2017｜13min纪录片实验竞赛单元芳舟 Lady of the Harbour 王申｜荷兰、中国｜2017｜95min荷兰竞赛单元团鱼岩 Turtle Rock 萧潇｜中国｜2017｜101min新人竞赛单元2016年度中国梵高 China's Van Goghs余海波 Haibo Yu, 余天琦 Kiki Tianqi Yu 2016 81 minA Chinese replica painter feels a deep affinity with Van Gogh and travelsto Amsterdam to find the spirit of his own work.俺爹俺娘 My Father and My Mother焦波 Bo Jiao 2016 88 minThe life of a simple Chinese couple, documented in thousands ofphotographs and many hours of video footage taken over a 30-yearperiod by their son, a well-known photographer.塑·料·王·国 Plastic China王久良 Jiu-liang Wang 2016 81 minYi Jie and her family live next to a primitive recycling plant. Her worldconsists of mountains of plastic waste from Europe, the United States andAsia.摇摇晃晃的人间 Still Tomorrow范俭 Jian Fan 2016 88 minDisabled by cerebral palsy and unhappily married, the painfully frankXiuhua Yu makes a dramatic breakthrough as a poet. Will fame solve herproblems?欢迎 Welcome朱日坤 Rikun Zhu 2016 63 minA raw and disturbing document that exposes the methods of the Chineseauthorities by allowing them to speak uncensored.2015年度大同 The Chinese Mayor周浩 Hao Zhou2015 87 minThe mayor of the Chinese city of Datong embarks on an immensedemolition and building project to transform his city into a touristattraction.我的诗篇 Chinese Verses吴飞跃 Feiyue Wu, 秦晓宇 Xiaoyu Qin2015 96 minChinese factory workers use poetry to break with their anonymity incandid expressions of their feelings and their hardships.对看 Look Love叶云 Yun Ye2015 146 minTwo Chinese children, one dirt poor, the other filthy rich. They both longfor affection, but neither have parents who can offer it. 我只认识你 Please Remember Me赵青 Qing Zhao2015 78 minAn elderly couple in Shanghai gracefully struggles with age, illness andmemory loss.大路朝天 The Road张赞波 Zanbo Zhang2015 95 minThe construction of a gigantic highway in China puts three parties at oddswith each other: local residents, the construction company and thelaborers.少年小赵 A Young Patriot杜海滨 Du Haibin2015 106 minAn intriguing portrait of a young Chinese nationalist who sees many of hisideals dashed over time.2014年度棉花 Cotton周浩 Zhou Hao2014 83 minMillions of Chinese farm laborers work in the cotton industry. The factoryprovides regular jobs, but is having to live so far from home really worthit?我就是我 I Am Here范立欣 Lixin Fan2014 88 minIDFA Award winner Lixin Fan follows the rite of passage of contestants inSuperboy, a Chinese talent competition for boys.铁西区 Tie Xi Qu: West of the Tracks王兵 Wang Bing2002 554 minA nine-hour meditative masterpiece about the decline of China’s biggestand oldest industrial area, and the consequences for the remainingworkers.2013年度四哥 The Fourth Brother徐童 Tong Xu2013 86 minAn intimate black-and-white portrait of an ex-con getting back to his oldtricks after spending half his life in jail.妈妈的村庄 Mothers许慧晶 Huijing Xu2013 70 minWoman's Care, the birth control center in a small Chinese village, startscracking down on women required to undergo sterilization.梦与影 Playing with Shadows牛小雨 Xiaoyu Niu2013 52 minIn a final attempt to turn his hobby into a job, passionate shadowpuppeteer Li Zi signs up for a TV talent pageant.查房 The Questioning朱日坤 Rikun Zhu2013 21 minThe human rights activist Rikun Zhu opens his door and is confronted bya horde of policemen – luckily he has a camera running, which they don’tnotice.Tiger MountainJie Wu2013 60 minThis moving film gives a voice to the residents of a village in the Chinesecountryside that has been polluted by the coal mining industry and nowreceives no attention whatsoever from the authorities.2012年度千锤百炼 China Heavyweight张侨勇 Yung Chang2012 93 minAn observational documentary on the rise of the Western sport of boxingin China. Will the young talents fight for their country, or themselves?出路 Education, Education陈为军 Weijun Chen2012 58 minDirector Chen Weijun uses three stories of young Chinese people to tell abigger story about the country's failing education system.殇城 Fallen City赵琦 Qi Zhao2012 88 minThree damaged families live in great sadness following an earthquake thathit the Chinese city of Beichuan, while a few miles from the rubble, a newcity is being built.革命是可以被原谅的 Fidaï丹米阳 Damien Ounouri2012 83 minA personal tale of an Algerian revolutionary, this is a story about fightingfor independence - both now and 50 years ago.归途列车 Last Train HomeLixin Fan2009 85 minKeeping the family together is the toughest job of all for the workers ofthe factories of a changing China, who only see their children on NewYear.2011年度死囚其言 Dead Men TalkingRobin Newell2011 52 minEvery year, about a thousand condemned prisoners are executed inChina. Just before their execution, journalist Ding Yu interviews some ofthem for her popular TV show.活着 The Next Life范俭 Fan Jian2011 54 minA Chinese couple whose only child died in the 2008 earthquake turn tomedicine to get pregnant again.最后的春光 The Vanishing Spring Light餘迅 Xun Yu2011 112 minThe lives of the inhabitants of West Street in Dujiangyan City, and inparticular Grandma Jiang, on the eve of radical urban renewal.2010年度2008·纪 Beijing 2008雷建军 Lei Jianjun2010 90 min2008 turns out to be a special year not only for the city of Beijing, wherethe Olympic Games are being held, but also for a resident of the citynamed Ji.殻 Crust黄文海 Wenhai Huang2010 13 minThe story behind the industrialization of China remains as mysterious asthe ghostly figures at the shipyard on the Yangtze River, working to aclaustrophobic soundtrack.海上传奇 I Wish I Knew贾樟柯 Jia Zhang Ke2010 138 minA poetic portrait of Shanghai that captures the present in images and thepast in the personal stories of its inhabitants.2009年度世界最大的中国餐馆The Biggest Chinese Restaurant in the World陈为军 Weijun Chen2008 80 minA film portrait of modern China as viewed through the prism of staff andguests at the largest Chinese restaurant in the world.采花大道 Gipsy in the Flower雎安奇 Anqi Ju2009 60 minA bittersweet portrait of a couple of Chinese beekeepers, who travel10,000 kilometers each year to places where the flowers bloom.贾医生的100个病人 A Hundred Patients of Dr. Jia王洪军 Wang Hongjun2009 105 minHectic scenes in Dr Jia's office. The comings and goings of patients and thepeople they bring along evolve into a charming group portrait.灯塔 Lighthouse殷子静 Chi-Jang Yin2009 16 minA portrait of the nocturnal existence of anonymous Chinese laborers whofight, smoke, play cards, and work, often without knowing that the camerais rolling.上言方 Petition赵亮 Zhao Liang2009 124 minThe inhabitants of Petition Village in Beijing and their daily struggle forjustice against the indifference of the Chinese totalitarian state.2008年度淹没2 Before the Flood II鄢雨 Yu Yan2008 60 minThe residents of a 1,700-year-old Chinese village are dumbfounded whenthey learn that the construction of a reservoir will put their homesunderwater.马夫 Horsemen吴慕清 Nancy Muqing Wu2008 98 minDaily life in the historic Chinese town of Songpan, where tourists makebreath-taking horse treks while the inhabitants are toiling away.老安 The Love of Mr An杨荔钠 Lina Yang2007 79 minAn elderly Chinese man falls in love with his dance partner, who is 30years his junior, but in the meantime has a furious wife waiting for him athome.2007年度红日风暴 Storm under the SunXiaolian Peng, S. Louisa Wei2007 170 minChairman Mao Zedong's deity status was achieved by destroying theautonomy of Chinese intellectuals through a series of political \"storms.\"木帮 Timber Gang于广义 Guangyi Yu2006 90 minLumberjacks in a mountainous area of China use a lumbering method thathas not changed for centuries. This film follows them during their lastwinter on the mountain.伞 Umbrella...杜海滨 Du Haibin2007 93 minIn five chapters, we see socially-defined Chinese groups of people duringtheir labour-intensive attempts to join in with the growing prosperity inChina.龙哥 Using周浩 Zhou Hao2007 145 minA hard-boiled portrait of a Chinese junkie; in Ah Long's mind, everyoneuses everyone else, albeit for different purposes.2006年度Amphibious (Login-Logout)Jennifer Allora, Guillermo Calzadilla2005 6 minA group of turtles rides atop a log as it drifts slowly along the fastamphibious network of import and export activities on the Pearl River inChina.The Big FamilyHuang Lingping2005 82 minA harrowing documentary soap about a rural family that is ruinedbecause of the patriarch's narrow-mindedness and incapacity.Change of ChoiceChen Ling2005 53 minAn account of the onerous, but sorely needed establishment of anagricultural co-op in a farming community dominated by different familyclans.村民影像计划 China Villagers Documentary Project张焕财、贾之坦等 Nong Ke, Zhang Huancai, Wang Wei, Zhou Cengjia, Shao Yuzhen, Ni Lianghui, Sqrolma Tshe Ring, Jia Zhitan, Fu Jiachong, Chujian Yi2006 95 minTen Chinese villagers make short films to document how the Chinesecountryside is struggling with democratic reforms.城市场景 City Scene赵亮 Zhao Liang2005 23 minA string of bizarre scenes from daily life in Beijing, a city in a state ofconfusion.达官营 Daguanying汤晓亮 Tang Xiaoliang, 刘珏欣 Liu Juexin2006 75 minThe elderly residents of an exclusive neighbourhood in Beijing are drivenout of their homes by the excavating machines of project developers.在城市里跳跃 Dancing in the City范俭 Fan Jian2006 118 minA portrait of four young Chinese people who leave their dead-end lives inthe countryside to build a new identity in Beijing.靖大爷和他的老主顾们 Grandpa Jing and His Old Customers施润玖 Shi Runjiu2003 55 minAn atmospheric homage to an 87-year-old barber named Jing. In an oldneighbourhood of Beijing, he reflects on life with the elderly customers hevisits.I Want a New HomeWang Dafei2005 24 minTingting is 10 years old. She resides on a small fishing boat, but wouldrather live in a real house.董家渡 Lotus Ferry周洪波 Zhou Hongbo2006 60 minA light-hearted and agile exploration of a busy old district of Shanghaisings of small, everyday worries and pleasures.在江边 Return to the Border赵亮 Zhao Liang2005 56 minChinese director returns to the Ya Lu River that separates China fromNorth Korea to see what is left of socialism in the two countries.高三 Senior Year周浩 Zhou Hao2005 95 minA detailed account of the pressures that high school seniors and theirteachers must cope with in the ruthless and conservative Chinese schoolsystem.石山 Stone Mountain杜海滨 Du Haibin2006 123 minThis visually stunning documentary on the struggle of miners in theBeijing province provides us with dramatic insight into the lives ofworkers in today's China.TransformationYang Gancai, Wang Yi2006 120 minAn enchanting portrait of a primitive agrarian community in the Chineserainforest. What happens when these lively, self-mocking people meetmodern civilisation?2005年度A Day to RememberLiu Wei2005 13 minWith one simple question, the filmmaker demonstrates that the studentuprising at Tiananmen Square is still a taboo subject in China.Growing UpChang Yu, Wang Dongdong2004 58 minAccount of the rigorous training of underprivileged Chinese children tobecome professional acrobats in a 2000-year-old tradition.Try to Remember钟键 Jian Zhong2005 90 minA son films his mother in the village where she grew up and hears storiesabout her childhood, which was dominated by poverty and the CulturalRevolution.2004年度嵌入肉体的城市 The Concrete Revolution郭小橹 Xiaolu Guo2004 60 minChinese writer and director comments in word and image on the price thenew China pays for joining the outside world.喧哗的尘土 Floating Dust黄文海 Wenhai Huang2004 111 minThe trials and tribulations of young unemployed adults in the Chinese cityof Yaoyang.碧色车站 Jade Green Station于坚 Yu Jian2003 122 minIn very little time, the sleepy village of Bise in China became a livelymeeting place after the construction of a railroad there.