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  • 轉分享: 這是中研院生醫所所長郭沛恩院士 (他也是UCSF 教授)寫給前副總統陳健仁及時中部長,関於目前COVID-19 的一些建議,希望政府能夠接納。 Dear VP Chen, Hope that things are going well. I just completed my 9th quarantine after my 9th trip to Taipei during the pandemic and see that the Omicron variant of COVID-19 is now firmly established in Taiwan. While the CECC is moving quickly to address the widening spread of COVID-Omicron and is heading in the right direction, I find that the current policy is unsustainable and the messaging can be much improved. Since I was told that the CECC would welcome my suggestions, I have decided to do so. Please forward this message to the CECC for their consideration. 1. It is now very clear that COVID-Omicron is a very different disease than COVID-ALPHA/BETA/DELTA. Current vaccines are developed from COVID-ALPHA and cannot prevent INFECTION by COVID-Omicron even though they lower significantly the risk of SEVERE DISEASE and DEATH for those who are fully vaccinated and received booster shots recently. In addition, COVID-Omicron is highly contagious and has a very short incubation time; but it causes a milder disease, including shortened disease course and contagious period. 2. Because of the above, contact tracing does not work and avoiding infection is futile except one is in strict isolation or wears a PROPERLY FITTED N95 mask around others (see a very nice article about this in the NYT attached). This means that COVID testing in asymptomatic people is a waste of resources and is justified only in a limited set of situations (such as someone who works closely with vulnerable populations - e.g., nursing home and hospital workers - who has been in close contact with a positive case and needs to test negative to return to work). 3. Although the rate of hospitalization and death due to COVID-Omicron is low, when large populations are infected, the number of severe cases and severe disease is still significant (0.4% of 23 million people hospitalized = 92,000 in the hospital; 0.04% of 23 million people can die = 9,200 deaths) so the key is to keep the vulnerable people from developing severe disease. Medications used for COVID-ALPHA/BETA/DELTA variants such as antibody treatments and Remdesivir, etc., do not work for COVID-Omicron but the oral antivirals from Pfizer and Merck work amazingly well for preventing death (>85% reduction) and hospitalization. Paxlovid has done better in clinical trials to prevent hospitalization but it has many drug-drug interactions so many elderly people cannot use it. Molnupiravir has the theoretical risk of mutagenesis in pregnant women but for the elderly who are past reproductive age, it is a very safe and effective drug to use. I encourage the CECC to contact their counterparts in Japan, Singapore, Israel and the UK to get their experience in using these two oral anti-virals in the recent COVID-Omicron surge. [Full Disclosure: Dr. Dean Li, President of Merck Research Laboratories, is my brother-in-law so I am not pushing the Merck pill for obvious conflict of interest reasons.] Based on the above, my suggestions on messaging are: 1. Tell the country that COVID-Omicron is an entirely different disease than the previous COVID variants so the whole country IS NOT IMMUNE to getting the infection. However, through the sacrifice and cooperation of everyone in Taiwan, the country succeeded in preventing disease and death during the previous waves of infection that caused a lot of problems around the world. This is shared success that the CECC and everyone in Taiwan should take credit, be proud of, and very relieved by. 2. Despite the fact that no one is protected from infection, but because COVID-Omicron is mild, public health policy needs to be adjusted to focus on treating the vulnerable rather than preventing infection of all. 3. Acknowledge that some segments of society have been severely affected by COVID policies so the recovery of these sectors is taken in consideration in updating the public health policy. 