七月 July张虹 Tammy Cheung2004 80 minMassive protest march in Hong Kong against proposed new legislationthat would limit freedom.Separation and ReunionZhou Yu2004 41 minThe marriage registration office of the Dalian Xigang District in China. Asa hidden witness, the camera records the intimate stories of differentcouples in the midst of divorces and reunions.Travels by TricycleWang Dongdong2003 39 minA man takes his 98-year-old mother on a journey across China in atricycle trailer.2003年度被子 Quilts雎安奇 Ju An Qi2003 92 minThe filmmaker travels through China in search for intriguing quilts andthe stories of the people sleeping under them.好死不如赖活着 To Live Is Better than to Die陈为军 Weijun Chen2003 90 minSaddening portrait of a Chinese farmer’s family that tries to live with HIV– a result of the trade in blood in the nineties.2002年度Floating MemoryLiu Wei2001 10 minFormer revolutionary loses grip on memories of the Chinese uprising of1989.当兵 Interesting Times - Shao's Long March康健宁 Y. Gong2002 39 minShao Zhenning’s first three months in the Chinese People's LiberationArmy, transform him from a useless dropout into a spirited soldier.拎起大舌头 Interesting Times - The Secret of My Success段锦川 Jinchuan Duan2002 59 minIn Fanshen village, China - birth control policy leads to an unusual turn ofevents in the upcoming village council elections.爱情战争 Interesting Times - The War of Love段锦川 Jinchuan Duan, 蒋樾 Yue Jiang2002 39 minLove in China, depicted by scenes from the life of an amateurmatchmaker-cum-divorce lawyer-cum-unhappy wife.幸福生活 Interesting Times - This Happy Life蒋樾 Yue Jiang2002 94 minAn atmospheric and absurd film about Zhengzhou, China’s busiest trainstation, and two of it it’s employees - Mr. Fu and Mr. Liu.希望之旅 Railroad of Hope宁瀛 Ning Ying2001 52 minFor meagre wages, poor wretches travel across China for three days,meanwhile dreaming of a little money, a little happiness and a decent life.2001年度A Man With HIVTong Li1999 49 minAfter volunteering as a blood donor, the HIV virus is found in 31-year-oldLi Ziliang. He is immediately fired by his boss for fear of infection. Everytime he walks on the street, he is surrounded by groups of people thatstare at him. ‘One touch and you’re finished’, one of them thinks. ‘Peopl…居委会 Neighbourhood Committee张同道Tongdao Zhang2001 49 minIn China, neighbourhood committees play an important role in everydaylife. The committees arrange things for the local residents, they areintermediaries for government plans and they solve neighbourhoodquarrels. They also maintain order and monitor family planning. Since …纸飞机 Paper Airplane赵亮 Zhao Liang, Fan Jun Yi2001 90 minThey play in punk bands with names like Brain Failure Band and AnarchyJerks Band, and regularly stick needles in their arms. Once, rebellionspurred a group of Chinese youngsters who call themselves the HundredFlowers Club to start making music (‘Ignore taboos and rules!’), but no…RevengeMa Jia, Naotomo Umewaka2009 63 minTaking the form of a detective story, this documentary reveals the facts ofthe case of the kidnapping of a young mother, whose age is kept vague fora long time. On 1 April 2000, her brother reported the abduction ofMing’e, who was being forced to marry a farmer. The police liberated h…挣扎 Struggle舒浩仑 Shu Haolun2001 50 minThe city of Shenzhen, close to Hong Kong, was designated a SpecialEconomic Zone in the 1980s, a measure aimed at stimulating the localeconomy through reduced labour costs. This growth is taking its toll,however: every year, ten thousand migrant workers are injured perfor…城乡结合部 Where City and Country Meet张战庆 Zhang Zhanqing2001 90 minAround Beijing, some one million labourers from the Chinese countrysidelive in appalling conditions. Taking one family as an example, directorZhang Zhanqing shows the hopes and problems of living on the fringes ofprosperity. His film is not a social indictment; indeed, by following a frie…2000年度My GrasslandNing Cao1999 23 minOne year in the life of a family that lives on the Mongolian steppes.北京的风很大 There's a Strong Wind in Beijing雎安奇 Ju An Qi1999 48 minCamera crew asks passers-by in Beijing the nonsensical question, ‘Do youthink Beijing’s wind is strong?’1999年度疯狂英语 Crazy English张元 Zhang Yuan1999 90 minHilarious portrait of Li Yang, a Chinese teacher who teaches English tolarge groups of fellow-countrymen.江湖 Jiang Hu: Life on the Road吴文光 Wu Wenguang1999 149 minAccording to the ‘health inspection’, a travelling Chinese show smudgesthe streets of Beijing.婚事 Jiehun梁碧波 Bibo Liang1999 80 minIn China, the marriage ritual consists of six stages that must be completedaccording to the rules.The Elders季丹 Dan Ji, 苏青 Su Qing1999 60 minTibetan village elders pray, converse and resign themselves to theapproaching death.1998年度三节草 Home-coming in Granddaughter梁碧波 Bibo Liang1997 58 minElder woman returns to her native city Chengdu after 53 years.回到凤凰桥 Out of Phoenix Bridge李红 Hong Li1997 110 minFour girls who live and work together in Beijing talk about dreams, fearsand expectations with regard to their marital future.1996年度往事歌谣 Wang shi ge yao郑鸣 Zheng Ming1995 90 minFilm about the life and artistic career of old Wang Luobin, whose whole lifewas dedicated to collecting and performing folk songs from NorthwestChina. SONGS OF THE PAST takes the legendary musician to the place ofhis youth, where he brings back memories of the past and talks about hi…纪录片在荷兰一直是广受欢迎的艺术形式，一年一度的阿姆斯特丹国际纪录片电影节吸引了全球杰出纪录片电影人参展，将世界上每个角落的真实影像展现在银幕前，让观众无法再继续对长久被他们忽略的问题视而不见。无论是春运赶回家过年的中国民工，还是现代都会里饱受恐慌症之苦的阿姆斯特丹居民，纪录片导演们借由影像呈现现代生活的焦虑与无奈，讲述人们在逆境中找到光明与希望的真实故事。深秋的阿姆斯特丹阴雨绵绵，街头难得地显得冷清，顶着雨缩着颈项的行人面目严峻，然而一走到阿姆斯特丹著名的娱乐休闲区伦勃朗广场，一股来自异国的新鲜空气扑面而来。阿姆斯特丹国际纪录片电影节的宣传旗飘扬在各个街角，3000多名来自世界各地的电影爱好者、电影人和媒体记者用不同的语言表达他们对影片的观感，交换在不同国家和文化中拍片的心得。电影节创立于1988年的阿姆斯特丹国际纪录片电影节（IDFA，International Documentary Film Festival Amsterdam，19-29 Nov.）原本只是一个小型的电影活动，21年来逐渐演变成国际上最大型的纪录片盛会之一，今年更有近2500部纪录片参展。强调原创性与创意，阿姆斯特丹国际纪录片电影节在选片时特别注重影像工作者的个人观点与特殊的摄影与制作形式，虽然展出影片相当国际化，阿姆斯特丹纪录片电影节也开始重视本土的视野，在今年首度推出以荷兰纪录片为主的“低地”电影节大赛（Lowland），电影节主席Ally Derks表示：“我们希望这能够为维持荷兰丰富的纪录片传统做出一点贡献！”除此，阿姆斯特丹国际纪录片电影节也担负起推广纪录片艺术形式的重责，刚推出的“纪录片市场”（Docs for Sale）计划帮助纪录片导演寻找买主与展映机会，而有17年历史的the FORUM则是国际纪录片制片人与导演交流讨论、寻求财务支援的最佳场所；另外，成立于1998年的Jan Vrijman Fond更帮助了数百位发展中国家的电影人实现拍片梦想，中国导演范立欣就是获得Jan Vrijman基金奖助的幸运儿之一。纪录片节征片时间及费用以2019年为例2019.5.1（2018.8.1至2019.4.30完成的作品）2019.8.1（2019.4.30后完成的作品）费用：50欧元（不含增值税）征片要求1.非英语影片需有英文字幕。2.若作品的粗剪版本被拒绝，则不能在本届或下届电影节再次投递其更新版本。3.参选者应防止作品外泄。4.报名费用不予退还。5.长片作品在70分钟以上，中长片在40-70分钟内，短片不超过40分钟。学生纪录片单元无时长限制。6.需为世界/国际/欧洲首映作品，优先考虑世界首映。投递学生纪录片单元的作品可为荷兰首映。7.新人单元需提交导演的第一部作品。8.报名前至多在两个电影节或电影市场进行过放映。欧洲内进行市场放映需要得到电影节许可。9.允许在本国院线或电视进行放映，但曾经以互联网、流媒体、DVD等形式传播过的作品不可投递。投递方式在电影节官网https://www.idfa.nl/en/注册账号，填写申请表格，上传screener试看文件。投递单元及奖项设置纪录长片纪录中长片纪录短片新人纪录片学生纪录片最佳纪录长片纪录长片评审团特别奖最佳新人奖新人评审团特别奖最佳纪录中长片纪录中长片评审团特别奖最佳纪录短片纪录短片评审团特别奖最佳学生纪录片学生纪录片评审团特别奖观众选择奖Mediafonds基金纪录片奖IDFA最佳女性导演奖DocLab多媒体叙事奖DocLab浸入式纪实纪录片奖联系方式官网：https://www.idfa.nl/en/邮箱：info@idfa.nl电话：+31 20 6273329地址：International Documentary Film Festival AmsterdamFrederiksplein 52 1017 XN Amsterdam The Netherlands阿姆斯特丹国际纪录片影展也提供一个独立、激发灵感的交流平台，让观众与业界人士可以欣赏多元化及优质的影片。从纪录片形式、内容与导演的文化背景即可看出影展丰富多元的特质。除了主流娱乐、单一电影类型之外，IDFA 提供另一种影片选择以因应观众对于优质、发人省思的电影逐渐增加的需求。从2007 年开始，IDFA 的新媒体单元和纪录片实验室展示极佳的互动式、非剧情类的故事叙述，并探讨数位革命如何重塑纪录片的美学。除了影展之外，IDFA 已发展多样专业活动，协助处于各个发展阶段中的导演及其影片成长萌芽。在跨国跨资制片市场展上，参展导演与制作人向赞助商竭力推销自己的拍片计画；而在纪录片买卖市场展，许多刚出炉的纪录片供节目买家和片商挑选。伯莎基金为资助开发中国家的导演和纪录片拍片计画，IDFA 学院则专门训练全球新锐纪录片导演。📎过去10年，全球最佳纪录片110部交易担保实验影像中心实验影像中心·策展单元 Mini Program 「导筒」微信号 directube2016 📎庆祝“举报问题”被广泛讨论，导筒手机壳买一赠一📎异业合作 | 导筒2020年文末广告位招募推广/合作/活动加微信号：directubeee"],["topImageUrl",null],["error",null]]}]}],["text","新冠疫情期間的最大享受😄\n\n一份屬於影迷的福利，全球最大的纪录片影展阿姆斯特丹纪录片节（idfa）在其官网放出300部以上全球纪录片供在线观看！\n如果你注册为会员还可以增加至500多部，可按国家，类型进行选择。\n\nhttps://mp.weixin.qq.com/s/_uP9xUg0hV_JhkVgLuExVQ?fbclid=IwAR0FX3JExpQPd9Wzpuq5FTo4VAzUeyNkOLdj3oWgN_Gkav5sVugCa7g9Jmw"],["id","25ypo7x9o4nkv"],["createdAt","2020-03-20T15:32:08.879Z"]]}],["reply",{"__iterable":"Map","data":[["id","7Bgt5HEBrhVJn3LNH0a-"],["user",{"__iterable":"Map","data":[["id","nhgg5HEBrhVJn3LNTkUn"],["name","老吳"],["avatarUrl","https://www.gravatar.com/avatar/0837c7712906dde6f5d4dcdf8bbc51cf?s=100&d=identicon&r=g"],["level",1]]}],["type","NOT_RUMOR"],["text","此為荷蘭阿姆斯特丹國際紀錄片影展(International Documentary Film Festival Amsterdam)的官方網站，一點進去即可看到官網將Watch Films Online放在最上面。"],["reference","https://www.idfa.nl/en/"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title",""],["url","https://www.idfa.nl/en/"],["summary",""],["topImageUrl",null],["error","NOT_REACHABLE"]]}]}],["createdAt","2020-05-05T09:31:34.723Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",2],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_FxFJOU0PYt-POeEuxROBISc5mmlqOB1LN_rl2wHWgKY"],["name","理智的萬榮納特"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","全球最大纪录片节送福利，300余部影片免费在线观看"],["url","https://mp.weixin.qq.com/s/_uP9xUg0hV_JhkVgLuExVQ?fbclid=IwAR0FX3JExpQPd9Wzpuq5FTo4VAzUeyNkOLdj3oWgN_Gkav5sVugCa7g9Jmw"],["summary","今天要为大家推荐一份属于影迷的福利，全球最大的纪录片影展阿姆斯特丹纪录片节（idfa）在其官网放出300部以上全球纪录片供在线观看，如果你注册为会员还可以增加至500多部，可按国家，类型进行选择。链接直达：https://www.idfa.nl/en/info/watch-films-online-1?from=timeline&isappinstalled=0作为idfa的主办国，荷兰也遭受新冠疫情打击，目前荷兰已经有804例确诊患者，累计死亡10人。荷兰也严重缺乏医疗物资，目前已有大量医护人员感染，荷兰南部医护人员接受了检测，结果显示大约有4%的医护人员感染了新冠病毒。idfa放出数百部纪录片，也似乎是效仿欧洲部分美术馆，博物馆开放在线浏览的形式，意在鼓励民众留在家中，减少外出，而真正喜欢纪录片的影迷也可通过流媒体观看，规避电影院或影展观影的潜在疫情风险。2020年阿姆斯特丹纪录片节原定11月18日至29日进行，暂未宣布延期。位于荷兰阿姆斯特丹的IDFA创立于1988年，是迄今为止世界上最大的纪录片节。每年，IDFA都会展示全世界范围内挑选出的纪录片佳作。中国自1996开始便有作品入选IDFA，到2017年，总计有近百部纪录片被影展收录，包括周浩，杜海滨，徐童，顾桃，范俭等众多如今仍活跃在影坛的纪录片导演都曾有作品在IDFA入选，IDFA参与见证了新千年以来中国纪录片，尤其是中国独立纪录片的发展与成长。下文按年份整理出全部以“中国大陆”为制片国入选IDFA的纪录片，部分中国导演的作品以海外及港台报名影展（如王兵的《孤独》（2013）代表香港参展），本文未做收录。1996～2019，中国百部入围阿姆斯特丹纪录片节作品盘点2019年度2019年度入围作品为今日刚刚公布，多部华语纪录片入选各单元IDFA主竞赛单元：First Appearance竞赛单元韩萌《Smog Town》80分钟IDFA展映类单元：Frontlight 展映单元贾玉川《The Two Lives of Li Ermao》87分钟孙扬，江松长《时光机》81分钟张侨勇（加拿大华裔）《这不是一部电影》107分钟Luminous 展映单元《游神考》81分钟IDFA DocLab Spotlight单元Chien HuangVR实验纪录短片《失身记》31分钟官网完整入围片单：http://t.cn/Ai1PqG9j2018年度世外桃源The Land of Peach Blossoms周铭影Mingying Zhou | China | 2018 | 99minFirst Appearance竞赛单元火山Up the Mountain张杨Yang Zhang | China | 2018 | 126min长片竞赛单元红毛皇帝Dancing in the wind岳廷Ting Yue | China | 2018 | 89min学生竞赛单元死灵魂Dead Souls王兵Bing Wang | China／France／Switzerland | 2018 | 496min大师展映单元我的镜头Chinese Portrait王小帅Xiaoshuai Wang | China | 2018 | 90min大师展映单元安妮AnniRikun Zhu | China | 2018 | 78min佳片展映单元大字Big Characters雎安奇Anqi Ju | China | 2015 | 15min艺术展映单元Trapped in the City of a Thousand Mountains戴霍 DavidVerbeek短片竞赛单元IDFACompetitionforShortDocumentary2017年度二十四号大街 24th Street 潘志琪 Zhiqi Pan| China | 2017 | 88 min长片竞赛单元惊蛰 Awaken 宁佳伟｜中国｜2017｜63min中片竞赛单元行走敦煌 The Cave 赵琦｜中国｜2017｜13min纪录片实验竞赛单元芳舟 Lady of the Harbour 王申｜荷兰、中国｜2017｜95min荷兰竞赛单元团鱼岩 Turtle Rock 萧潇｜中国｜2017｜101min新人竞赛单元2016年度中国梵高 China's Van Goghs余海波 Haibo Yu, 余天琦 Kiki Tianqi Yu 2016 81 minA Chinese replica painter feels a deep affinity with Van Gogh and travelsto Amsterdam to find the spirit of his own work.俺爹俺娘 My Father and My Mother焦波 Bo Jiao 2016 88 minThe life of a simple Chinese couple, documented in thousands ofphotographs and many hours of video footage taken over a 30-yearperiod by their son, a well-known photographer.塑·料·王·国 Plastic China王久良 Jiu-liang Wang 2016 81 minYi Jie and her family live next to a primitive recycling plant. Her worldconsists of mountains of plastic waste from Europe, the United States andAsia.摇摇晃晃的人间 Still Tomorrow范俭 Jian Fan 2016 88 minDisabled by cerebral palsy and unhappily married, the painfully frankXiuhua Yu makes a dramatic breakthrough as a poet. Will fame solve herproblems?欢迎 Welcome朱日坤 Rikun Zhu 2016 63 minA raw and disturbing document that exposes the methods of the Chineseauthorities by allowing them to speak uncensored.2015年度大同 The Chinese Mayor周浩 Hao Zhou2015 87 minThe mayor of the Chinese city of Datong embarks on an immensedemolition and building project to transform his city into a touristattraction.我的诗篇 Chinese Verses吴飞跃 Feiyue Wu, 秦晓宇 Xiaoyu Qin2015 96 minChinese factory workers use poetry to break with their anonymity incandid expressions of their feelings and their hardships.对看 Look Love叶云 Yun Ye2015 146 minTwo Chinese children, one dirt poor, the other filthy rich. They both longfor affection, but neither have parents who can offer it. 我只认识你 Please Remember Me赵青 Qing Zhao2015 78 minAn elderly couple in Shanghai gracefully struggles with age, illness andmemory loss.大路朝天 The Road张赞波 Zanbo Zhang2015 95 minThe construction of a gigantic highway in China puts three parties at oddswith each other: local residents, the construction company and thelaborers.少年小赵 A Young Patriot杜海滨 Du Haibin2015 106 minAn intriguing portrait of a young Chinese nationalist who sees many of hisideals dashed over time.2014年度棉花 Cotton周浩 Zhou Hao2014 83 minMillions of Chinese farm laborers work in the cotton industry. The factoryprovides regular jobs, but is having to live so far from home really worthit?我就是我 I Am Here范立欣 Lixin Fan2014 88 minIDFA Award winner Lixin Fan follows the rite of passage of contestants inSuperboy, a Chinese talent competition for boys.铁西区 Tie Xi Qu: West of the Tracks王兵 Wang Bing2002 554 minA nine-hour meditative masterpiece about the decline of China’s biggestand oldest industrial area, and the consequences for the remainingworkers.2013年度四哥 The Fourth Brother徐童 Tong Xu2013 86 minAn intimate black-and-white portrait of an ex-con getting back to his oldtricks after spending half his life in jail.妈妈的村庄 Mothers许慧晶 Huijing Xu2013 70 minWoman's Care, the birth control center in a small Chinese village, startscracking down on women required to undergo sterilization.梦与影 Playing with Shadows牛小雨 Xiaoyu Niu2013 52 minIn a final attempt to turn his hobby into a job, passionate shadowpuppeteer Li Zi signs up for a TV talent pageant.查房 The Questioning朱日坤 Rikun Zhu2013 21 minThe human rights activist Rikun Zhu opens his door and is confronted bya horde of policemen – luckily he has a camera running, which they don’tnotice.Tiger MountainJie Wu2013 60 minThis moving film gives a voice to the residents of a village in the Chinesecountryside that has been polluted by the coal mining industry and nowreceives no attention whatsoever from the authorities.2012年度千锤百炼 China Heavyweight张侨勇 Yung Chang2012 93 minAn observational documentary on the rise of the Western sport of boxingin China. Will the young talents fight for their country, or themselves?出路 Education, Education陈为军 Weijun Chen2012 58 minDirector Chen Weijun uses three stories of young Chinese people to tell abigger story about the country's failing education system.殇城 Fallen City赵琦 Qi Zhao2012 88 minThree damaged families live in great sadness following an earthquake thathit the Chinese city of Beichuan, while a few miles from the rubble, a newcity is being built.革命是可以被原谅的 Fidaï丹米阳 Damien Ounouri2012 83 minA personal tale of an Algerian revolutionary, this is a story about fightingfor independence - both now and 50 years ago.归途列车 Last Train HomeLixin Fan2009 85 minKeeping the family together is the toughest job of all for the workers ofthe factories of a changing China, who only see their children on NewYear.2011年度死囚其言 Dead Men TalkingRobin Newell2011 52 minEvery year, about a thousand condemned prisoners are executed inChina. Just before their execution, journalist Ding Yu interviews some ofthem for her popular TV show.活着 The Next Life范俭 Fan Jian2011 54 minA Chinese couple whose only child died in the 2008 earthquake turn tomedicine to get pregnant again.最后的春光 The Vanishing Spring Light餘迅 Xun Yu2011 112 minThe lives of the inhabitants of West Street in Dujiangyan City, and inparticular Grandma Jiang, on the eve of radical urban renewal.2010年度2008·纪 Beijing 2008雷建军 Lei Jianjun2010 90 min2008 turns out to be a special year not only for the city of Beijing, wherethe Olympic Games are being held, but also for a resident of the citynamed Ji.殻 Crust黄文海 Wenhai Huang2010 13 minThe story behind the industrialization of China remains as mysterious asthe ghostly figures at the shipyard on the Yangtze River, working to aclaustrophobic soundtrack.海上传奇 I Wish I Knew贾樟柯 Jia Zhang Ke2010 138 minA poetic portrait of Shanghai that captures the present in images and thepast in the personal stories of its inhabitants.2009年度世界最大的中国餐馆The Biggest Chinese Restaurant in the World陈为军 Weijun Chen2008 80 minA film portrait of modern China as viewed through the prism of staff andguests at the largest Chinese restaurant in the world.采花大道 Gipsy in the Flower雎安奇 Anqi Ju2009 60 minA bittersweet portrait of a couple of Chinese beekeepers, who travel10,000 kilometers each year to places where the flowers bloom.贾医生的100个病人 A Hundred Patients of Dr. Jia王洪军 Wang Hongjun2009 105 minHectic scenes in Dr Jia's office. The comings and goings of patients and thepeople they bring along evolve into a charming group portrait.灯塔 Lighthouse殷子静 Chi-Jang Yin2009 16 minA portrait of the nocturnal existence of anonymous Chinese laborers whofight, smoke, play cards, and work, often without knowing that the camerais rolling.上言方 Petition赵亮 Zhao Liang2009 124 minThe inhabitants of Petition Village in Beijing and their daily struggle forjustice against the indifference of the Chinese totalitarian state.2008年度淹没2 Before the Flood II鄢雨 Yu Yan2008 60 minThe residents of a 1,700-year-old Chinese village are dumbfounded whenthey learn that the construction of a reservoir will put their homesunderwater.马夫 Horsemen吴慕清 Nancy Muqing Wu2008 98 minDaily life in the historic Chinese town of Songpan, where tourists makebreath-taking horse treks while the inhabitants are toiling away.老安 The Love of Mr An杨荔钠 Lina Yang2007 79 minAn elderly Chinese man falls in love with his dance partner, who is 30years his junior, but in the meantime has a furious wife waiting for him athome.2007年度红日风暴 Storm under the SunXiaolian Peng, S. Louisa Wei2007 170 minChairman Mao Zedong's deity status was achieved by destroying theautonomy of Chinese intellectuals through a series of political \"storms.\"木帮 Timber Gang于广义 Guangyi Yu2006 90 minLumberjacks in a mountainous area of China use a lumbering method thathas not changed for centuries. This film follows them during their lastwinter on the mountain.伞 Umbrella...杜海滨 Du Haibin2007 93 minIn five chapters, we see socially-defined Chinese groups of people duringtheir labour-intensive attempts to join in with the growing prosperity inChina.龙哥 Using周浩 Zhou Hao2007 145 minA hard-boiled portrait of a Chinese junkie; in Ah Long's mind, everyoneuses everyone else, albeit for different purposes.2006年度Amphibious (Login-Logout)Jennifer Allora, Guillermo Calzadilla2005 6 minA group of turtles rides atop a log as it drifts slowly along the fastamphibious network of import and export activities on the Pearl River inChina.The Big FamilyHuang Lingping2005 82 minA harrowing documentary soap about a rural family that is ruinedbecause of the patriarch's narrow-mindedness and incapacity.Change of ChoiceChen Ling2005 53 minAn account of the onerous, but sorely needed establishment of anagricultural co-op in a farming community dominated by different familyclans.村民影像计划 China Villagers Documentary Project张焕财、贾之坦等 Nong Ke, Zhang Huancai, Wang Wei, Zhou Cengjia, Shao Yuzhen, Ni Lianghui, Sqrolma Tshe Ring, Jia Zhitan, Fu Jiachong, Chujian Yi2006 95 minTen Chinese villagers make short films to document how the Chinesecountryside is struggling with democratic reforms.城市场景 City Scene赵亮 Zhao Liang2005 23 minA string of bizarre scenes from daily life in Beijing, a city in a state ofconfusion.达官营 Daguanying汤晓亮 Tang Xiaoliang, 刘珏欣 Liu Juexin2006 75 minThe elderly residents of an exclusive neighbourhood in Beijing are drivenout of their homes by the excavating machines of project developers.在城市里跳跃 Dancing in the City范俭 Fan Jian2006 118 minA portrait of four young Chinese people who leave their dead-end lives inthe countryside to build a new identity in Beijing.靖大爷和他的老主顾们 Grandpa Jing and His Old Customers施润玖 Shi Runjiu2003 55 minAn atmospheric homage to an 87-year-old barber named Jing. In an oldneighbourhood of Beijing, he reflects on life with the elderly customers hevisits.I Want a New HomeWang Dafei2005 24 minTingting is 10 years old. She resides on a small fishing boat, but wouldrather live in a real house.董家渡 Lotus Ferry周洪波 Zhou Hongbo2006 60 minA light-hearted and agile exploration of a busy old district of Shanghaisings of small, everyday worries and pleasures.在江边 Return to the Border赵亮 Zhao Liang2005 56 minChinese director returns to the Ya Lu River that separates China fromNorth Korea to see what is left of socialism in the two countries.高三 Senior Year周浩 Zhou Hao2005 95 minA detailed account of the pressures that high school seniors and theirteachers must cope with in the ruthless and conservative Chinese schoolsystem.石山 Stone Mountain杜海滨 Du Haibin2006 123 minThis visually stunning documentary on the struggle of miners in theBeijing province provides us with dramatic insight into the lives ofworkers in today's China.TransformationYang Gancai, Wang Yi2006 120 minAn enchanting portrait of a primitive agrarian community in the Chineserainforest. What happens when these lively, self-mocking people meetmodern civilisation?2005年度A Day to RememberLiu Wei2005 13 minWith one simple question, the filmmaker demonstrates that the studentuprising at Tiananmen Square is still a taboo subject in China.Growing UpChang Yu, Wang Dongdong2004 58 minAccount of the rigorous training of underprivileged Chinese children tobecome professional acrobats in a 2000-year-old tradition.Try to Remember钟键 Jian Zhong2005 90 minA son films his mother in the village where she grew up and hears storiesabout her childhood, which was dominated by poverty and the CulturalRevolution.2004年度嵌入肉体的城市 The Concrete Revolution郭小橹 Xiaolu Guo2004 60 minChinese writer and director comments in word and image on the price thenew China pays for joining the outside world.喧哗的尘土 Floating Dust黄文海 Wenhai Huang2004 111 minThe trials and tribulations of young unemployed adults in the Chinese cityof Yaoyang.碧色车站 Jade Green Station于坚 Yu Jian2003 122 minIn very little time, the sleepy village of Bise in China became a livelymeeting place after the construction of a railroad there.七月 July张虹 Tammy Cheung2004 80 minMassive protest march in Hong Kong against proposed new legislationthat would limit freedom.Separation and ReunionZhou Yu2004 41 minThe marriage registration office of the Dalian Xigang District in China. Asa hidden witness, the camera records the intimate stories of differentcouples in the midst of divorces and reunions.Travels by TricycleWang Dongdong2003 39 minA man takes his 98-year-old mother on a journey across China in atricycle trailer.2003年度被子 Quilts雎安奇 Ju An Qi2003 92 minThe filmmaker travels through China in search for intriguing quilts andthe stories of the people sleeping under them.好死不如赖活着 To Live Is Better than to Die陈为军 Weijun Chen2003 90 minSaddening portrait of a Chinese farmer’s family that tries to live with HIV– a result of the trade in blood in the nineties.2002年度Floating MemoryLiu Wei2001 10 minFormer revolutionary loses grip on memories of the Chinese uprising of1989.