4. Acknowledge that some COVID policies were confusing to the public in the past so the new policies will be more consistent and logical. For example, the policy of requiring masking outdoors while people eating at restaurants indoors are not required to mask makes no sense. My suggestions for the new policy are geared towards lowering hospitalization and death rates while avoiding unnecessary disruptions in people's lives: 1. Push vaccination for vulnerable groups (the elderly and those with pre-existing conditions that make them more prone to severe disease). Send vaccination nurses to the nursing homes and neighborhoods with elderly people to get everyone fully vaccinated (including booster shots). Getting the 30% of those 65-75 and 44% of elderly >75 who have not been fully vaccinated and boosted should be a high priority 2. Use the "test positive and treat" strategy for those in vulnerable groups. As I mentioned before, Paxlovid for all but Molnupiravir for those who cannot take Paxlovid. Treat them before their symptoms get worse because it is cheaper to give them the medicine than risk their need for hospitalization. 3. No more putting those with mild disease in special facilities or hospitals so that there are plenty of capacity for those who need hospitalization. 4. Recommend (not mandate with threat of punishment) those who have close contact with COVID-Omicron patients to mask around others for 5 days (no need to do so with household members because they are already given it to them) if they are asymptomatic. 5. No testing of asymptomatic people unless their job requires it (nursing home, hospital, etc.). 6. No more closing schools, factories, or offices because of positive COVID-Omicron cases. 7. No more mandatory masking except for those described in #4 above. People here are so used to masking that many will still do so with the threat of punishment. 8. No more mandatory quarantine, even for those who test positive. Highly recommend those who test positive to wear a mask when around people and not eat with others but not make it a punishable offense. [Treat them like people who have a bad flu, not like criminals.] 9. No more testing or quarantine requirements for visitors from abroad. As the local infection rate is now higher than that many other countries, there is no reason to require new arrivals to do anything different when they are asymptomatic. It's confusing to many that I can go anywhere in the world without quarantine but have to do quarantine plus multiple tests when arriving in Taiwan (and a handful of Asian countries). The benefit of the policies listed above is that the resources of the country are directed toward saving lives rather than collecting lots of infection data. It will reclaim the international travel hub status of Taoyuan International Airport (and not let Singapore and Seoul dominate the air travel sector) and revive the tourism, convention, airline, hotel businesses. It will simplify everyone's life and reduce anxiety. It may be counter intuitive but if you look at the data from the US university campuses and European countries, it is better to get as many young people infected as quickly as possible to shorten the surge while building up herd immunity for COVID-Omicron without a lot of severe cases. The old policy for flattening the curve is to prevent overwhelming the hospitals but with oral antivirals and milder disease, there is no need to flatten the curve. It is better to get the whole surge completed in 2 months like in most countries that pursue a more open policy. I am convinced that when the messaging is clear and based on current understanding of the situation, the people will embrace it and praise the CECC's leadership. Best, Pui -- Pui-Yan Kwok, MD, PhD Director, Institute of Biomedical Sciences Academia Sinica