当兵 Interesting Times - Shao's Long March康健宁 Y. Gong2002 39 minShao Zhenning’s first three months in the Chinese People's LiberationArmy, transform him from a useless dropout into a spirited soldier.拎起大舌头 Interesting Times - The Secret of My Success段锦川 Jinchuan Duan2002 59 minIn Fanshen village, China - birth control policy leads to an unusual turn ofevents in the upcoming village council elections.爱情战争 Interesting Times - The War of Love段锦川 Jinchuan Duan, 蒋樾 Yue Jiang2002 39 minLove in China, depicted by scenes from the life of an amateurmatchmaker-cum-divorce lawyer-cum-unhappy wife.幸福生活 Interesting Times - This Happy Life蒋樾 Yue Jiang2002 94 minAn atmospheric and absurd film about Zhengzhou, China’s busiest trainstation, and two of it it’s employees - Mr. Fu and Mr. Liu.希望之旅 Railroad of Hope宁瀛 Ning Ying2001 52 minFor meagre wages, poor wretches travel across China for three days,meanwhile dreaming of a little money, a little happiness and a decent life.2001年度A Man With HIVTong Li1999 49 minAfter volunteering as a blood donor, the HIV virus is found in 31-year-oldLi Ziliang. He is immediately fired by his boss for fear of infection. Everytime he walks on the street, he is surrounded by groups of people thatstare at him. ‘One touch and you’re finished’, one of them thinks. ‘Peopl…居委会 Neighbourhood Committee张同道Tongdao Zhang2001 49 minIn China, neighbourhood committees play an important role in everydaylife. The committees arrange things for the local residents, they areintermediaries for government plans and they solve neighbourhoodquarrels. They also maintain order and monitor family planning. Since …纸飞机 Paper Airplane赵亮 Zhao Liang, Fan Jun Yi2001 90 minThey play in punk bands with names like Brain Failure Band and AnarchyJerks Band, and regularly stick needles in their arms. Once, rebellionspurred a group of Chinese youngsters who call themselves the HundredFlowers Club to start making music (‘Ignore taboos and rules!’), but no…RevengeMa Jia, Naotomo Umewaka2009 63 minTaking the form of a detective story, this documentary reveals the facts ofthe case of the kidnapping of a young mother, whose age is kept vague fora long time. On 1 April 2000, her brother reported the abduction ofMing’e, who was being forced to marry a farmer. The police liberated h…挣扎 Struggle舒浩仑 Shu Haolun2001 50 minThe city of Shenzhen, close to Hong Kong, was designated a SpecialEconomic Zone in the 1980s, a measure aimed at stimulating the localeconomy through reduced labour costs. This growth is taking its toll,however: every year, ten thousand migrant workers are injured perfor…城乡结合部 Where City and Country Meet张战庆 Zhang Zhanqing2001 90 minAround Beijing, some one million labourers from the Chinese countrysidelive in appalling conditions. Taking one family as an example, directorZhang Zhanqing shows the hopes and problems of living on the fringes ofprosperity. His film is not a social indictment; indeed, by following a frie…2000年度My GrasslandNing Cao1999 23 minOne year in the life of a family that lives on the Mongolian steppes.北京的风很大 There's a Strong Wind in Beijing雎安奇 Ju An Qi1999 48 minCamera crew asks passers-by in Beijing the nonsensical question, ‘Do youthink Beijing’s wind is strong?’1999年度疯狂英语 Crazy English张元 Zhang Yuan1999 90 minHilarious portrait of Li Yang, a Chinese teacher who teaches English tolarge groups of fellow-countrymen.江湖 Jiang Hu: Life on the Road吴文光 Wu Wenguang1999 149 minAccording to the ‘health inspection’, a travelling Chinese show smudgesthe streets of Beijing.婚事 Jiehun梁碧波 Bibo Liang1999 80 minIn China, the marriage ritual consists of six stages that must be completedaccording to the rules.The Elders季丹 Dan Ji, 苏青 Su Qing1999 60 minTibetan village elders pray, converse and resign themselves to theapproaching death.1998年度三节草 Home-coming in Granddaughter梁碧波 Bibo Liang1997 58 minElder woman returns to her native city Chengdu after 53 years.回到凤凰桥 Out of Phoenix Bridge李红 Hong Li1997 110 minFour girls who live and work together in Beijing talk about dreams, fearsand expectations with regard to their marital future.1996年度往事歌谣 Wang shi ge yao郑鸣 Zheng Ming1995 90 minFilm about the life and artistic career of old Wang Luobin, whose whole lifewas dedicated to collecting and performing folk songs from NorthwestChina. SONGS OF THE PAST takes the legendary musician to the place ofhis youth, where he brings back memories of the past and talks about hi…纪录片在荷兰一直是广受欢迎的艺术形式，一年一度的阿姆斯特丹国际纪录片电影节吸引了全球杰出纪录片电影人参展，将世界上每个角落的真实影像展现在银幕前，让观众无法再继续对长久被他们忽略的问题视而不见。无论是春运赶回家过年的中国民工，还是现代都会里饱受恐慌症之苦的阿姆斯特丹居民，纪录片导演们借由影像呈现现代生活的焦虑与无奈，讲述人们在逆境中找到光明与希望的真实故事。深秋的阿姆斯特丹阴雨绵绵，街头难得地显得冷清，顶着雨缩着颈项的行人面目严峻，然而一走到阿姆斯特丹著名的娱乐休闲区伦勃朗广场，一股来自异国的新鲜空气扑面而来。阿姆斯特丹国际纪录片电影节的宣传旗飘扬在各个街角，3000多名来自世界各地的电影爱好者、电影人和媒体记者用不同的语言表达他们对影片的观感，交换在不同国家和文化中拍片的心得。电影节创立于1988年的阿姆斯特丹国际纪录片电影节（IDFA，International Documentary Film Festival Amsterdam，19-29 Nov.）原本只是一个小型的电影活动，21年来逐渐演变成国际上最大型的纪录片盛会之一，今年更有近2500部纪录片参展。强调原创性与创意，阿姆斯特丹国际纪录片电影节在选片时特别注重影像工作者的个人观点与特殊的摄影与制作形式，虽然展出影片相当国际化，阿姆斯特丹纪录片电影节也开始重视本土的视野，在今年首度推出以荷兰纪录片为主的“低地”电影节大赛（Lowland），电影节主席Ally Derks表示：“我们希望这能够为维持荷兰丰富的纪录片传统做出一点贡献！”除此，阿姆斯特丹国际纪录片电影节也担负起推广纪录片艺术形式的重责，刚推出的“纪录片市场”（Docs for Sale）计划帮助纪录片导演寻找买主与展映机会，而有17年历史的the FORUM则是国际纪录片制片人与导演交流讨论、寻求财务支援的最佳场所；另外，成立于1998年的Jan Vrijman Fond更帮助了数百位发展中国家的电影人实现拍片梦想，中国导演范立欣就是获得Jan Vrijman基金奖助的幸运儿之一。纪录片节征片时间及费用以2019年为例2019.5.1（2018.8.1至2019.4.30完成的作品）2019.8.1（2019.4.30后完成的作品）费用：50欧元（不含增值税）征片要求1.非英语影片需有英文字幕。2.若作品的粗剪版本被拒绝，则不能在本届或下届电影节再次投递其更新版本。3.参选者应防止作品外泄。4.报名费用不予退还。5.长片作品在70分钟以上，中长片在40-70分钟内，短片不超过40分钟。学生纪录片单元无时长限制。6.需为世界/国际/欧洲首映作品，优先考虑世界首映。投递学生纪录片单元的作品可为荷兰首映。7.新人单元需提交导演的第一部作品。8.报名前至多在两个电影节或电影市场进行过放映。欧洲内进行市场放映需要得到电影节许可。9.允许在本国院线或电视进行放映，但曾经以互联网、流媒体、DVD等形式传播过的作品不可投递。投递方式在电影节官网https://www.idfa.nl/en/注册账号，填写申请表格，上传screener试看文件。投递单元及奖项设置纪录长片纪录中长片纪录短片新人纪录片学生纪录片最佳纪录长片纪录长片评审团特别奖最佳新人奖新人评审团特别奖最佳纪录中长片纪录中长片评审团特别奖最佳纪录短片纪录短片评审团特别奖最佳学生纪录片学生纪录片评审团特别奖观众选择奖Mediafonds基金纪录片奖IDFA最佳女性导演奖DocLab多媒体叙事奖DocLab浸入式纪实纪录片奖联系方式官网：https://www.idfa.nl/en/邮箱：info@idfa.nl电话：+31 20 6273329地址：International Documentary Film Festival AmsterdamFrederiksplein 52 1017 XN Amsterdam The Netherlands阿姆斯特丹国际纪录片影展也提供一个独立、激发灵感的交流平台，让观众与业界人士可以欣赏多元化及优质的影片。从纪录片形式、内容与导演的文化背景即可看出影展丰富多元的特质。除了主流娱乐、单一电影类型之外，IDFA 提供另一种影片选择以因应观众对于优质、发人省思的电影逐渐增加的需求。从2007 年开始，IDFA 的新媒体单元和纪录片实验室展示极佳的互动式、非剧情类的故事叙述，并探讨数位革命如何重塑纪录片的美学。除了影展之外，IDFA 已发展多样专业活动，协助处于各个发展阶段中的导演及其影片成长萌芽。在跨国跨资制片市场展上，参展导演与制作人向赞助商竭力推销自己的拍片计画；而在纪录片买卖市场展，许多刚出炉的纪录片供节目买家和片商挑选。伯莎基金为资助开发中国家的导演和纪录片拍片计画，IDFA 学院则专门训练全球新锐纪录片导演。📎过去10年，全球最佳纪录片110部交易担保实验影像中心实验影像中心·策展单元 Mini Program 「导筒」微信号 directube2016 📎庆祝“举报问题”被广泛讨论，导筒手机壳买一赠一📎异业合作 | 导筒2020年文末广告位招募推广/合作/活动加微信号：directubeee"],["topImageUrl",null],["error",null]]}]}],["text","新冠疫情期間的最大享受😄\n\n一份屬於影迷的福利，全球最大的纪录片影展阿姆斯特丹纪录片节（idfa）在其官网放出300部以上全球纪录片供在线观看！\n如果你注册为会员还可以增加至500多部，可按国家，类型进行选择。\n\nhttps://mp.weixin.qq.com/s/_uP9xUg0hV_JhkVgLuExVQ?fbclid=IwAR0FX3JExpQPd9Wzpuq5FTo4VAzUeyNkOLdj3oWgN_Gkav5sVugCa7g9Jmw"],["id","25ypo7x9o4nkv"],["createdAt","2020-03-20T15:32:08.879Z"]]}],["reply",{"__iterable":"Map","data":[["id","cgXv-HABrhVJn3LN13w3"],["user",{"__iterable":"Map","data":[["id","_1YnAG8BV0DITCqGm7go"],["name","uienwt"],["avatarUrl",null],["level",18]]}],["type","NOT_RUMOR"],["text","全球最大的紀錄片影展:荷蘭阿姆斯特丹國際紀錄片影展(IDFA)官網釋出300部以上精選全球紀錄片供線上免費收看。"],["reference","https://www.facebook.com/permalink.php?id=245844405552615&story_fbid=1734213520049022\n荷蘭阿姆斯特丹國際紀錄片影展(IDFA)"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","Security check"],["url","https://www.facebook.com/permalink.php?id=245844405552615&story_fbid=1734213520049022"],["summary","Please enter the code belowWhy am I seeing this?"],["topImageUrl",null],["error",null]]}]}],["createdAt","2020-03-20T17:13:52.701Z"]]}]]},{"__iterable":"Map","data":[["article",{"__iterable":"Map","data":[["replyCount",1],["references",{"__iterable":"List","data":[{"__iterable":"Map","data":[["type","LINE"]]}]}],["replyRequestCount",1],["user",{"__iterable":"Map","data":[["id","j4S8C_8SU6w_lKU8142Pd-hyVJRULJNF7mjehuE3om7Vc6i8c"],["name","滿足的✖東勢✖艾薇拉"],["avatarUrl",null],["level",0]]}],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","Diabetes drug is promising Alzheimer's treatment after 'significantly reversing' memory loss"],["url","http://www.independent.co.uk/news/health/alzheimers-diabetes-drug-memory-loss-reverse-disease-treatment-degenerative-a8133681.html"],["summary","A drug developed for type 2 diabetes significantly reverses memory loss and could have potential as a new treatment for Alzheimer’s disease and other neurodegenerative diseases, scientists say.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n The study, by UK and Chinese universities, is the first to look at a new combined diabetes drug and found improvements in several characteristic symptoms of Alzheimer’s.\n \n\n \n \n \n \n \n\n\n\n \n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n Lead researcher Professor Christian Holscher, from Lancaster University, said these “very promising outcomes” show multi-action drugs developed for type 2 diabetes “consistently show neurological protective effects”.\n \n\n \n \n \n \n \n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n Independent academics said a reduction in nerve-cell-killing protein molecules was particularly interesting and this was likely to be another avenue in the search for an elusive drug to combat dementia.\n \n\n \n \n \n \n \n\n\n\n\n\n \n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n He has previously reported optimistic findings from an older diabetes drug, liraglutide, and clinical trials in humans are currently under way.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n This latest study, published in the journal Brain Research, looked at a “triple action” treatment that combine three different drugs for type 2 diabetes, acting on biological pathways that could also have an impact on dementia.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n \n \n\n\n\n\n\n \n \n \n \n \n \n \n\n \n \n \n Type 2 diabetes is a known risk factor for Alzhemier’s disease and impaired production of insulin – the hormone that people with diabetes don’t produce sufficiently to control their blood sugar – is linked to brain degeneration.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n The identification of this link had a twofold benefit, according to charities.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n It opened up new research and drug development opportunities, such as this study.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n But it also means that by making lifestyle changes, like eating healthily and exercising, patients can avoid developing type-2 diabetes and lower their risk of Alzheimer’s disease as well.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n There are currently half a million people living with Alzheimer’s disease in the UK and more than five million people with diabetes, both conditions pose a major cost to the NHS, and health systems worldwide.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n \n\n \n\n \n \n \n The treatment in this study combined; GLP-1, GIP and glucagon, which, like insulin protect against neurological deterioration, and tested them in mice with genetic mutations that cause Alzheimer’s disease.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n After two months of daily injections the mice were shown to significantly improve their performance in a maze designed to test memory.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n \n \n\n \n\n\n\n\n\n \n \n \n \n \n Treated mice also had lower levels of proteins which clump together and form plaques in the brains of people with Alzheimer’s disease, inhibiting nerve cells’ ability to communicate and causing them to die.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n The study also found these mice lost nerve cells to the disease at a slower rate and had lower levels of nerve inflammation.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n It concludes that the triple treatment “holds clear promise of being developed into a new treatment for chronic neurodegenerative disorders such as Alzheimer’s disease”.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n \n \n\n \n\n\n\n\n\n \n \n \n \n \n \n \nThe seven Alzheimer's risk factors\n\n\n\n\n \n\n\n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n\n\n \n\n \n \n \n The Alzheimer’s Society, a charity which part-funded the latest study research, said that after 15 years without a new drug for Alzheimer’s disease the promising results from these crossover treatments, which are already known to be safe for humans, are likely to bring earliest benefits.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n Professor Holscher added that further tests to compare its benefits against other potential treatments, and its effects in humans were needed.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n\n\n\n\n\n \n \n \n \n \n But Professor John Hardy, a professor of neuroscience, at University College London who was not involved in the trial, said the study was “a first step, at best” towards a Alzheimer’s drug for humans.\n \n\n \n \n \n \n \n\n\n\n\n\n\n\n\n \n \n \n \n \n\n \n\n\n\n\n\n \n \n \n \n \n “The results showing less amyloid deposition of amyloid in mice treated with glucagon receptor stimulating drugs is interesting,” he said.\n \n\n \n \n \n \n \n \n “However, it should be noted that several other drugs have shown positive results in mice models of Alzheimer’s disease and then failed in human trials.”\n \n\n \n \n \n \n \n \n Dr David Reynolds, chief scientific officer at Alzheimer’s Research UK, echoed this, but added: “There is a long road between studies that show an effect in animals and treatments in the hands of patients, and scientists will only be able to realise the potential of promising findings like these if we continue to invest in research.”"],["topImageUrl","https://static.independent.co.uk/s3fs-public/thumbnails/image/2015/04/14/21/web-alzheimers-2-alamy.jpg"],["error",null]]},{"__iterable":"Map","data":[["title","Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease"],["url","https://www.sciencedirect.com/science/article/pii/S0006899317304596"],["summary","AbstractType 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD). Previous studies have shown that the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) that have anti-diabetic properties show very promising effects in animal models of AD. Glucagon (Gcg) is a hormone and growth-factor, and the Gcg receptor is expressed in the brain. Here we test the effects of a triple receptor agonist (TA), which activates GIP-1, GIP and glucagon receptors at the same time. In the present study, the effects of the TA were evaluated in the APP/PS1 transgenic mouse model of AD. The TA was injected once-daily (10 nmol/kg i.p.) for two months. The results showed that treatment with TA significantly reversed the memory deficit in the APP/PS1 mice in a spatial water maze test. Moreover, the drug reduced levels of the mitochondrial pro-apoptotic signaling molecule BAX, increased the anti-apoptotic signaling molecule Bcl-2 and enhanced the levels of BDNF, a key growth factor that protects synaptic function. Levels of synaptophysin were enhanced, demonstrating protection from synaptic loss that is observed in AD. Neurogenesis in the dentate gyrus was furthermore enhanced as shown in the increase of doublecortin positive cells. Furthermore, TA treatment reduced the total amount of β-amyloid, reduced neuroinflammation (activated microglia and astrocytes), and oxidative stress in the cortex and hippocampus. Thus, these findings show that novel TAs are a promising lead for the design of future treatment strategies in AD.Previous Next KeywordsInflammationGrowth factorBDNFBrainInsulinNeurodegeneration1. IntroductionAlzheimer’s disease (AD), is a progressive neurodegenerative disease, characterized clinically by progressive memory loss, cognitive decline, and aberrant behavior [1]. Currently, there is no treatment can improve this condition. Epidemiological studies have shown that type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD) (Luchsinger et al., 2004, Ohara et al., 2011). The underlying mechanism is most likely that insulin signaling is impaired in the brains of AD patients (Moloney et al., 2010, Talbot et al., 2012). This motivated research in drugs that have shown good effects in treating diabetes to investigate if they could be helpful in treating AD as well. Previous studies have shown that the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) can play a neuroprotective role in the brain and show very promising effects in animal models of AD (Duffy and Holscher, 2013, Faivre and Holscher, 2013b, Li et al., 2010, McClean et al., 2011, McClean and Holscher, 2014). Glucagon (Gcg) is a hormone and growth-factor, and the Gcg receptor is expressed in the brain (Hoosein and Gurd, 1984, Mayo et al., 2003). Activation of the receptor can activate neuronal activity and cellular Ca2+ signaling and may have neuroprotective properties (Ayush et al., 2015). Here we test the effects of a triple receptor agonist (TA), which activates GIP-1, GIP and glucagon receptors at the same time. This novel drug has been developed as a potential treatment for diabetes (Finan et al., 2015). No studies have been published that test the neuroprotective effects of this novel drug. We therefore tested this promising TA in the APPSWE/PS1dE9 mouse model of AD. This mouse model recapitulates some of the hallmarks of AD, such as memory loss, synaptic loss, reduction of synaptic plasticity, reduction of neurogenesis in the dentate gyrus, chronic inflammation in the brain, and formation of amyloid plaques in the brain (Duffy and Holscher, 2013, Goto et al., 2008, Hamilton et al., 2011, Hamilton and Holscher, 2012, McClean et al., 2011). We tested the effects of TA in this transgenic mouse model and evaluated the neuroprotective effects. We analyzed memory formation, hippocampal neurogenesis, the expression levels of Brain Derived Neurotrophic Factor (BDNF) (Blurton-Jones et al., 2009), mitochondrial apoptosis signaling proteins, neuroinflammation and oxidative stress levels.2. Results2.1. TA-treatment improved the learning and memory impairment of APP/PS1 mice in the water mazeA two-way ANOVA found a significant difference between groups (p < 0.0001) and over time (p < 0.001). In the Morris water test, it was observed that the control mice, APP/PS1 mice and TA-treated APP/PS1 mice had a similar escape latency (P > 0.05). On day 5, the average escape distance in searching for the hidden platform in the APP/PS1 mice was significantly longer than that in the control mice (P < 0.05). Compared to the APP/PS1 group, the TA-treated APP/PS1 group’s average escape distance was decreased (P < 0.01). There was no difference in swimming speed among these three groups in training days (P > 0.05).Then on day 6, the platform was removed and the probe trail test was conducted. A one way ANOVA analysis showed an overall difference between groups. The APP/PS1 mice spent less time in the target quadrant (P < 0.01) and had fewer times passing through the original position of the hidden platform (P < 0.01), compared with control mice. In the TA-treated APP/PS1 group, the time spent in target quadrant (P < 0.05) and the frequencies to cross the platform significantly increased (P < 0.05), compared to the APP/PS1 group Fig. 1.Download high-res image (302KB)Download full-size imageFig. 1. The novel TA improved the learning ability of APP/PS1 mice in the spatial water maze task. (A) The escape latency and swimming speed in the training trails. (B) The percentage of time in target quadrant and crossing platform times in the probe trials. The circle indicates the position of the platform during acquisition (C) Representative swimming tracks of the probe trial. * = P < .05, ** = P < .01 compared to the control group, ## = P < .01, # = P < .05 compared to the APP/PS1 group; Two-way ANOVA with Bonferroni repeated measures post hoc tests.2.2. TA-treatment ameliorated amyloid plaques in the brains of APP/PS1 miceIn the immunohistochemical analysis, we analyzed the amount of amyloid plaques present in the brains of APP-PS1 mice. A one-way ANOVA found an overall difference on the amyloid deposits in the cortex (F = 31.10, P < 0.0001) and the hippocampus (F = 30.38, P < 0.0001) of mice between groups. The Aβ1-42 depositions in the cortex and hippocampus of the APP/PS1 mice were significantly higher than that in the control mice (P < 0.001), while TA-treatment group significantly decreased the deposition (P < 0.001) compared to the APP/PS1 group. N = 6 per group. See Fig. 2.Download high-res image (211KB)Download full-size imageFig. 2. TA treatment reduced amyloid deposits in the cortex and hippocampus of APP/PS1 mice. A, D: control group; B, E: APP/PS1 group; C, F: APP/PS1+TA group. Scale bar in image D: 100 μm. *** = P < .001 compared to the control group; ### = P < .001 compared to the APP/PS1 group. One-way ANOVA with Bonferroni repeated measures post hoc tests. N = 6 per group.2.3. TA-treatment reduced the chronic inflammation response in the cortex and hippocampus of the APP/PS1 miceIn the immunohistochemical analysis, an anti-GFAP antibody was used as an indication of activated astrocytes. A one-way ANOVA found an overall difference on the GFAP expression in the cortex (F = 77.03, P < 0.0001) and the hippocampus (F = 86.51, P < 0.0001) of mice between groups. The levels of GFAP in the cortex and hippocampus of the APP/PS1 mice were significantly higher than that in the control mice (P < 0.001), while TA-treatment group significantly decreased (P < 0.001) compared to the APP/PS1 group. N = 6 per group. See Fig. 3.Download high-res image (362KB)Download full-size imageFig. 3. TA-treatment reduced the number of GFAP positive cells in the cortex and hippocampus of APP/PS1 mice. A, D: control group; B, E: APP/PS1 group; C, F: APP/PS1+TA. Scale bar in image D: 50μm. A higher magnification image has been added to show stained astroglia. *** = P < .001 compared with the control group; ### = P < .001 compared with the APP/PS1 group. One-way ANOVA with Bonferroni repeated measures post hoc tests. N = 6 per group.In the immunohistochemical analysis, an anti-IBA1 antibody was used as an indication of microglia activation. A one-way ANOVA found an overall difference on the IBA-1 expression in the cortex (F = 28.71, P < 0.0001) and the hippocampus (F = 66.42, P < 0.0001) of mice between groups. The levels of IBA-1 in the cortex and hippocampus of the APP/PS1 mice were significantly higher than that in the control mice (P < 0.001), while TA-treatment group significantly decreased (P < 0.001, P < 0.01) compared to the APP/PS1 group. N = 6 per group. See Fig. 4.Download high-res image (347KB)Download full-size imageFig. 