    11 人回報1 則回應4 年前
  • Welcome to the Reuters.com BETA. Read our Editor's note on how we're helping professionals make smart decisions. June 30, 202110:11 AM CSTLast Updated 2 months ago Healthcare & Pharmaceuticals U.S. Commerce chief says Taiwan's TSMC asked for help getting COVID vaccines Reuters 3 minute read U.S. Secretary of Commerce Gina Raimondo takes a question during a press briefing at the White House in Washington, U.S., April 7, 2021. REUTERS/Kevin Lamarque/File Photo The logo of Taiwan Semiconductor Manufacturing Co (TSMC) is pictured at its headquarters, in Hsinchu, Taiwan, Jan. 19, 2021. REUTERS/Ann Wang/File Photo U.S. Secretary of Commerce Gina Raimondo takes a question during a press briefing at the White House in Washington, U.S., April 7, 2021. REUTERS/Kevin Lamarque/File Photo 1/2 The logo of Taiwan Semiconductor Manufacturing Co (TSMC) is pictured at its headquarters, in Hsinchu, Taiwan, Jan. 19, 2021. REUTERS/Ann Wang/File Photo WASHINGTON, June 29 (Reuters) - U.S. Commerce Secretary Gina Raimondo on Monday said she had spoken with the chief executive of Taiwan Semiconductor Manufacturing Co Ltd (2330.TW) (TSMC) and that he had asked for help getting access to COVID-19 vaccines. Raimondo told Reuters in an interview "he asked for help in that regard, he has spoken to high level officials in the White House. We have responded and we definitely want to be a good partner and I do think it's helping." Taiwan said two weeks ago it will allow officials from Taiwan's Foxconn and TSMC to negotiate on its behalf for COVID-19 vaccines. read more Mid-June the United States shipped 2.5 million COVID-19 vaccine doses to Taiwan, more than tripling Washington's previous allocation of shots for the island. read more TSMC said in a statement to Reuters that they believed "getting vaccines for Taiwan would help to protect the communities and ensure normal operations." Taiwan has been trying to speed up the arrival of the millions of vaccines it has on order as it deals with a rise in domestic cases, although infections remain comparatively low. The request from TSMC, the world's biggest manufacturer of semiconductors on contract, coincides with a global chip shortage that has slowed production of manufacturers around the world, including in the U.S. auto industry where it is forecast the crisis will hit the production of 3.9 million vehicles. Raimondo has a key role in resolving the crisis for U.S. companies. Although there has been no major impact so far on chip production in Taiwan since domestic cases began rising in the middle of May, some U.S. auto executives have told Reuters privately earlier this month they were concerned COVID-19 in Taiwan could impact the flow of semiconductors to U.S. factories. Reporting by David Shepardson in Washington; Additional reporting by Ben Blanchard in Taipei; Editing by Simon Cameron-Moore Our Standards: The Thomson Reuters Trust Principles. More from Reuters Credit Suisse to U.S. staff: get shot, or go home Credit Suisse to U.S. staff: get shot, or go home Credit Suisse to U.S. staff: get shot, or go home German business morale dips on new health worries German business morale dips on new health worries Xiaomi sees revenue surge, eyes EV-market debut Xiaomi sees revenue surge, eyes EV-market debut Toshiba reviewing new strategic ideas - sources