4. TA treatment reversed the increase of IBA-1 positive cells in the cortex and hippocampus of APP/PS1 mice. A, D: control group; B, E: APP/PS1 group; C, F: APP/PS1+TA group. Scale bar in image D: 100 μm. A higher magnification image has been added to show stained microglia. *** = P < .001 compared to the control group; ## = P < .01, ### = P < .001 compared to the APP/PS1 group. One-way ANOVA with Bonferroni repeated measures post hoc tests. N = 6 per group.2.4. TA-treatment suppressed oxidative stress in the cortex and hippocampus of APP /PS1 miceIn the immunohistochemical analysis, 4-HNE was measured as an indicator of lipid peroxidation. A one-way ANOVA found an overall difference on the 4-HNE expression in the cortex (F = 60.60, P < 0.0001) and the hippocampus (F = 35.22, P < 0.0001) of mice between groups. The expressions of 4-HNE in the cortex and hippocampus of the APP/PS1 mice were significantly higher than that in the control mice (P < 0.001), while TA-treatment group significantly decreased (P < 0.001) compared to the APP/PS1 group. N = 6 per group, see Fig. 5a.Download high-res image (397KB)Download full-size imageFig. 5. Oxidative stress was reduced by the TA. 5A. TA-treatment reduced the increase of 4-HNE levels in the cortex and hippocampus in APP/PS1 mice. A, D: control group; B, E: APP/PS1 group; C, F: APP/PS1+TA group. Scale bar in image D: 100 μm. *** = P < .001 compared with controls; ###=P < .001 compared to the APP/PS1 group. 5B. TA treatment reduced the increase of 8-OHdG levels in the cortex and hippocampus of APP/PS1 mice. A, D: control group; B, E: APP/PS1 group; C, F: APP/PS1+TA group. Scale bar in image D: 100 μm. *** = P < .001 compared to the control group; ## = P < .01, ### = P < .001 compared with the APP/PS1 group. One-way ANOVA with Bonferroni repeated measures ***post hoc tests. N = 6 per group.In the immunohistochemical analysis, 8-OHdG was measured as an indicator of DNA oxidation. A one-way ANOVN found an overall difference on the 8-OHdG expression in the cortex (F = 38.72, P < 0.0001) and the hippocampus (F = 56.60, P < 0.0001) of mice between groups. The expressions of 8-OHdG in the cortex and hippocampus of the APP/PS1 mice were significantly higher than that in the control mice (P < 0.001), while TA-treatment group significantly decreased (P < 0.01, P < 0.001) compared to the APP/PS1 group. N = 6 per group, see Fig. 5b.2.5. TA-treatment increased immature neurons in the dentate gyrus of APP/PS1 miceIn the immunohistochemical analysis, numbers of neurogenesis, assessed by doublecortin (DCX). A one-way ANOVN found an overall difference on the DCX positive cell in the dentate gyrus (F = 43.61, P < 0.0001) of mice between groups. The numbers of DCX were much reduced in the APP/PS1 mice (P < 0.001) compared to the control mice. While TA-treatment partially prevented the reduction (P < 0.001) compared to the APP/PS1 mice. N = 6 per group. See Fig. 6.Download high-res image (169KB)Download full-size imageFig. 6. TA-treatment enhanced neurogenesis and increased numbers of DCX positive cell numbers in the dentate gyrus of APP/PS1 mice. A: control group; B: APP/PS1 group; C: APP/PS1+TA group. Scale bar in image A: 100 μm. *** = P < .001 compared with the control group; ### = P < .001 compared with the APP/PS1 group. One-way ANOVA with Bonferroni repeated measures post hoc tests. N = 6 per group.2.6. TA-treatment reversed the decrease of BDNF levels in the hippocampus of APP/PS1 miceBDNF, a key neurotrophic factor in the brain, was detected by Western blot analysis. A one-way ANOVA found an overall difference between groups (F = 20.01, P < 0.001). The expression of BDNF in hippocampus was reduced in APP/PS1 group (P < 0.001) compared to the control group. TA-treatment reversed the decreased (P < 0.05) compared to the APP/PS1 group. N = 6 per group. See Fig. 7a.Download high-res image (304KB)Download full-size imageFig. 7. A) TA-treatment increased levels of BDNF in the hippocampus of APP/PS1 mice. *** = P < .001compared with the control group; # = P < .05 compared with the APP/PS1 group. N = 6 per group. B) TA-treatment increased levels of synaptophysin in the hippocampus of APP/PS1 mice. *** = P < .001 compared with the control group; ## = P < .01 compared with the APP/PS1 group. N = 6 per group. C) TA-treatment increased the ratio of BAX/Bcl-2 in the hippocampus of APP/PS1 mice. *** = P < .001 compared with the control group; ### = P < .001 compared with the APP/PS1 group. One-way ANOVA with Bonferroni repeated measures post hoc tests. N = 6 per group.2.7. TA-treatment reversed the reduction of synaptophysin levelsSynaptophysin (SYN), a synaptic markers, was detected by Western blot analysis. A one-way ANOVA found an overall difference between groups (F = 20.46, P < 0.001). The level of SYN in hippocampus was decreased in the APP/PS1 group (P < 0.001) compared to the control group. While TA-treatment prevent the reduction (P < 0.01) compared to the APP/PS1 group. N = 6 per group. See Fig. 7b.2.8. TA-treatment showed potential anti-apoptotic effects by decreasing the BAX/Bcl-2 ratio in APP/PS1 miceThe expression of apoptotic proteins, including Bcl-2 (that suppress apoptosis) and BAX (that promotes apoptosis), was detected by Western blot analysis. A one-way ANOVA found an overall difference between groups (F = 77.64, P < 0.001). The ratio of BAX/Bcl-2 in hippocampus was increased (P < 0.001) compared to the control group. While TA-treatment partly decreased the ratio of BAX/Bcl-2 (P < 0.001) compared to the APP/PS1 group. N = 6 per group. See Fig. 7c.3. DiscussionThe results demonstrate for the first time that the novel GLP-1/GIP/Gcg receptor agonist has clear neuroprotective effects in the APP/PS1 mouse model of AD. Memory formation in the spatial water maze task was improved by the drug, and the amyloid plaque load in the cortex and hippocampus was reduced. This result confirms our previous findings that single GLP-1 or GIP analogues can protect from memory loss in this mouse model of AD (Faivre and Holscher, 2013a, Faivre and Holscher, 2013b, McClean et al., 2011, McClean and Holscher, 2014). The chronic inflammation response as seen in the activation of microglia and astrocytes is much reduced by the novel TA, similar to single GLP-1 or GIP receptor agonists (Duffy and Holscher, 2013, Ji et al., 2016a, McClean et al., 2011). Levels of the peroxidized lipid 4-HNE that also acts as a pro-apoptotic signal in mitochondria have been reduced by the TA. 4-HNE is one of the markers of membrane lipid peroxidation induced by cytotoxic radicals such as OH. 4-HNE has cytotoxic, mutagenic and genotoxic properties and 4-HNE is reported to stimulate apoptosis via caspase 3 activation and by inducing mitochondrial damage as shown in cytochrome c release (Ji et al., 2001). The levels of the mitochondrial apoptosis signal BAX (Kim et al., 2005) were also reduced. Importantly, the anti-apoptotic signaling molecule B-cell lymphoma 2 (Bcl-2) which is active in functioning mitochondria that have normal inner membrane voltage potentials (Kavitha et al., 2013) is upregulated by the TA, adding to the neuroprotective effect. The level of chronic oxidative stress as measure by the levels of the oxidized nucleotide 8-Hydroxiguanosine (8-OHdG) was also reduced by the drug. Neurogenesis in the dentate gyrus was normalized. Importantly, the levels of the key growth factor BDNF were normalized in the brain. BDNF has shown clear neuroprotective effects in a range of animal models of disease (Allen et al., 2013, Benedetti et al., 2014, Blurton-Jones et al., 2009, Nagahara et al., 2013). An important factor of BNDF activity is that it maintains synaptic activity and protects synapses from stressors (Kuipers and Bramham, 2006). The observation that the synaptic marker synaptophysin was expressed at normal levels after TA treatment also indicates that synaptic numbers and function was improved in the AD mouse. We have shown previously that GLP-1 and GIP analogues protect synapses from amyloid induced stress and keeps them functional (Faivre and Holscher, 2013b, Gault and Holscher, 2008a, Gault and Holscher, 2008b, McClean and Holscher, 2014).Recently, multiple receptor agonists have been developed to treat type II diabetes (Finan et al., 2013, Finan et al., 2015). We have tested novel dual GLP-1/GIP receptor agonists that showed good neuroprotective effects that are superior to single GLP-1 analogues (Cao et al., 2016, Jalewa et al., 2017, Ji et al., 2016b, Yuan et al., 2017). The novel dual agonist DA3-CH was found to be superior to liraglutide in a mouse model of Parkinson’s disease (Yuan et al., 2017), demonstrating that the strategy of activating more than one incretin receptor type offers an advantage over single receptor agonists. Here, we show that a novel triple receptor agonist also shows promise as a potential treatment for AD, but further dose–response tests and direct comparisons with other drugs have to be conducted in order to evaluate if this new drug is superior to previous ones.GLP-1, GIP and glucagon are members of the growth factor family (Hölscher, 2016). Their respective receptors are classic 7-membrane spanning domain, G-protein coupled receptors that activate cAMP synthesis (Campbell and Drucker, 2013, Doyle and Egan, 2007, Holst et al., 2011). The activation of the second messenger cascade cAMP-PKA-CREB induces a number of cytoprotective processes, including the normalization of energy utilization, cell repair and growth-factor related gene expression (Holscher, 2014, Jalewa et al., 2016, Perry and Greig, 2004, Sharma et al., 2013). Importantly, GLP-1 and GIP also have anti-inflammatory properties. Astroglia and microglia express the receptors, and activating these reduce the inflammation response (Duffy and Holscher, 2013, Jalewa et al., 2017, Parthsarathy and Holscher, 2013, Spielman et al., 2017). Chronic inflammation is a main driver of neurodegenerative disorders, and a reduction of the inflammation in the brain shows protective effects (Akiyama et al., 2000, Clark et al., 2012, Lee et al., 2010).Based on the impressive preclinical data that demonstrate neuroprotection of such drugs, clinical trials have started that investigate the neuroprotective effects of the GLP-1 receptor agonists exendin-4 (Byetta, Bydureon®) and liraglutide (Victoza®) in patients with AD or with Parkinson disease (PD). A pilot study testing the GLP-1 analogue liraglutide in AD patients showed promising results. In a double blind, placebo controlled trial, AD patients showed no deterioration in brain activity as measured in the 18FDG-PET scan after 12 months of drug treatment. In contrast, the placebo group showed clear reductions in cortical activity as expected for this progressive neurodegenerative disease (Gejl et al., 2016). A phase II clinical trial is currently ongoing (Hölscher, 2016). A pilot trial testing exendin-4 in PD patients has shown good effects (NCT01174810). This open-label study tested the effects of exendin-4 in 45 patients. There were clear improvements in the motor coordination as shown in the MDS-UPDRS part 3 assessment, and cognition was improved as measured by the Mattis DRS-2 test battery that had been designed to evaluate cognitive impairments in PD patients (Aviles-Olmos et al., 2013). Patients were re-tested 12 months later, and the differences in motor performance and cognitive scores were still visible (Aviles-Olmos et al., 2014). A phase II double-blind, placebo controlled clinical trial that tested the once-weekly formulation of exendin-4, Bydureon®, confirmed the results of the pilot study. The drug group did not deteriorate in the MDS-UPDRS part 3 assessment after 48 weeks of treatment, and after 12 weeks of a wash-out period, the disease-modifying effect was still visible. In contrast, the placebo group deteriorated over time as would be expected in this disease (Athauda et al., 2017). In addition, a phase II trial testing liraglutide in PD patients has started, testing patients in a double blind, placebo controlled trial for one year (NCT02953665). A further clinical trial testing the GLP-1 receptor agonist Lixisenatide in PD patients is in planning.These very promising preclinical and the first clinical outcomes demonstrate the efficacy of these novel multiple receptor agonists that originally were developed to treat type II diabetes, but have shown consistent neuroprotective effects in several studies. In the present study, the novel TA improved learning and memory, reduce amyloid plaque load, chronic inflammation and oxidative stress, as well as mitochondrial stress signaling, and improved BDNF release and synaptic markers while normalising neurogenesis in the dentate gyrus. The novel triple GLP-1/GIP/Gcg receptor agonist holds clear promise of being developed into a new treatment for chronic neurodegenerative disorders such as Alzheimer’s disease.4. Materials and methods4.1. Peptide and chemicalsThe triple GLP-1/GIP/Gcg used in this study was synthesized by China Peptides Co, Ltd. (Shanghai, China) to 95% purity. The identity and purity of the peptide was confirmed by reversed-phase HPLC and characterized using matrix assisted laser resorption/ionization time of flight (MALDI–TOF) mass spectrometry. The peptide was stored in dry form and dissolved in double-distilled water containing 0.9% NaCl2 before experiments. A Bi-cinchoninicacid (BCA) protein assay kit was purchased from Apply gen Technologies Inc. (Beijing, China). 3, 3-diaminobenzidine (DAB) was purchased from ZSGB-BIO Co. (Beijing, China). The primary antibodies recognizing Aβ1-42, IBA-1, BDNF, 4-Hydroxynonenal (4-HNE), 8-Hydroxyguanosine (8-OHdG), synaptophysin (SYN) and β-actin were obtained from Abcam (Cambridge, UK). The primary antibody GFAP, Bcl-2, and BAX were obtained from Boster Biotechnology (Wuhan, China). The primary antibody doublecortin (DCX) buy from Santa Cruz Biotechnology. HRP-labeled goat anti-rabbit immunoglobulin was obtained from Abcam (Cambridge, UK). The biotinylated goat anti-rabbit IgG, biotinylated rabbit anti-goat IgG, avidinbiotin peroxidase complex reagent was purchased from Boster Biotechnology (Wuhan, China). All other reagents used in the research were of analytical grade and of the highest quality commercially available. The peptide sequence was as follows (Finan et al., 2015):HXQGTFTSDKSKYLDERAAQDFVQWLLDGGPSSGAPPPSX = aminoisobutyric acid, K = γE-C16 acylation (with a C16 fatty acid).4.2. Animals and treatmentsAPP/PS1 transgenic mice were purchased from the Academy of Military Medical Sciences (AMMS, China), were maintained in a constant temperature (22 ± 1 °C) and humidity (relative 30%) under a 12 h light/dark cycle in animal house. As well as age-matched non-AD mice, which are wild-type animals as control. When animals were 6 months of age, TA was dissolved in saline. The dose was a once-daily injection of 10 nmol/kg body weight ip. for two months. Injections were given in the morning (8:00 am). Control mice received equal volumes of saline solution. All experimental procedures involving animals were approved by the Institutional Animal Care Committee of Shanxi Medical University and conform to the guidelines of National Institute of Health (NIH) guideline (NIH publication No. 85-23. Revised 1985). They were divided into three different groups (n = 12). (i): control group treated with saline only; (ii): APP/PS1 group treated with saline only; (iii): APP/PS1 group treated with TA. At the end of drug treatments, measurements of behavioral change, neuronal damage, oxidative stress and inflammatory markers were conducted.4.3. Morris water maze testThe water maze test is a standard method for assessing learning and memory in animals. The water maze (WM) task was performed 5 days after two months intraperitoneal injection. The apparatus was a circular, white painted pool (150 cm in diameter and 60 cm in height) which was filled to a depth of 40 cm with warm water at a temperature 23 ± 2 °C to avoid hypothermia, and was surrounded by a white curtain around the pool. The pool was divided into four quadrants with four starting locations, north (N), east (E), south (S) and west (W), the starting quadrant was randomly chosen. A perspex platform (diameter, 10 cm) was located in a specific location during the acquisition trials and submerged approximately 1.0 cm below the surface of the water. A video camera was mounted directly above the pool to record the movement and the trail of the mice. During the acquisition phase, each mouse was subjected to four consecutive training trials on each day. The mouse was gently placed in the water between the quadrants, and allowed 60 s to search the hidden platform. If it failed to find the platform within 60 s, it was guided to the platform and allowed to remain there for 10 s. Training continued for 5 days. On the sixth day, the hidden platform was removed and each mouse was allowed to swim in the pool for 60 s. The mean time spent in all four quadrants and the target area for searching the hidden platform was recorded.4.4. Brain tissue preparationHalf of the animals were decapitated after anesthetization with ethyl carbamate, hippocampus tissues were immediately isolated and stored at −80 °C for further investigations. The second half of each group was used for immunohistochemistry analysis. Animals were perfused intracardially with saline and cold 4% paraformaldehyde. Brains were removed and post-fixed in 4% paraformaldehyde for 24 h.4.5. ImmunohistochemistryFor DAB staining, fixed tissues were embedded in paraffin. Coronal sections (5 μm thick) of the brains were cut on a Leica microtome for immunohistochemistry. Paraffin was removed from the tissue sections with xylene, and the sections were rehydrated in graded ethanol solutions. Endogenous peroxidase activity was blocked with 3% H2O2 for 10 min at room temperature. Antigen retrieval was performed by heating in 10 mmol/L citrate buffer (pH 6.0) for 10 min. After blocked with 5% BSA, sections were incubated with the primary antibody for doublecortin (goat anti-DCX; 1:50), GFAP (rabbit anti-GFAP; 1:100), IBA-1 (goat anti-IBA1; 1:200), 4-Hydroxynonenal antibody (goat anti-4 HNE; 1:200) and anti-8 Hydroxyguanosine antibody (goat anti-8 OHdG; 1:200) at 37 °C for 2 h. For the Anti-8 OHdG histology, enzymatic antigen retrieval with 10 μm/ml proteinase K for 40 min at 37 °C was performed. To detect amyloid deposits, the primary antibody was Aβ1-42 (rabbit anti-Aβ1-42; 1:100), brain sections were pre-incubated with 70% formic acid and incubated at 4 °C for 24 h. They were rinsed in PBS and incubated with biotinylated goat anti-rabbit IgG or biotinylated rabbit anti-goat IgG at 37 °C for 0.5 h and incubated with the avidin-biotin peroxidase complex reagent at 37 °C for 0.5 h. Samples were stained in DAB solution in the presence of H2O2. All stained sections were viewed and photographed under a Zeiss light microscope, and images were captured by Motic Images Plus2.0ML software. The numbers of DCX positive neurons, the areas of Aβ1-42, GFAP, IBA-1, 4-HNE and 8-OHdG positive cells were determined using Image-pro plus6.0 software. The software counts objects that are defined in size and staining threshold by the user. This automated process avoided user bias.4.6. Western blotThe hippocampal tissues from mice was homogenized in ice cold RIPA buffer (containing 1% Triton X-100, 0.1% SDS, 1% deoxycholate) and PMSF (phenyl-methylsulfonyl fluoride). The homogenate was centrifuged 12,000 rpm/min for 5 min at 4 °C before taking the supernatant. Tissue containing 60 μg of protein was separated on 10–12% gradient Bis–Tris gel with molecular marker and electrophoresed in running buffer at 120 mV for 90 min followed by transfer to the PVDF membrane. Following protein transfer, the membrane was washed in TBST (tris buffered saline with 0.05% Tween-20, pH 8) and blocked in 5% skim milk for 1 h. Then incubated overnight at 4 °C with rabbit anti-synaptophysin (SYN) (1:10,000), rabbit anti-Bcl-2 (1:400), rabbit anti-BAX (1:400), rabbit anti-BDNF (1:5000), after three washes in TBS further incubation for 2 h at room temperature with the HRP-labeled goat anti-rabbit immunoglobulin (1:5000). In some cases, the blots were stripped and reprobed with a rabbit anti-β-actin (1:5000) to ensure equal sample loading. The bound antibodies were then visualized by ECL-enhanced chemiluminescence (Beyotime Institute of Biotechnology, Shanghai, China) according to the manufacturer's instructions. Western blot images were captured with a chemiluminescent imaging system (Sage Creation, Beijing, China). All bands were quantified using the image system of Alpha View SA.4.7. Statistical analysisThe data were presented as the mean ± standard error of mean (S.E.M.) and analyzed by one-way or two way ANOVA followed by Bonferroni’s multiple comparison test using the software Prism 5 (Graph Pad Software Inc, La Jolla, CA, USA). Statistical significance is defined as P < 0.05.ContributorsJT, WL and YL conducted the experiments, LL and CH conceived the experiment and wrote the manuscript.AcknowledgementsThis work was funded by the Ministry of Human Resources and Social Security, Shanxi Province [(2010)255], by a Shanxi Scholarship Council of China, and supported by a grant from the Alzheimer Society UK. The authors declare no conflict of interestAppendix A. Supplementary dataReferencesAkiyama et al., 2000H. Akiyama, S. Barger, S. Barnum, B. Bradt, J. Bauer, G.M. Cole, N.R. Cooper, P. Eikelenboom, M. Emmerling, B.L. Fiebich, C.E. Finch, S. Frautschy, W.S. Griffin, H. Hampel, M. Hull, G. Landreth, L. Lue, R. Mrak, I.R. Mackenzie, P.L. McGeer, M.K. O'Banion, J. Pachter, G. Pasinetti, C. Plata-Salaman, J. Rogers, R. Rydel, Y. Shen, W. Streit, R. Strohmeyer, I. Tooyoma, F.L. Van Muiswinkel, R. Veerhuis, D. Walker, S. Webster, B. Wegrzyniak, G. Wenk, T. Wyss-CorayInflammation and Alzheimer’s diseaseNeurobiol. Aging, 21 (2000), pp. 383-421Allen et al., 2013S.J. Allen, J.J. Watson, D.K. Shoemark, N.U. Barua, N.K. PatelGDNF, NGF and BDNF as therapeutic options for neurodegenerationPharmacol. Ther., 138 (2013), pp. 155-175Athauda et al., 2017D. Athauda, K. Maclagan, S.S. Skene, M. Bajwa-Joseph, D. Letchford, K. Chowdhury, S. Hibbert, N. Budnik, L. Zampedri, J. Dickson, Y. Li, I. Aviles-Olmos, T.T. Warner, P. Limousin, A.J. Lees, N.H. Greig, S. Tebbs, T. FoltynieExenatide once weekly versus placebo in Parkinson’s disease: a randomised, double-blind, placebo-controlled trialAviles-Olmos et al., 2013I. Aviles-Olmos, J. Dickson, Z. Kefalopoulou, A. Djamshidian, P. Ell, T. Soderlund, P. Whitton, R. Wyse, T. Isaacs, A. Lees, P. Limousin, T. FoltynieExenatide and the treatment of patients with Parkinson’s diseaseJ. Clin. Invest., 123 (2013), pp. 2730-2736Aviles-Olmos et al., 2014I. Aviles-Olmos, J. Dickson, Z. Kefalopoulou, A. Djamshidian, J. Kahan, P.E. Fmedsci, P. Whitton, R. Wyse, T. Isaacs, A. Lees, P. Limousin, T. FoltynieMotor and cognitive advantages persist 12 months after exenatide exposure in Parkinson’s diseaseJ. Parkinson’s Dis., 4 (2014), pp. 337-344Ayush et al., 