Toshiba reviewing new strategic ideas - sources J&J says booster shot vastly increases antibdody J&J says booster shot vastly increases antibdody Qantas aims for international travel in December Qantas aims for international travel in December Air NZ suspends outlook as borders stay shut Air NZ suspends outlook as borders stay shut Japan suspends 1.6 mln doses of Moderna shot Japan suspends 1.6 mln doses of Moderna shot Shakes off menu at UK McDonald's as milk runs dry Shakes off menu at UK McDonald's as milk runs dry Legal Lookahead: Purdue Pharma makes final push to exit bankruptcy Legal Lookahead: Purdue Pharma makes final push to... Read Next United States Illinois Governor to order statewide mask mandate and order masks and vaccines for schools - media 7:55 PM CST Europe EU says COVID boosters may have higher legal risks without EMA approval 7:34 PM CST World Qatar offering COVID vaccines to Afghanistan evacuees yet to transit 7:29 PM CST Americas Brazil's Eurofarma to make Pfizer COVID-19 shots in Latin America 7:10 PM CST Sign up for our newsletter Subscribe for our daily curated newsletter to receive the latest exclusive Reuters coverage delivered to your inbox. Healthcare & Pharmaceuticals Healthcare & Pharmaceuticals · 8:04 PM CST Illinois governor to announce mask mandate, order vaccines for schools - reports Illinois Governor J.B. Pritzker is expected to announce a new COVID-19 policy for the state on Thursday, requiring eligible students and school staffers to be vaccinated and to wear masks in schools and colleges, the Chicago Tribune and other media reported. Healthcare & Pharmaceuticals EU says COVID boosters may have higher legal risks without EMA approval 7:34 PM CST Healthcare & Pharmaceuticals Japan suspends 1.6 mln doses of Moderna shot after contamination reports 8:05 PM CST Healthcare & Pharmaceuticals Sydney hospitals erect emergency tents as COVID-19 cases hit record 12:32 PM CST Healthcare & Pharmaceuticals New Zealand's Ardern says lockdown working to limit Delta spread 3:10 PM CST Latest Home Media Videos Pictures Graphics Browse World Business Legal Markets Breakingviews Technology Investigations Lifestyle About Reuters About Reuters Careers Reuters News Agency Brand Attribution Guidelines Reuters Leadership Reuters Fact Check Reuters Diversity Report Stay Informed Download the App Newsletters Information you can trust Reuters, the news and media division of Thomson Reuters, is the world’s largest multimedia news provider, reaching billions of people worldwide every day. Reuters provides business, financial, national and international news to professionals via desktop terminals, the world's media organizations, industry events and directly to consumers. Follow Us Thomson Reuters Products Westlaw Build the strongest argument relying on authoritative content, attorney-editor expertise, and industry defining technology. Onesource The most comprehensive solution to manage all your complex and ever-expanding tax and compliance needs. Checkpoint The industry leader for online information for tax, accounting and finance professionals. Refinitiv Products Eikon Information, analytics and exclusive news on financial markets - delivered in an intuitive desktop and mobile interface. Refinitiv Data Platform Access to real-time, reference, and non-real time data in the cloud to power your enterprise. World-Check Screen for heightened risk individual and entities globally to help uncover hidden risks in business relationships and human networks. 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    4 人回報1 則回應5 年前