2015E.A. Ayush, Y. Iwasaki, S. Iwamoto, H. Nakabayashi, M. Kakei, T. YadaGlucagon directly interacts with vagal afferent nodose ganglion neurons to induce Ca(2+) signaling via glucagon receptorsBiochem. Biophys. Res. Commun., 456 (2015), pp. 727-732Benedetti et al., 2014E. Benedetti, B. D'Angelo, L. Cristiano, E. Di Giacomo, F. Fanelli, S. Moreno, F. Cecconi, A. Fidoamore, A. Antonosante, R. Falcone, R. Ippoliti, A. Giordano, A. CiminiInvolvement of peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) in BDNF signaling during aging and in Alzheimer disease: possible role of 4-hydroxynonenal (4-HNE)Cell Cycle, 13 (2014), pp. 1335-1344Blurton-Jones et al., 2009M. Blurton-Jones, M. Kitazawa, H. Martinez-Coria, N.A. Castello, F.J. Muller, J.F. Loring, T.R. Yamasaki, W.W. Poon, K.N. Green, F.M. LaferlaNeural stem cells improve cognition via BDNF in a transgenic model of Alzheimer diseaseProc. Natl. Acad. Sci. U.S.A., 106 (2009), pp. 13594-13599Campbell and Drucker, 2013J.E. Campbell, D.J. DruckerPharmacology, physiology, and mechanisms of incretin hormone actionCell Metab., 17 (2013), pp. 819-837Cao et al., 2016L. Cao, D. Li, P. Feng, L. Li, G. Xue, G. Li, C. HölscherA novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brainNeuroreport, 37 (2016), pp. 384-391Clark et al., 2012I. Clark, C. Atwood, R. Bowen, G. Paz-Filho, B. VisselTumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationalesPharmacol. Rev., 64 (2012), pp. 1004-1026Doyle and Egan, 2007M.E. Doyle, J.M. EganMechanisms of action of glucagon-like peptide 1 in the pancreasPharmacol. Ther., 113 (2007), pp. 546-593Duffy and Holscher, 2013A.M. Duffy, C. HolscherThe incretin analogue D-Ala(2)GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer’s diseaseNeuroscience, 228 (2013), pp. 294-300Faivre and Holscher, 2013aE. Faivre, C. HolscherD-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer's disease mouse modelJ. Alzheimers Dis., 35 (2013), pp. 267-283Faivre and Holscher, 2013bE. Faivre, C. HolscherNeuroprotective effects of D-Ala2GIP on Alzheimer’s disease biomarkers in an APP/PS1 mouse modelAlzheimers Res. Ther., 5 (2013), pp. 20-28Finan et al., 2013B. Finan, T. Ma, N. Ottaway, T.D. Muller, K.M. Habegger, K.M. Heppner, H. Kirchner, J. Holland, J. Hembree, C. Raver, S.H. Lockie, D.L. Smiley, V. Gelfanov, B. Yang, S. Hofmann, D. Bruemmer, D.J. Drucker, P.T. Pfluger, D. Perez-Tilve, J. Gidda, L. Vignati, L. Zhang, J.B. Hauptman, M. Lau, M. Brecheisen, S. Uhles, W. Riboulet, E. Hainaut, E. Sebokova, K. Conde-Knape, A. Konkar, R.D. DiMarchi, M.H. TschopUnimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humansSci. Transl. Med., 5 (2013), p. 209ra151Finan et al., 2015B. Finan, B. Yang, N. Ottaway, D.L. Smiley, T. Ma, C. Clemmensen, J. Chabenne, L. Zhang, K.M. Habegger, K. Fischer, J.E. Campbell, D. Sandoval, R.J. Seeley, K. Bleicher, S. Uhles, W. Riboulet, J. Funk, C. Hertel, S. Belli, E. Sebokova, K. Conde-Knape, A. Konkar, D.J. Drucker, V. Gelfanov, P.T. Pfluger, T.D. Muller, D. Perez-Tilve, R.D. DiMarchi, M.H. TschopA rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodentsNat. Med., 21 (2015), pp. 27-36Gault and Holscher, 2008aV.A. Gault, C. HolscherGLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloidEur. J. Pharmacol., 587 (2008), pp. 112-117Gault and Holscher, 2008bV.A. Gault, C. HolscherProtease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloidJ. Neurophysiol., 99 (2008), pp. 1590-1595Gejl et al., 2016M. Gejl, A. Gjedde, L. Egefjord, A. Møller, S.B. Hansen, K. Vang, A.B. Rodell, H. Braendgaard, H. Gottrup, A. Schacht, N. Møller, B. Brock, J. RungbyIn Alzheimer’s disease, six-month treatment with glp-1 analogue prevents decline of brain glucose metabolism: randomized, placebo-controlled double-blind clinical trialFront. Aging Neurosci., 8 (2016), pp. 1-10Goto et al., 2008Y. Goto, T. Niidome, H. Hongo, A. Akaike, T. Kihara, H. SugimotoImpaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's diseaseEur. J. Pharmacol., 583 (2008), pp. 84-91Hamilton et al., 2011A. Hamilton, S. Patterson, D. Porter, V.A. Gault, C. HolscherNovel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brainJ. Neurosci. Res., 89 (2011), pp. 481-489Hamilton and Holscher, 2012A. Hamilton, C. HolscherThe effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's diseaseBrain Res., 1449 (2012), pp. 83-93Holscher, 2014C. HolscherInsulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseasesBiochem. Soc. Trans., 42 (2014), pp. 593-599Hölscher, 2016C. HölscherGLP-1 and GIP analogues as novel treatments for Alzheimer’s and Parkinson’s diseaseCardiovasc. Endocrinol., 5 (2016), pp. 93-98Holst et al., 2011J.J. Holst, R. Burcelin, E. NathansonNeuroprotective properties of GLP-1: theoretical and practical applicationsCurr. Med. Res. Opin., 27 (2011), pp. 547-558Hoosein and Gurd, 1984N.M. Hoosein, R.S. GurdIdentification of glucagon receptors in rat brainProc. Natl. Acad. Sci. U.S.A., 81 (1984), pp. 4368-4372Jalewa et al., 2016J. Jalewa, M.K. Sharma, C. HolscherNovel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cellsJ. Neurochem., 139 (2016), pp. 55-67Jalewa et al., 2017J. Jalewa, M. Sharma, S. Gengler, C. HölscherA novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson’s diseaseNeuropharmacology, 117 (2017), pp. 238-248Ji et al., 2001C. Ji, V. Amarnath, J.A. Pietenpol, L.J. Marnett4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c releaseChem. Res. Toxicol., 14 (2001), pp. 1090-1096Ji et al., 2016aC. Ji, G.F. Xue, G. Li, D. Li, C. HolscherNeuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's diseaseRev. Neurosci., 27 (2016), pp. 61-70Ji et al., 2016bC. Ji, G.F. Xue, C. Lijun, P. Feng, D. Li, L. Li, G. Li, C. HolscherA novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDFBrain Res., 1634 (2016), pp. 1-11Kavitha et al., 2013M. Kavitha, J. Nataraj, M.M. Essa, M.A. Memon, T. ManivasagamMangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson's disease miceChem. Biol. Interact., 206 (2013), pp. 239-247Kim et al., 2005S.J. Kim, K. Winter, C. Nian, M. Tsuneoka, Y. Koda, C.H. McIntoshGlucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expressionJ. Biol. Chem., 280 (2005), pp. 22297-22307Kuipers and Bramham, 2006S.D. Kuipers, C.R. BramhamBrain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapyCurr. Opin. Drug Discov. Dev., 9 (2006), pp. 580-586Lee et al., 2010Y.J. Lee, S.B. Han, S.Y. Nam, K.W. Oh, J.T. HongInflammation and Alzheimer's diseaseArch. Pharm. Res., 33 (2010), pp. 1539-1556Li et al., 2010Y. Li, K. Duffy, M. Ottinger, B. Ray, J. Bailey, H. Holloway, D. Tweedie, T. Perry, M. Mattson, D. Kapogiannis, K. Sambamurti, D. Lahiri, N. GreigGLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's diseaseJ. Alzheimers Dis., 19 (2010), pp. 1205-1219Luchsinger et al., 2004J.A. Luchsinger, M.X. Tang, S. Shea, R. MayeuxHyperinsulinemia and risk of Alzheimer diseaseNeurology, 63 (2004), pp. 1187-1192Mayo et al., 2003K.E. Mayo, L.J. Miller, D. Bataille, S. Dalle, B. Goke, B. Thorens, D.J. DruckerInternational Union of Pharmacology. XXXV. The glucagon receptor familyPharmacol. Rev., 55 (2003), pp. 167-194McClean et al., 2011P. McClean, V. Parthsarathy, E. Faivre, C. HölscherThe diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's diseaseJ. Neurosci., 31 (2011), pp. 6587-6594McClean and Holscher, 2014P.L. McClean, C. HolscherLixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's diseaseNeuropharmacology, 86C (2014), pp. 241-258Moloney et al., 2010A.M. Moloney, R.J. Griffin, S. Timmons, R. O'Connor, R. Ravid, C. O'NeillDefects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signallingNeurobiol. Aging, 31 (2010), pp. 224-243Nagahara et al., 2013A.H. Nagahara, M. Mateling, I. Kovacs, L. Wang, S. Eggert, E. Rockenstein, E.H. Koo, E. Masliah, M.H. TuszynskiEarly BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic miceJ. Neurosci., 33 (2013), pp. 15596-15602Ohara et al., 2011T. Ohara, Y. Doi, T. Ninomiya, Y. Hirakawa, J. Hata, T. Iwaki, S. Kanba, Y. KiyoharaGlucose tolerance status and risk of dementia in the community: the Hisayama studyNeurology, 77 (2011), pp. 1126-1134Parthsarathy and Holscher, 2013V. Parthsarathy, C. HolscherThe type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brainEur. J. Pharmacol., 700 (2013), pp. 42-50Perry and Greig, 2004T.A. Perry, N.H. GreigA new Alzheimer's disease interventive strategy: GLP-1Curr. Drug Targets, 5 (2004), pp. 565-571Sharma et al., 2013M. Sharma, J. Jalewa, C. HolscherNeuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to Methylglyoxal stressJ. Neurochem., 128 (2013), pp. 459-471Spielman et al., 2017L.J. Spielman, D.L. Gibson, A. KlegerisIncretin hormones regulate microglia oxidative stress, survival and expression of trophic factorsEur. J. Cell Biol., 96 (2017), pp. 240-253Talbot et al., 2012K. Talbot, H.Y. Wang, H. Kazi, L.Y. Han, K.P. Bakshi, A. Stucky, R.L. Fuino, K.R. Kawaguchi, A.J. Samoyedny, R.S. Wilson, Z. Arvanitakis, J.A. Schneider, B.A. Wolf, D.A. Bennett, J.Q. Trojanowski, S.E. ArnoldDemonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive declineJ. Clin. Invest., 122 (2012), pp. 1316-1338Yuan et al., 2017Z. Yuan, L. Li, P. Feng, G. Xue, C. Ji, G. Li, C. HölscherA novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson’s disease© 2017 Elsevier B.V. All rights reserved."],["topImageUrl","https://ars.els-cdn.com/content/image/1-s2.0-S0006899317X0022X-cov150h.gif"],["error",null]]}]}],["text","阿茲海默症(Alzheimer’s disease)疾病對於病人及家屬皆會帶來很大的影響，然而至目前為止，疾病的發生機轉及可能的治療方式卻仍在研究階段。《Cell Reports》日前刊登中國山西醫科大學(Shanxi Medical University)的最新發表，研究團隊表示，原先發展用來治療糖尿病的特定藥物，有機會反轉阿茲海默症的記憶喪失症狀。第二型糖尿病已知為阿茲海默症的風險因子之一，其病程會影響到胰島素的分泌，而在過去的研究中亦曾發現，這個影響人體血糖調節的荷爾蒙，其分泌不足可能與大腦的退化情形有關。本篇研究中，作者發現結合第二型糖尿病的特定藥物，可能改善數項阿茲海默症的獨特病徵。作者表示，這項研究發現，有助於未來發展阿茲海默症及其它神經退化疾病的新治療方法。\n \n新聞出處：Alzheimer's treatment: Diabetes drug holds promise for fighting disease after 'significantly reversing' memory loss《Independent》\nhttp://www.independent.co.uk/news/health/alzheimers-diabetes-drug-memory-loss-reverse-disease-treatment-degenerative-a8133681.html\n研究刊登在《Cell Reports》第1678卷第64-74頁\nhttps://www.sciencedirect.com/science/article/pii/S0006899317304596\n "],["id","AWEET-BFyCdS-nWhunGr"],["createdAt","2018-01-17T13:29:59.107Z"]]}],["reply",{"__iterable":"Map","data":[["id","AWEElGNbyCdS-nWhunHT"],["user",{"__iterable":"Map","data":[["id","AVriAlOoyrDaTqlmmqhC"],["name","Lin"],["avatarUrl",null],["level",22]]}],["type","RUMOR"],["text","美國布朗大學沃倫阿爾伯特醫學院（The Warren Alpert Medical School of Brown University）的蘇珊教授（Suzanne de la Monte），後續發現阿茲海默症患者不一定有第一型或第二型糖尿病，但腦部也會出現血糖代謝異常的狀況，因此認為阿茲海默症和糖尿病有高度相似性，因此學者提出阿茲海默症為第三型糖尿病的說法。"],["reference","http://www.cofit.me/229093913535506/4688052\n飲食與生活習慣的改善，才是預防阿茲海默症的根本"],["hyperlinks",{"__iterable":"List","data":[{"__iterable":"Map","data":[["title","This area is password protected [401]"],["url","http://www.cofit.me/229093913535506/4688052"],["summary","This area is password protected"],["topImageUrl",""],["error",null]]}]}],["createdAt","2018-01-17T14:44:49.119Z"]]}]]}]}],["searchArticles",{"__iterable":"List","data":[]}],["searchReplies",{"__iterable":"List","data":[]}]]}]]},"replyDetail":{"__iterable":"Map","data":[["state",{"__iterable":"Map","data":[["isLoading",false],["isAuthLoading",false],["isReplyLoading",false]]}],["data",{"__iterable":"Map","data":[["reply",null],["originalReplyConnection",null]]}]]},"auth":{"__iterable":"Map","data":[["state",{"__iterable":"Map","data":[["isLoading",false],["isDialogShown",false]]}],["user",null]]}}

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