  • 以色列卫生部|辉瑞疫苗杀死的老年人比疾病本身杀死的老年人多40倍 2021年3月5日 摘要 以色列卫生部的最新分析得出结论,在最近5周的疫苗接种期间,辉瑞公司的新冠病毒疫苗导致的死亡人数”大约是该病毒本身导致死亡人数的40倍”,而年轻人的死亡人数则是病毒导致死亡人数的260倍。 以色列卫生部|辉瑞疫苗杀死的老年人比疾病本身杀死的老年人多40倍 New analysis from the Israeli Health Ministry concluded Pfizer's COVID vaccine killed"about 40 times more(elderly)people than the disease itself would have killed"during a recent five-week vaccination period,and 260 times more younger people than would have died from the virus. 以色列卫生部的最新分析得出结论,在最近5周的疫苗接种期间,辉瑞公司的新冠病毒疫苗导致的死亡人数"大约是该病毒本身导致死亡人数的40倍",而年轻人的死亡人数则是病毒导致死亡人数的260倍。 While in January a group of independent doctors concluded that experimental COVID-19 vaccines are"not safer"than the virus itself,a new analysis of vaccine-related death rates in Israel demonstrates that this may indeed be the case to dramatic levels. 今年1月,一组独立医生得出结论,实验性的2019冠状病毒疾病疫苗并不比病毒本身更安全,但对以色列与疫苗相关的死亡率进行的一项新分析表明,情况可能确实如此,达到了惊人的水平。 A re-analysis of published data from the Israeli Health Ministry by Dr.Hervé Seligmann,a member of the faculty of Medicine Emerging Infectious and Tropical Diseases at Aix-Marseille University,and engineer Haim Yativ reveal,in short,that the mRNA experimental vaccine from Pfizer killed"about 40 times more(elderly)people than the disease itself would have killed"during a recent five-week vaccination period.Among the younger class,these numbers are compounded to death rates at 260 times what the COVID-19 virus would have claimed in the given time frame. 艾克斯-马赛大学医学新兴传染病和热带疾病学院的 hervé Seligmann 博士和工程师 Haim Yativ 对以色列卫生部公布的数据进行了重新分析,简而言之,辉瑞公司的 mRNA 实验疫苗在最近五周的疫苗接种期间造成的死亡人数比疾病本身造成的死亡人数多40倍。在年轻一代中,这些数字加起来的死亡率是2019冠状病毒疾病病毒在给定时间范围内的死亡率的260倍。 While the full mathematical analysis may be found in the article itself,the authors demonstrate how among"those vaccinated and above 65,0.2%…died during the three-week period between doses,hence about 200 among 100,000 vaccinated.This is to be compared to the 4.91 dead among 100,000 dying from COVID-19 without vaccination." 虽然完整的数学分析可以在文章本身中找到,但是作者证明了"那些接种疫苗和超过65,0.2%的人......是如何在三周期间死亡的,因此在100,000接种疫苗的人中大约有200人。"。这个数字可以和没有接种疫苗的100,000名死于2019冠状病毒疾病中的4.91人相提并论 "This scary picture also extends to those below 65,"the researchers continued.During the five-week vaccination process"0.05%,meaning 50 among 100,000,died.This is to be compared to the 0.19 per 100,000 dying from COVID-19(who)are not vaccinated…Hence the death rate of this age group increased by 260(times)during this five-week period of the vaccination process,as compared to their natural COVID-19 death rate." 研究人员继续说:"这种可怕的情况也延伸到了65岁以下的人群。"在为期五周的疫苗接种过程中,"0.05%,即10万人中有50人死亡。因此,在这五周的疫苗接种过程中,这个年龄组的死亡率比他们的自然死亡率增加了260倍,而他们的自然死亡率为每100,000人中有0.19人,没有接种2019冠状病毒疾病......因此,这个年龄组的死亡率比他们的自然2019冠状病毒疾病死亡率增加了260倍 As reported by IsraelNationalNews(INN),Seligmann is of Israeli-Luxembourg nationality,has a biology degree from Hebrew University of Jerusalem,and has written more than 100 scientific publications.INN reports the researchers"have no conflicts or interests other than having children in Israel." 据以色列国家新闻报道,塞利格曼是以色列-卢森堡国籍,拥有希伯来大学的生物学学位,并发表过100多篇科学论文。国家旅游局报告说,研究人员"除了在以色列生孩子之外,没有其他利益冲突。" Yativ and Seligmann stipulate that even these"estimated numbers of deaths from the vaccine are probably much lower than actual numbers as it accounts only for those defined as COVID-19 deaths for that short time period and does not include AVC and cardiac(and other)events resulting from the inflammatory reactions." Yativ 和 Seligmann 规定,即使这些"估计的疫苗死亡人数也可能远远低于实际数字,因为它只包括那些在短时间内被定义为2019冠状病毒疾病死亡的人,而不包括由炎症反应导致的动静脉畸形和心脏(以及其他)事件。" Nor do these numbers"account for long-term complications,"they write. 他们写道,这些数字也不能"解释长期并发症"。 In addition,within several months they expect"mid-and long-term adverse effects of the vaccination as ADE(Antibody-dependent Enhancement)"begins to become manifest in those who have received the experimental Pfizer vaccine. 此外,在几个月内,他们预计"中期和长期的不良反应疫苗接种作为 ADE(抗体依赖性增强作用)"开始成为明显的那些已经接受实验辉瑞疫苗。 As explained by America's Frontline Doctors(AFLDS),ADE"is when anti-COVID antibodies,created by a vaccine,instead of protecting the person,cause a more severe or lethal disease when the person is later exposed to SARS-CoV-2 in the wild.The vaccine amplifies the infection rather than preventing damage." 正如美国前线医生(AFLDS)解释的那样,ADE"是指当人后来在野外暴露于 SARS-CoV-2时,由疫苗产生的抗Covid 抗体,而不是保护人体,导致更严重或致命的疾病。这种疫苗加重了感染,而不是防止了损害。" AFLDS provides an example of a vaccine produced to fight the Dengue fever,which resulted in deaths of 600 children in the Philippines due to ADE,and the filing of criminal charges against the decision-makers in 2019. 菲律宾儿童和青少年司提供了一个为防治登革热而生产疫苗的例子,登革热在菲律宾造成600名儿童死亡,2019年对决策者提出了刑事指控。 For these reasons and more,AFLDS and many other doctors strongly discourage the use of these experimental vaccines for most people while only acknowledging that it may be plausible for those over 70 years of age,yet acknowledging that such injections are"a higher risk than early or prophylactic treatment with established medications"(sources here, here, here, and here). 由于这些原因以及更多的原因,AFLDS 和许多其他医生强烈反对大多数人使用这些实验性疫苗,同时只承认这对70岁以上的人来说可能是合理的,但也承认这种注射"比早期或使用现有药物进行预防性治疗的风险更高"(来源是这里、这里、这里和这里)。 Given these death rates,Yativ and Seligmann also have harsh criticism for the severe pressure being imposed upon the population by Israeli authorities to receive these shots.According to INN,the researchers call these draconian efforts"a new Holocaust." 鉴于这些死亡率,Yativ 和 Seligmann 也受到严厉批评,因为以色列当局对居民施加了接受这些射击的严厉压力。国际犹太人学院称,研究人员将这些严酷的努力称为"新的大屠杀" In the past weeks,Israel's government made headlines when they adopted a"green pass"system,allowing people who have been injected to receive a green code,which then grants them entry into places such as entertainment and leisure facilities. 过去几周,以色列政府采用了"绿色通行证"制度,允许被注射者获得绿色代码,然后允许他们进入娱乐和休闲设施等场所。 As the country reopens after a two-month lockdown,the green pass would be given only to those who had been injected,not to people who tested negative for the virus.The proposed benefits include access to"non-essential"businesses as well as not being required to self-isolate if identified as a close contact of a confirmed case of COVID-19,and not having to self-isolate after a return from what the government calls a"red location." 随着这个国家在两个月的封锁后重新开放,绿色通行证将只发给那些被注射的人,而不是那些病毒检测呈阴性的人。拟议的好处包括可以进入"非必要"的企业,如果被确认为确诊的2019冠状病毒疾病病例的密切接触者,不必自我隔离,也不必在从政府所谓的"红色地点"返回后自我隔离 Despite there being no proof that these experimental vaccines actually prevent transmission of the virus,Israel's minister for health,Yuli Edelstein,said upon the release of the vaccine"passport"that"(g)etting vaccinated is a moral duty.It is part of our mutual responsibility."He went further,declaring,"Whoever does not get vaccinated will be left behind." 尽管没有证据表明这些实验性疫苗实际上能够阻止病毒的传播,但以色列卫生部长 Yuli Edelstein 在疫苗"护照"发放时表示,"(g)接种疫苗是一种道德义务。这是我们共同责任的一部分。"他更进一步,宣称:"不接种疫苗的人将被留下。" The green pass needs renewing every six months,and despite holding one,an individual must still abide by masking and physical distancing rules.The Jerusalem Post also reported that legislation is being considered to grant employers the right to refuse unvaccinated people entry into the workplace. 绿色通行证需要每六个月更新一次,尽管持有绿色通行证,个人仍然必须遵守伪装和物理距离规则。《耶路撒冷邮报》还报告说,正在考虑通过立法给予雇主拒绝未接种疫苗的人进入工作场所的权利。 Such measures prompted Business Insider to describe the country as"waging a war on the unvaccinated."Meanwhile,Dr.Anthony Fauci,chief medical adviser to President Joe Biden,has styled Israel's vaccination response as"extraordinarily good." 这些措施促使商业内幕组织将这个国家描述为"向未接种疫苗的人发动战争"与此同时,总统乔·拜登的首席医疗顾问安东尼·福奇博士将以色列的疫苗接种反应形容为"非常好" 来源: https://www.lifesitenews.com/news/experimental-vaccine-death-rate-for-israels-elderly-40-times-higher-than-covid-19-deaths-researchers
    5 人回報1 則回應5 年前